Bile Composition in Patients with Chronic Renal Insufficiency

Marecková, O; Skála, I; Marecek, Z; Malý, Jan; Kocandrle, V; Schück, O; Bláha, Jan D.; Prát, V

doi:10.1093/ndt/5.6.423

Cited by 21 publications

(22 citation statements)

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“…One study in peritoneal dialysis patients showed that the prevalence of female gender, parathyroid hormone (PTH) levels, and serum creatinine levels was increased in patients having GBS, too (9). However, other studies did not confirm these results and could not find a correlation between PTH levels and GBS (2)(3)(4)(5)8). In the present study, we could not find a relationship between PTH levels, Ca, P, and Ca x P product and GBS either.…”

Section: Discussioncontrasting

confidence: 97%

“…Another small study on 11 regular HD patients showed increased bile cholesterol and increased saturation index, a decrease in primary, and an increase in secondary bile acids in the bile, which mimics the change in the spectrum of bile characteristics for cholecystolithiasis (8). There is no detailed information about the types of GBS in HD patients.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies revealed an increased prevalence of biliary lithiasis in hemodialysis (HD) patients compared to the healthy population (2,3). However, others reported similar incidences with normal populations (4,(6)(7)(8)(9). Besides the risk of complications, patients on dialysis treatment with asymptomatic GBS would have more severe complications related to GBS after transplantation (10).…”

Section: Introductionmentioning

confidence: 99%

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Increased frequency of gallbladder stone and related parameters in hemodialysis patients

Gençtoy

Ayidağa²,

Ergün³

et al. 2014

Turk J Gastroenterol

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Background/Aims: The prevalence of gallbladder stone (GBS) is shown to be increased in some studies in patients with chronic kidney disease (CKD). Nevertheless, some other studies did not confirm these findings. The controversial results about the prevalence of GBS in hemodialysis (HD) patients demand new studies to search GBS prevalence and associating risk factors in HD patients. In the present study, we aimed to investigate GBS prevalence and risk factors in our HD patients. Materials and Methods: A total of 104 HD and 149 control patients were involved. Complete physical examinations, including measurements of dry body weight and height, were done. Abdominal ultrasonography was conducted by the same experienced radiologist. Blood samples were drawn via venipuncture from the study participants after they had fasted overnight just before a midweek hemodialysis session for laboratory examinations. Results: The prevalence of GBS in HD patients was 34.6 % (36/104), and that was significantly higher than that of control group 12.9% (17/149; p=0.0001). In all study participants (HD patients and control group), patients with GBS were older than patients with no GBS (63.2±14.2 vs 53.7±16.7; p=0.0001). However, in HD patients, mean age was similar in patients with GBS and no GBS (64.3±13.8 vs 60.1±16.6; p>0.05). Patients with GBS had a higher prevalence of units of blood transfusions than patients with no GBS in hemodialysis patients (2.0±2.9 vs 0.9±1.3; p=0.047) Conclusion: The present study showed an increased prevalence of GBS in HD patients compared to healthy controls. The number of blood transfusions and autonomic neuropathy may be responsible for the increased prevalence of GBS in HD patients.

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Section: Discussioncontrasting

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Increased frequency of gallbladder stone and related parameters in hemodialysis patients

Gençtoy

Ayidağa²,

Ergün³

et al. 2014

Turk J Gastroenterol

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“…In man, literary data on the subject are scarce. Mareckova et al [4] in a study of patients with chronic renal failure maintained on a low-protein diet documented similar changes in bile composition to those found in animals. These changes were not detected in haemodialyzed (HD) patients on a normal protein intake.…”

Section: Introductionmentioning

confidence: 53%

“…The main factors in the pathogenesis of cholesterol GS are: (1) supersaturation of bile with cholesterol; (2) destabilization of bile, a function of the nature of bile acids of the micellar form, and (3) stasis of bile in the gallbladder [11]. Epidemiological studies have shown an increased prevalence of cholesterol GS to be associated with increasing age, female gender, parity, obesity, an inherited predisposition, diabetes mellitus, ileal disease, prolonged total parenteral nutrition, oral contraceptives, and low-protein diet [4]. The last mentioned is of particular relevance in patients with advanced chronic renal insufficiency.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Cholelithiasis in Non-Diabetic Haemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Korzets

Golan

Ben-Chitrit

et al. 1997

Nephron

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Haemodialyzed (HD) patients have been found to have an increased bile cholesterol level and an increased saturation index in bile. These changes were markedly enhanced in the presence of a low-protein diet. To evaluate whether such changes influence the prevalence of cholelithiasis in patients with end-stage renal failure, real-time sonography was performed to detect the presence of gallstones (GS) in 54 HD (28 males, 26 females, mean age 52.4 ± 15.4 years) and 39 continuous ambulatory peritoneal dialysis (CAPD; 22 males, 17 females, mean age 59.1 ± 14.9 years) patients. No patient had diabetes. The patients’ charts were reviewed for the following data: age, sex, primary renal disease, obesity (20% above ideal weight), history suggestive of gallbladder disease or previous cholecystectomy, duration of dialysis, and serum cholesterol levels. Overall, cholelithiasis was documented in 12 of 93 (12.9%) patients, 7 HD and 5 CAPD. When comparing the factors outlined above, no significant difference was found between HD and CAPD patient groups, either with or without cholelithiasis. Gallbladder disease was asymptomatic in all except 1 patient who required cholecystectomy. Using a healthy control group consisting of local age- and sex-matched inhabitants, GS were found in 8 of 134 (6%) of them (p > 0.05). We conclude that the prevalence rate of GS in our dialysis population (HD and CAPD) is similar to that of a local general population following a western-style diet, irrespective of dialysis mode.

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Vitamin D and gallstone disease—A population-based study

et al. 2016

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Gallstone disease is highly prevalent in the general population and is a major gastrointestinal cause of hospital admissions. The objectives were to determine whether circulating levels of 25-hydroxyvitamin D were associated to ultrasound proven gallstones or cholecystectomy in a general population sample. Determinants of vitamin D status were also explored. A random sample of 4130 people from the population of Copenhagen with ages 41-71 years were invited (N = 4130) and 2650 participants were included. Ultrasound examinations were performed to assess gallstone status and blood samples were drawn to assess 25-hydroxyvitamin D and biomarkers of renal and hepatic function. Gallstone disease was found in 422 participants. Associations were estimated by logistic regression models. Levels of 25-hydroxyvitamin D was not significantly associated with gallstone disease. Time of birth during low vitamin D exposure was associated with gallstone disease (gallstone prevalence 18.0 versus 14.4 %, odds ratio 1.33, 95 % confidence interval [1.07; 1.65]). Highest quartile of cystatin C was significantly associated with gallstone disease (gallstone prevalence 22.1 versus 12.0 %, odds ratio 1.53, 95 % confidence interval [1.08; 2.18]). Serum levels of creatinine and alanine amino transferase were not associated with gallstone disease. Sensitivity analyses excluding participants with cholecystectomy did not alter results significantly. No association between 25-hydroxyvitamin D and gallstone disease was identified. Findings suggest gallstones to be associated to low vitamin D exposure in utero and to renal failure suggesting that vitamin D might have an impact on gallstone disease. Future studies should explore associations for vitamin D and gallstone disease prospectively.

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Bile Composition in Patients with Chronic Renal Insufficiency

Cited by 21 publications

References 0 publications

Increased frequency of gallbladder stone and related parameters in hemodialysis patients

Increased frequency of gallbladder stone and related parameters in hemodialysis patients

Prevalence of Cholelithiasis in Non-Diabetic Haemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

Vitamin D and gallstone disease—A population-based study

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