Bile salts in digestion and transport of lipids

Macierzanka, Adam; Torcello‐Gómez, Amelia; Jungnickel, Christian; Maldonado-Valderrama, Julia

doi:10.1016/j.cis.2019.102045

Cited by 125 publications

(79 citation statements)

References 161 publications

(199 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, the bile acid pool in mice consists mostly of hydrophilic bile acids, muricholic acids, and cholic acids, and thus differs significantly from the more hydrophobic bile acid pool in humans [6]. Due to these limitations of in vivo studies, only little or no details on the intermediate mechanisms of bile acid interactions can be elucidated from their physiological outcomes [11]. Therefore, in vitro studies mimicking the physiological environment in the small intestine are of major interest in order to elucidate the basic mechanisms and identify hypotheses for targeted in vivo investigation.…”

Section: In Vivo Approaches To Study Bile Acid Interactionsmentioning

confidence: 99%

“…Dietary fibre may occur in isolated form or as part of complex cell-wall architectures. Therefore, the group of dietary fibres comprises a multitude of different structures [11]. Human ileostomy studies have shown that a diet fortified in dietary fibre from oat induces increased bile excretion within 24 h after consumption [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the group of dietary fibres comprises a multitude of different structures [11]. Human ileostomy studies have shown that a diet fortified in dietary fibre from oat induces increased bile excretion within 24 h after consumption [11][12][13]. Most studies thus agree that dietary fibres majorly contribute to bile acid interaction in digests of plant compounds [3,5,11].…”

Section: Introductionmentioning

confidence: 99%

“…Human ileostomy studies have shown that a diet fortified in dietary fibre from oat induces increased bile excretion within 24 h after consumption [11][12][13]. Most studies thus agree that dietary fibres majorly contribute to bile acid interaction in digests of plant compounds [3,5,11]. However, studies on dietary fibre retaining intact cell-wall structures fail to provide conclusive results regarding the nature and mechanism of the interactions with bile acids [11].…”

Section: Introductionmentioning

confidence: 99%

“…Most studies thus agree that dietary fibres majorly contribute to bile acid interaction in digests of plant compounds [3,5,11]. However, studies on dietary fibre retaining intact cell-wall structures fail to provide conclusive results regarding the nature and mechanism of the interactions with bile acids [11]. In particular, high variabilities were reported when comparing results on an equal dietary fibre basis for various fruits [14].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review

Naumann

Haller

Eisner

et al. 2020

IJMS

View full text Add to dashboard Cite

Plant compounds are described to interact with bile acids during small intestinal digestion. This review will summarise mechanisms of interaction between bile acids and plant compounds, challenges in in vivo and in vitro analyses, and possible consequences on health. The main mechanisms of interaction assume that increased viscosity during digestion results in reduced micellar mobility of bile acids, or that bile acids and plant compounds are associated or complexed at the molecular level. Increasing viscosity during digestion due to specific dietary fibres is considered a central reason for bile acid retention. Furthermore, hydrophobic interactions are proposed to contribute to bile acid retention in the small intestine. Although frequently hypothesised, no mechanism of permanent binding of bile acids by dietary fibres or indigestible protein fractions has yet been demonstrated. Otherwise, various polyphenolic structures were recently associated with reduced micellar solubility and modification of steroid and bile acid excretion but underlying molecular mechanisms of interaction are not yet fully understood. Therefore, future research activities need to consider the complex composition and cell-wall structures as influenced by processing when investigating bile acid interactions. Furthermore, influences of bile acid interactions on gut microbiota need to be addressed to clarify their role in bile acid metabolism.

show abstract

Section: In Vivo Approaches To Study Bile Acid Interactionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review

Naumann

Haller

Eisner

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

Structure Formation in Tailor‐Made Buriti Oil Emulsion During Simulated Digestion

Freire

Hong

Peterek

et al. 2023

Adv Funct Materials

View full text Add to dashboard Cite

Functional food emulsions enriched in health‐promoting nutrients can help to maintain and improve health and lifestyle. The oil extracted from the Amazonian buriti fruit is renowned for its high levels of carotenoid, vitamin E, and unsaturated fatty acids, which have been linked to improvements in cardiometabolic health. Here, buriti oil in water emulsions are developed and their colloidal transformations are investigated in an advanced digestion model with oral, gastric, and intestinal parts with in situ synchrotron small‐angle X‐ray scattering, cryogenic electron microscopy, and dynamic light scattering under simulated “healthy” and “compromised” digestive conditions. The interior oil phase of whey‐stabilized buriti oil‐in‐water emulsion transforms into highly ordered lyotropic liquid crystalline structures during simulated intestinal digestion at compromised bile conditions. Simulated gastric digestion influences intestinal digestion by slowing it down, resulting in less ordered structures. The digestion‐triggered structure formation is pH‐ and bile salt‐dependent and can be modulated by adding vitamin E to the oil. This tailoring of structures during digestion offers a new pathway to steer digestion kinetics and nutrient bioavailability.

show abstract

Early Detection and Monitoring of Anastomotic Leaks via Naked Eye‐Readable, Non‐Electronic Macromolecular Network Sensors

Jessernig,

Anthis,

Vonna

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Anastomotic leakage (AL) is the leaking of non‐sterile gastrointestinal contents into a patient's abdominal cavity. AL is one of the most dreaded complications following gastrointestinal surgery, with mortality rates reaching up to 27%. The current diagnostic methods for anastomotic leaks are limited in sensitivity and specificity. Since the timing of detection directly impacts patient outcomes, developing new, fast, and simple methods for early leak detection is crucial. Here, a naked eye‐readable, electronic‐free macromolecular network drain fluid sensor is introduced for continuous monitoring and early detection of AL at the patient's bedside. The sensor array comprises three different macromolecular network sensing elements, each tailored for selectivity toward the three major digestive enzymes found in the drainage fluid during a developing AL. Upon digestion of the macromolecular network structure by the respective digestive enzymes, the sensor produces an optical shift discernible to the naked eye. The diagnostic efficacy and clinical applicability of these sensors are demonstrated using clinical samples from 32 patients, yielding a Receiver Operating Characteristic Area Under the Curve (ROC AUC) of 1.0. This work has the potential to significantly contribute to improved patient outcomes through continuous monitoring and early, low‐cost, and reliable AL detection.

show abstract

Bile salts in digestion and transport of lipids

Cited by 125 publications

References 161 publications

Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review

Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review

Structure Formation in Tailor‐Made Buriti Oil Emulsion During Simulated Digestion

Early Detection and Monitoring of Anastomotic Leaks via Naked Eye‐Readable, Non‐Electronic Macromolecular Network Sensors

Contact Info

Product

Resources

About