The Bile Acids: Chemistry, Physiology, and Metabolism 1976
DOI: 10.1007/978-1-4615-7563-4_3
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Bile-Salt-Protein Interactions

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1983
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Cited by 4 publications
(3 citation statements)
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“…Bile salts, integral for dietary fat digestion and absorption in the small intestine (Chiang & Ferrell, 2018 ), have diverse roles, including the regulation of cellular homeostasis and the modulation of gut bacterial growth (Larabi et al, 2023 ). Moreover, bile salts can alter protein structure and function, and are known to induce a compact conformation of TcdB (Aguirre et al, 2021 ; Cremers et al, 2014 ; Nair, 1976 ; Tam et al, 2020 ; Winston & Theriot, 2016 ; Zhuang et al, 2017 ). However, the impact of bile on the binding and inhibitory capacity of V H Hs towards TcdB remains relatively unexplored.…”
Section: Discussionmentioning
confidence: 99%
“…Bile salts, integral for dietary fat digestion and absorption in the small intestine (Chiang & Ferrell, 2018 ), have diverse roles, including the regulation of cellular homeostasis and the modulation of gut bacterial growth (Larabi et al, 2023 ). Moreover, bile salts can alter protein structure and function, and are known to induce a compact conformation of TcdB (Aguirre et al, 2021 ; Cremers et al, 2014 ; Nair, 1976 ; Tam et al, 2020 ; Winston & Theriot, 2016 ; Zhuang et al, 2017 ). However, the impact of bile on the binding and inhibitory capacity of V H Hs towards TcdB remains relatively unexplored.…”
Section: Discussionmentioning
confidence: 99%
“…The detergent-property of bile salts [9] and the capacity of ionic detergents to split off the enzyme-bound pyridoxal phosphate [37,38] are well known. In order to examine whether sodium cholate had any effect on the coenzyme absorption spectrum of phosphorylase h, the enzyme (10 mg/ml, in 1 mM EDTA, 20 mM glycerol-2-P buffer, pH 6.8) was treated with 5, 10, and 20mM sodium cholate.…”
Section: Effkct Qf' Sodium Cholutr On [He Structure Of' Phosphorylase Bmentioning
confidence: 99%
“…In an effort to investigate the problem of 'hydrophobic activation of phosphorylase h', we have examined the catalytic and structural behaviour of phosphorylase molecule in presence of bile salts. These steroid molecules form a unique group of biological detergents, are amphiphilic in nature possessing distinct lipophilic and hydrophilic centers and they are able to modulate the biological activity of various enzymes through specific ligand-protein interactions [9]. We have found that sodium cholate was able to partially activate phosphorylase h in absence of AMP and that this activation was highly specific.…”
mentioning
confidence: 99%