Biliary colic treatment and acute cholecystitis prevention by prostaglandin inhibitor

Goldman, Gideon; Kahn, Perry J.; Alon, R.; Wiznitzer, T

doi:10.1007/bf01540262

Cited by 52 publications

(22 citation statements)

References 2 publications

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“…Finally, we found that use of NSAIDs was less prevalent in the case group. This feature is consistent with previous findings [44,45] and increase the internal validity of our study, although it was not the main purpose of our study. Several limitations of the present study should be noted.…”

Section: Discussionsupporting

confidence: 93%

Statin use and the risk of gallstone disease: a population-based case–control study

Chiu

Chen

Kuo

et al. 2012

Expert Opinion on Drug Safety

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Section: Discussionsupporting

confidence: 93%

Statin use and the risk of gallstone disease: a population-based case–control study

Chiu

Chen

Kuo

et al. 2012

Expert Opinion on Drug Safety

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“…The prostanoids, cyclooxygenase (COX) metabolites, are involved in gallbladder muscle contraction and mucosal water transport [20,21], and mediate gallbladder inflammatory responses, which are inhibited by nonsteroidal antiinflammatory drugs (NSAIDs) [22,23]. Thus, biliary pain associated with gallstone disease is mediated by prostanoids, and is treated with NSAIDs [24,25].…”

Section: Cholecystitis and Malignant Lesionsmentioning

confidence: 98%

Carcinogenesis of malignant lesions of the gall bladder

Tazuma

Kajiyama

2001

Langenbeck's Arch Surg

110

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Gallbladder carcinoma is an uncommon but highly malignant tumor with a poor 5-year survival rate. The presence of gallstones is a well-established risk factor for gallbladder carcinoma, and the risk seems to correlate with stone size. Metaplastic changes of the gallbladder epithelium present in chronic cholecystitis may be a premalignant lesion. Solitary polyps with a size of greater than 1 cm are recognized as a predisposing factor for gallbladder carcinoma when their characteristics are echopenic, sessile, and high cell density. Endoscopic ultrasound is the most useful technique to detect the early changes of malignancy in polyps. Anomalous junction of pancreaticobiliary ducts (AJPBD) without a choledochal cyst and porcelain gallbladder is an additional risk factor for gallbladder malignancy. At the molecular level, it has been proposed that chronic inflammation of the gallbladder may lead to the loss of p53 gene heterozygosity and excessive expression of p53 protein. Furthermore, a proposed mechanism underlying the high risk of gallbladder carcinoma in patients with AJPBD is that chronic reflux of pancreatic juice causes intestinal metaplasia, hyperplasia, and dysplasia with the mutation of p53 and K-ras. In contrast, the causal relationship between porcelain gallbladder and malignancy is yet to be established. In this article, recognition of risk factors for gallbladder carcinoma was summarized with special attention to gallstones and chronic inflammation.

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“…Parenteral nsNSAIDs such as ketorolac, tenoxicam or diclofenac were at least as effective as parenteral opioids and more effective than buscopan in providing analgesia for biliary colic (Goldman et al, 1989 IM atropine was no more effective than saline in the treatment of acute biliary colic (Rothrock et al, 1993 Level II).…”

Section: Biliary Colic and Acute Pancreatitismentioning

confidence: 99%

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

Cohen

Smit

Andrianopoulos³

et al. 2017

Medical Journal of Australia

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Objectives: This study aimed to assess analgesia provided by acupuncture, alone or in combination with pharmacotherapy, to patients presenting to emergency departments with acute low back pain, migraine or ankle sprain. Design: A pragmatic, multicentre, randomised, assessor‐blinded, equivalence and non‐inferiority trial of analgesia, comparing acupuncture alone, acupuncture plus pharmacotherapy, and pharmacotherapy alone for alleviating pain in the emergency department. Setting, participants: Patients presenting to emergency departments in one of four tertiary hospitals in Melbourne with acute low back pain, migraine, or ankle sprain, and with a pain score on a 10‐point verbal numerical rating scale (VNRS) of at least 4. Main outcome measures: The primary outcome measure was pain at one hour (T1). Clinically relevant pain relief was defined as achieving a VNRS score below 4, and statistically relevant pain relief as a reduction in VNRS score of greater than 2 units. Results: 1964 patients were assessed between January 2010 and December 2011; 528 patients with acute low back pain (270 patients), migraine (92) or ankle sprain (166) were randomised to acupuncture alone (177 patients), acupuncture plus pharmacotherapy (178) or pharmacotherapy alone (173). Equivalence and non‐inferiority of treatment groups was found overall and for the low back pain and ankle sprain groups in both intention‐to‐treat and per protocol (PP) analyses, except in the PP equivalence testing of the ankle sprain group. 15.6% of patients had clinically relevant pain relief and 36.9% had statistically relevant pain relief at T1; there were no between‐group differences. Conclusion: The effectiveness of acupuncture in providing acute analgesia for patients with back pain and ankle sprain was comparable with that of pharmacotherapy. Acupuncture is a safe and acceptable form of analgesia, but none of the examined therapies provided optimal acute analgesia. More effective options are needed. Trial registration: Australian New Zealand Clinical Trials Registry, ACTRN12609000989246.

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Biliary colic treatment and acute cholecystitis prevention by prostaglandin inhibitor

Cited by 52 publications

References 2 publications

Statin use and the risk of gallstone disease: a population-based case–control study

Statin use and the risk of gallstone disease: a population-based case–control study

Carcinogenesis of malignant lesions of the gall bladder

Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non‐inferiority trial

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