Biliary-derived hepatocytes in chronic liver injury: Bringing new troops to the battlefield?

Aleksieva, Niya; Forbes, Stuart J.

doi:10.1016/j.jhep.2019.03.015

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Nevertheless, most of the investigations were performed in animal models which have some limitations. Considering the fact that during chronic liver injury a variety of cells can respond to the need for cell replacement and liver regeneration (165)(166)(167), it is highly likely that the cell of origin of HCC is equally context-specific. Therefore, it is crucial to further strengthen the examination of human HCC, to identify the cells that give rise to liver tumors and elucidate the different classes of tumors based on their molecular features.…”

Section: Resultsmentioning

confidence: 99%

Hepatocellular carcinoma

2021

Cancers in the Urban Environment

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Section: Resultsmentioning

confidence: 99%

Hepatocellular carcinoma

2021

Cancers in the Urban Environment

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“…According to that, lineage tracing studies indicated that hepatocytes are able to restore hepatic parenchyma after subcritical liver resection and regenerate cell loss after acute and chronic damage; furthermore, studies on cell plasticity in rodents indicated the potential of hepatocytes to differentiate toward biliary cells after injury ( 1 – 5 ). Therefore, conflicting evidence is present in scientific literature regarding the existence and function of a distinct stem/progenitor cell population capable of participating in liver regeneration ( 6 ). Nonetheless, experimental models characterized by an extensive (or prolonged over time) liver injury, which mimic the natural history of human liver diseases, demonstrated the contribution of stem/progenitor cells in the regenerative response ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

Distinct EpCAM-Positive Stem Cell Niches Are Engaged in Chronic and Neoplastic Liver Diseases

et al. 2020

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In normal human livers, EpCAM pos cells are mostly restricted in two distinct niches, which are (i) the bile ductules and (ii) the mucous glands present inside the wall of large intrahepatic bile ducts (the so-called peribiliary glands). These EpCAM pos cell niches have been proven to harbor stem/progenitor cells with great importance in liver and biliary tree regeneration and in the pathophysiology of human diseases. The EpCAM pos progenitor cells within bile ductules are engaged in driving regenerative processes in chronic diseases affecting hepatocytes or interlobular bile ducts. The EpCAM pos population within peribiliary glands is activated when regenerative needs are finalized to repair large intra- or extra-hepatic bile ducts affected by chronic pathologies, including primary sclerosing cholangitis and ischemia-induced cholangiopathies after orthotopic liver transplantation. Finally, the presence of distinct EpCAM pos cell populations may explain the histological and molecular heterogeneity characterizing cholangiocarcinoma, based on the concept of multiple candidate cells of origin. This review aimed to describe the precise anatomical distribution of EpCAM pos populations within the liver and the biliary tree and to discuss their contribution in the pathophysiology of human liver diseases, as well as their potential role in regenerative medicine of the liver.

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