Biliary Adenofibroma: A Rare Liver Tumor with Transition to Invasive Carcinoma

Alshbib, Ayham; Grzyb, Krzysztof; Syversveen, Trygve; Reims, Henrik M.; Lassen, Kristoffer; Yaqub, Sheraz

doi:10.1155/2022/5280884

Cited by 3 publications

(6 citation statements)

References 22 publications

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“…More than half of the patients presented with epigastric pain, and 30% had no clinical symptoms. Three cases had an elevated CA19-9 concentration [3,5,6], and one case had an elevated CA12-5 concentration [7]. The other three cases had hepatitis B [8][9][10], and one case had hepatitis C [11].…”

Section: Discussionmentioning

confidence: 96%

“…The case presented in our hospital was BAF with invasive carcinoma. We analyzed the pathological data and found that two of the 18 cases of malignant BAF had metastases during the follow-up [2,3]. Two of the 16 cases of benign BAF had local recurrence during followup [4].…”

Section: Discussionmentioning

confidence: 99%

“…We performed a detailed analysis of imaging information from previous cases (see Appendix) in which the median size of the lesion was 6.55 and ranged from 0.7 to 20 cm, which was mainly located under the capsule (50%) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Most of the lesions were multilobulated and multiseptated cystic.…”

Section: Discussionmentioning

confidence: 99%

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Imaging Features of Biliary Adenofibroma With Malignant Transformation: A Case Report and Literature Review

Zhang,

Chen,

Shi

et al. 2024

Cureus

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Biliary adenofibroma (BAF) is a rare benign tumor, but it has the potential for malignant transformation. The differentiation between benign and malignant forms of BAF before surgery is of great importance for clinical decision-making. We report a case of BAF with invasive carcinoma. The patient did not present any clinical symptoms but had a history of hepatitis B virus infection for more than twenty years. Magnetic resonance imaging (MRI) revealed a solid and cystic 4 cm mass in segment II of the liver exhibiting hypointense signals on T1-weighted images and intermediate-to-high intensity signals on T2-weighted images. Enhancement scanning revealed markedly rim-like enhancement on the arterial phase, with the left inter-hepatic artery as the tumor-feeding artery, and wash-out on the venous and delayed phases. To the best of our knowledge, BAF with invasive carcinoma is uncommon. Preoperative qualitative diagnosis based on imaging features can achieve the maximum benefit for patients.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Imaging Features of Biliary Adenofibroma With Malignant Transformation: A Case Report and Literature Review

Zhang,

Chen,

Shi

et al. 2024

Cureus

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“…The reported Ki-67 proliferating index is less than 10% in BAF, whereas 20-30% in the invasive component. 4 , 9 , 12 - 15 …”

Section: Discussionmentioning

confidence: 99%

Biliary adenofibroma: a precursor lesion of intrahepatic cholangiocarcinoma

Parkhi,

Joshi,

Kumar

et al. 2023

Autops Case Rep

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Biliary adenofibroma (BAF) is an uncommon liver tumor with a high propensity for malignant transformation. The histomorphology of BAF with malignant transformation can show a spectrum of changes ranging from benign, dysplastic to frank malignancy. Thus, the diagnosis of BAF imposes the pursuit of dysplasia/ malignancy focus. We presented a case of intrahepatic cholangiocarcinoma arising from BAF in a 49-year-old woman with detailed histomorphology. We also performed a PubMed database search and tabulated all previously reported cases of BAF with dysplasia/ malignant transformation. A statistic comparison of age, sex ratio, size of the tumor, and survival following complete resection between BAFs with and without dysplasia/ malignancy from the retrieved data is presented. Our analysis did not highlight any statistically significant difference between BAFs with and without dysplasia/ malignancy in age, sex ratio, tumor size, and survival following complete surgical resection. Our study highlights the histopathology and immunohistochemistry of a case of BAF with malignant transformation and highlights the importance of this diagnosis in management. Further longitudinal studies on a larger cohort of patients are required to validate our findings.

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“…Wide local resection is recommended as the primary treatment for BAFs with malignant transformation, and follow-up imaging is needed for potential recurrence[ 2 ]. Only 2 of the reported patients developed recurrence after surgery, presenting as local hepatic recurrence, and 1 with pulmonary metastasis[ 8 , 9 ], whereas other cases, with follow-up data from 1 mo to 9 years, had no postoperative recurrence. Therefore, despite the heterogeneity of the pathological features in these cases, BAFs with malignant transformation generally have a good prognosis after complete resection.…”

Section: Discussionmentioning

confidence: 99%

Malignant transformation of biliary adenofibroma combined with benign lymphadenopathy mimicking advanced liver carcinoma: A case report

Wang¹,

Chen²,

Cheng³

et al. 2022

WJCC

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BACKGROUND Biliary adenofibromas (BAFs) are rare primary hepatic neoplasms, some of which can potentially undergo malignant transformation. Here, we describe a rare case of malignant transformation of BAF. CASE SUMMARY A 51-year-old female was referred to our hospital with epigastric pain. Computed tomography showed a solitary liver mass combined with the enlargement of multiple mediastinal and cervical lymph nodes, clinically mimicking a liver carcinoma with extensive lymph node metastasis. However, core needle biopsy suggested BAF with malignant transformation. Finally, the patient underwent curative resection of the neoplasm and was recurrence-free for 12 mo. CONCLUSION Our case serves as an example of a rare manifestation of BAF. Our report and the previously published experience, reinforce that curative resection should be considered the primary treatment for BAFs with malignant transformation, leading to a favorable prognosis.

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Biliary Adenofibroma: A Rare Liver Tumor with Transition to Invasive Carcinoma

Cited by 3 publications

References 22 publications

Imaging Features of Biliary Adenofibroma With Malignant Transformation: A Case Report and Literature Review

Imaging Features of Biliary Adenofibroma With Malignant Transformation: A Case Report and Literature Review

Biliary adenofibroma: a precursor lesion of intrahepatic cholangiocarcinoma

Malignant transformation of biliary adenofibroma combined with benign lymphadenopathy mimicking advanced liver carcinoma: A case report

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