Bile levels of carcino-embryonic antigen in patients with hepatopancreatobiliary disease

Buffet, Catherine; Fourré, C.; Altman, Claude; Prat, Frédéric; Fritsch, Júlia; Choury, André-Daniel; Briantais, Marie-José; Desgrez, A.; Etienne, Jean-Pierre

doi:10.1097/00042737-199602000-00007

Cited by 13 publications

(11 citation statements)

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“…As mentioned above, several studies have indicated that nonspecific elevations of the bile CEA levels were observed in patients with benign biliary diseases (8)(9)(10)(11)15). This phenomenon may be explained by the fact that human bile contains several CEA related substances such as biliary glycoprotein 1, a nonspecific cross-reacting antigen that can potentially cross-react with CEA (10).…”

Section: Discussionmentioning

confidence: 93%

“…This antigen has been detected in various body fluids such as the gastrointestinal and pancreatobiliary juice (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). Several studies have described the diagnostic utility of the increased CEA levels in the body fluids in primary malignant tumors arising from the stomach, colon, biliary tract, and pancreas (4-11).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have described the diagnostic utility of the increased CEA levels in the body fluids in primary malignant tumors arising from the stomach, colon, biliary tract, and pancreas (4-11). In particular, some attempts have been made to analyze the bile juice for a measurement of the CEA content to predict the presence of bile duct cancer (7)(8)(9)(10)(11). In addition to a primary malignant tumor, the relationships between the bile CEA levels in the gallbladder or bile duct and a colorectal liver metastasis have been also reported (12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, several reports have shown nonspecific elevations of the bile CEA levels in benign biliary diseases patients, e.g. choledocholithiasis (8)(9)(10)(11)15). In contrary to the bile CEA levels, the serum CEA level may be controlled by several factors, including the production of CEA by cancer cells, the release from the tumor directly into the blood stream and its metabolic degradation in the liver (16,17).…”

Section: Discussionmentioning

confidence: 99%

“…Currently, the performance of the available tumor markers as screening tests for diagnosing a malignancy in high risk individuals is inadequate because of the reduced sensitivity and occasional false-positive results (1)(2)(3). However, several studies have suggested that measuring the CEA in the body fluid bathing primary or metastatic tumors may be more useful than the serum value (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). The aim of this study was to determine the diagnostic role of the bile CEA levels in patients with bile duct cancer.…”

Section: Introductionmentioning

confidence: 99%

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The Role of Bile Carcinoembryonic Antigen in Diagnosing Bile Duct Cancer

et al. 2003

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It is known that the fluids bathing tumors might contain a higher level of the carcinoembryonic antigen (CEA) than those found in the blood. Therefore, we evaluated the role of bile CEA in diagnosing bile duct cancer. One hundred and thirty two patients were prospectively studied. The patients were divided into 3 groups: the bile duct cancer (n=32), pancreatic cancer (n=16), and benign biliary diseases (n=84) groups. Bile samples were obtained on the next day of the biliary drainage procedures. The mean bile CEA level in those with bile duct cancer (120.6±156.9 ng/mL) was significantly higher than those with pancreatic cancer and benign biliary diseases (32.0±28.5 ng/mL, 29.3±56.3 ng/mL). Using the level of 20 ng/mL, the sensitivity and specificity of bile CEA in the diagnosis of bile duct cancer from benign biliary diseases were 65.6% and 66.7%, respectively. Both the bile CEA and total bilirubin level were found to be an independent factor linked to bile duct cancer. This study result suggests that bile CEA level is a useful supplementary test for diagnosing bile duct cancer.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Role of Bile Carcinoembryonic Antigen in Diagnosing Bile Duct Cancer

et al. 2003

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Bile Proteome in Health and Disease

Farina¹,

Delhaye²,

Lescuyer³

et al. 2014

Comprehensive Physiology

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The study of bile proteins could improve the understanding of physiological processes involved in the regulation of the hepato-biliary system. Researchers have tried for years to investigate the bile proteome but, until recently, only a few tens of proteins were known. The advent of proteomics, availing of large-scale analytical devices paired with potent bioinformatic resources, lately allowed the identification of thousands of proteins in bile. Nevertheless, the knowledge of their role in the hepato-biliary system still represents almost a "blank page in the book of physiology." In this review, we first guide the reader through the historical phases of the analysis of bile protein content, emphasizing the recent progresses achieved through the use of proteomic techniques. Thereafter, we deeply explore the involvement of bile proteins in health and disease, with a particular focus on the discovery of biomarkers for biliary tract malignancies.

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