“…However, in some models, acute reversible cholestasis occurs after LPS injection. The pathogenesis of this form of cholestasis, which is clinically represented by the cholestasis associated with sepsis, severe infection or acute severe inflammatory disease, is unknown (Quiroga, 1992). It has been attributed, at least in part, to an excessive production of cysteinyl-LTs (Keppler et al, 1988), since the injection of high doses of LTC 4 to the guinea pig induces cholestasis, which also develops after the simultaneous administration of pharmacological doses of both, LTD4 and PGE 2, to the rat (Keppler et al, 1985).…”