Biliary and pancreatic secretions influence experimental duodenal ulcer without affecting gastric secretion in the rat

Abstract

The effect of the absence of biliary and/or pancreatic secretions in the duodenum or the enhanced presence of bile at the proximal duodenum on the incidence, severity, number, and location of cysteamine-induced duodenal ulcers was investigated in the rat. Cysteamine produced ulcers on the anterior wall of the duodenum in 75% and on the posterior wall ("kissing ulcers") in 50% of the animals. Diversion of biliary and/or pancreatic secretions from the duodenum increased both the severity and the incidence of the posterior duodenal ulcers. Diversion of bile to the proximal duodenum, on the other hand, decreased the severity as well as the incidence of the anterior duodenal ulcers. Mortality in rats receiving cysteamine correlated with the severity of ulcers. Taurocholic acid at nontoxic doses given subcutaneously or orally to nonoperated rats and rats which had bile diverted to the proximal duodenum aggravated the cysteamine-caused duodenal ulcers. Neither proximal nor distal diversion of bile had a major effect on gastric secretion of acid and pepsin in normal or cysteamine-treated rats. We conclude that both bile and pancreatic secretions may directly influence the development of cysteamine-induced duodenal ulcers in the rat.

Origin of the Low pH Values along the Proximal Duodenum in Sheep

“…In the dog, the MMC pattern is detected only during the interdigestive period ( 1 6 1 7 hours after feeding), when the duodenal pH averages 7.8 and the contents are represented by a brownish fluid containing mucus, foam, bile, pancreatic and duodenal secretions (4). A similar situation is found i n the rat (9) and man (13) where biliary-pancreatic secretions may influence the incidence of duodenal ulcers. I n sheep, the abomasal acid secretion is continuous because of the permanent delivery of digesta from the forestomach, the composition of the digesta leaving the abomasum is regular (7) and there are n o interdigestive periods.…”

Pharmacotherapy of Peptic Ulcer Disease

“…Motility abn orma lities found in experimental ulcers include decreased waves and mi., xing waves in the prox ima l duodenum a nd inc reased waves in the d istal duodenum ( 27). The ir interaction causes a diversion of biliary and/or panc reatic secretions, with increased inc id en ce a nd severi ty of posterio r wa ll ulce r induced by cysteamine in the ra t. Correction of this d iversion reverses the effect (28).…”