Bile diversion in rats leads to a decreased plasma concentration of linoleic acid which is not due to decreased net intestinal absorption of dietary linoleic acid

Minich, DM; Kalivianakis, M; Havinga, Rick; Goor, van Harry; Stellaard, Frans; Vonk, Roelf; Kuipers, Folkert; Verkade, Henkjan J.

doi:10.1016/s1388-1981(99)00033-5

Cited by 26 publications

(14 citation statements)

References 21 publications

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“…A theoretical alternative for the use of plasma values would have been the quantitation of the unabsorbed 13 C-fatty acids in the feces. However, the correlation between unabsorbed (fecal) concentrations of 13 C-fatty acids and dietary fat absorption has been demonstrated to be weak, probably attributable to tracer effects and to compensatory 13 C-fatty acid absorption in the distal parts of the small intestine (29,39,(41)(42)(43)(44).…”

Section: Discussionmentioning

confidence: 99%

Functional Development of Fat Absorption in Term and Preterm Neonates Strongly Correlates with Ability to Absorb Long-Chain Fatty Acids from Intestinal Lumen

Rings

Minich²,

Vonk³

et al. 2002

Pediatr Res

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Our goal for this study was to determine whether the maturation of fat absorption in neonatal life is functionally related to an increased ability to hydrolyze dietary fat, to absorb long-chain fatty acids, or to do both. In 16 preterm and in eight term neonates, the intestinal ability to hydrolyze triacylglycerols and the capacity to absorb long-chain fatty acids were determined at several times between birth and 5 mo after the term age. These processes were compared with the percentage of fat absorption (formula-fed infants) or with fecal fat excretion (breast-fed infants). The functional capacity to digest triacylglycerols and to absorb the lipolytic products was evaluated by measuring serum concentrations of the lipolytic product [1-13 C]palmitate after the enteral administration of tri-1-13 C palmitoyl-glycerol. Longchain fatty acids absorption (i.e. independent of lipolysis) was determined by measuring serum concentrations of [1-13 C]stearate after its enteral administration. The efficacy of fat absorption increased in preterm infants (formula-fed) from 91.2 Ϯ 1.1% (mean Ϯ SEM) at 32. Efficient absorption of fat from the diet is important for energy supply, growth, and development, especially during development (1). At the neonatal age, and particularly in the case of prematurity, a considerable part of dietary fat is not absorbed from the intestine, but is excreted via the feces (2-5). Fat absorption involves digestion, requiring lipolysis by lipolytic enzymes, and the subsequent intestinal absorption of the hydrolyzed fatty acids and monoacylglycerols (6). The uptake of lipolytic products encompasses intraluminal solubilization of lipolytic products, their subsequent translocation across the small intestine, and their incorporation into chylomicrons that are subsequently secreted into the lymph (7). The importance and relative contribution of incomplete digestion and a decreased ability for fatty acid absorption to the causes of increased fecal fat loss during (preterm) infancy is only partly understood. Several studies suggest that lipolysis of fats could be the rate-limiting step in (preterm) neonatal dietary fat absorption. In the human gastrointestinal system several lipases are active on dietary triacylglycerols: gastric lipase (8, 9), pancreatic (colipase-dependent) lipase (10, 11), and bile salt-stimulated lipase (12). Several investigators have demonstrated a decreased intraduodenal concentration of both pan-

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Section: Discussionmentioning

confidence: 99%

Functional Development of Fat Absorption in Term and Preterm Neonates Strongly Correlates with Ability to Absorb Long-Chain Fatty Acids from Intestinal Lumen

Rings

Minich²,

Vonk³

et al. 2002

Pediatr Res

Self Cite

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“…Saturated fatty acids are more dependent on solubilization than unsaturated fatty acids, due to the higher hydrophobicity of the former. The difference in bile salt dependency can be derived from absorption studies in rats with chronic bile diversion: in such an intestinal bile deficient condition, absorption of saturated fatty acids is below 30% of the ingested amount, while the absorption of unsaturated fatty acids is relatively maintained (~80%) [13]. Just like the digestion of fat, the process of micelle formation is also pH sensitive.…”

Section: Solubilizationmentioning

confidence: 99%

Persistent fat malabsorption in cystic fibrosis; lessons from patients and mice

Wouthuyzen-Bakker

Bodewes

Verkade

2011

Journal of Cystic Fibrosis

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Fat malabsorption in pancreatic insufficient cystic fibrosis (CF) patients is classically treated with pancreatic enzyme replacement therapy (PERT). Despite PERT, intestinal fat absorption remains insufficient in most CF patients. Several factors have been suggested to contribute to the persistent fat malabsorption in CF (CFPFM). We reviewed the current insights concerning the proposed causes of CFPFM and the corresponding intervention studies. Most data are obtained from studies in CF patients and CF mice. Based on the reviewed literature, we conclude that alterations in intestinal pH and intestinal mucosal abnormalities are most likely to contribute to CFPFM. The presently available data indicate that acid suppressive drugs and broad spectrum antibiotics could be helpful in individual CF patients for optimizing fat absorption and/or nutritional status.

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“…In fact, micellar solubilization increases the aqueous concentration of MG and FA 100 to 1000 times. The importance of this phase is underscored by a 30% reduction in dietary lipid absorption in patients with biliary atresia [136]. Similarly, rats with biliary drainage displayed reduced linoleic acid absorption [137].…”

Section: Intraluminal Abnormalitiesmentioning

confidence: 99%

Mechanisms of lipid malabsorption in Cystic Fibrosis: the impact of essential fatty acids deficiency

et al. 2005

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Transport mechanisms, whereby alimentary lipids are digested and packaged into small emulsion particles that enter intestinal cells to be translocated to the plasma in the form of chylomicrons, are impaired in cystic fibrosis. The purpose of this paper is to focus on defects that are related to intraluminal and intracellular events in this life-limiting genetic disorder. Specific evidence is presented to highlight the relationship between fat malabsorption and essential fatty acid deficiency commonly found in patients with cystic fibrosis that are often related to the genotype. Given the interdependency of pulmonary disease, pancreatic insufficiency and nutritional status, greater attention should be paid to the optimal correction of fat malabsorption and essential fatty acid deficiency in order to improve the quality of life and extend the life span of patients with cystic fibrosis.

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Bile diversion in rats leads to a decreased plasma concentration of linoleic acid which is not due to decreased net intestinal absorption of dietary linoleic acid

Cited by 26 publications

References 21 publications

Functional Development of Fat Absorption in Term and Preterm Neonates Strongly Correlates with Ability to Absorb Long-Chain Fatty Acids from Intestinal Lumen

Functional Development of Fat Absorption in Term and Preterm Neonates Strongly Correlates with Ability to Absorb Long-Chain Fatty Acids from Intestinal Lumen

Persistent fat malabsorption in cystic fibrosis; lessons from patients and mice

Mechanisms of lipid malabsorption in Cystic Fibrosis: the impact of essential fatty acids deficiency

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