Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

Shi, Li; Jin, Lihua; Huang, Wendong

doi:10.3390/cells12141888

Cited by 22 publications

(15 citation statements)

References 147 publications

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“…HFD consumption has been linked to BA metabolism disorders, which are characterized by elevated intestinal levels of cholic acid and deoxycholic acid. 47 Mice that were fed a diet containing deoxycholic acid exhibited increased gut permeability compared with mice that were fed a regular diet. 8 Reductions in ZO-1 and goblet and Paneth cells were also observed in Apc min/+ mice after deoxycholic acid treatment.…”

Section: ■ Discussionmentioning

confidence: 99%

Chlorogenic Acid/Linoleic Acid-Fortified Wheat-Resistant Starch Ameliorates High-Fat Diet-Induced Gut Barrier Damage by Modulating Gut Metabolism

Guo,

Chen,

Liu

et al. 2024

J. Agric. Food Chem.

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This study aimed to investigate alterations in gut microbiota and metabolites mediated by wheat-resistant starch and its repair of gut barrier dysfunction induced by a high-fat diet (HFD). Structural data revealed that chlorogenic acid (CA)/linoleic acid (LA) functioned through noncovalent interactions to form a more ordered structure and fortify antidigestibility in wheat starch (WS)-CA/LA complexes; the resistant starch (RS) contents of WS-CA, WS-LA, and WS-CA-LA complexes were 23.40 ± 1.56%, 21.25 ± 1.87%, and 35.47 ± 2.16%, respectively. Dietary intervention with WS-CA/LA complexes effectively suppressed detrimental alterations in colon tissue morphology induced by HFD and repaired the gut barrier in ZO-1 and MUC-2 levels. WS-CA/LA complexes could augment gut barrier-promoting microbes including Parabacteroides, Bacteroides, and Muribaculum, accompanied by an increase in short-chain fatty acids (SCFAs) and elevated expression of SCFA receptors. Moreover, WS-CA/LA complexes modulated secondary bile acid metabolism by decreasing taurochenodeoxycholic, cholic, and deoxycholic acids, leading to the activation of bile acid receptors. Collectively, this study offered guiding significance in the manufacture of functional diets for a weak gut barrier.

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Section: ■ Discussionmentioning

confidence: 99%

Chlorogenic Acid/Linoleic Acid-Fortified Wheat-Resistant Starch Ameliorates High-Fat Diet-Induced Gut Barrier Damage by Modulating Gut Metabolism

Guo,

Chen,

Liu

et al. 2024

J. Agric. Food Chem.

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“…A growing body of research has established a strong correlation between unregulated elevations in bile acid concentrations and a range of metabolic, in ammatory, and immune diseases and disorders. Gradually, the close relationship between bile acid metabolism and sepsis has been investigated in recent years, as knowledge of the role of the gut microbiome and metabolomics in sepsis has grown and become more comprehensive [14]. Bile acid transport and metabolism are disrupted at the onset of sepsis, and elevated bile acids in the body can be used as a class of DAMPs to activate the NLRP in ammasome signaling pathway in a calcium-dependent manner, thereby accelerating sepsis progression and contributing to its high mortality rates [15].…”

Section: Discussionmentioning

confidence: 99%

The utility of serum total bile acid levels as a prognostic biomarker for the survival of children with sepsis

Wang,

Deng,

Lin

et al. 2023

Preprint

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Background: Sepsis is common in pediatric intensive care units (ICU). It is crucial to explore the independent risk factors of sepsis, establish a septic prediction model, and evaluate the prognosis of hospitalized surviving patients with sepsis through clinical research. Methods: From January 2016 to December 2021, we selected septic children admitted to the ICU of the Children's Hospital, Zhejiang University School of Medicine. Concurrently, as controls for the absence of sepsis, healthy children of the same age were chosen. Every child was categorized into one of three groups based on the prognosis of sepsis: sepsis survival, sepsis death, or a control group with no sepsis. As the subject of the study, comprehensive clinical data of all children who were admitted to the hospital were collected. In order to identify prognostic risk factors for sepsis patients in the intensive care unit, the disparities in laboratory examination outcomes and clinical indicators of sepsis among the three groups of children were compared. Results:A total of 702 children were enrolled, including 538 cases in the sepsis survival group, 164 cases in the sepsis death group, and 269 cases in the no sepsis control group. Univariate and multivariate logistic regression analysis of in-hospital mortality showed that serum total bile acid (TBA) (OR=2.898, 95% CI 1.946~4.315, p<0.05) was a risk factor for sepsis. A clinical prediction model for sepsis prognosis was constructed based on the risk factors obtained from regression analysis. We found that TBA (>17.95 µmol/L) is an independent risk factor for predicting sepsis mortality, with an area under the curve (AUC) of 0.842 (95% CI 0.800-0.883), sensitivity of 54.9%, specificity of 96.6%, and HR=7.658 (95% CI 5.575~10.520). Conclusion: It is imperative to investigate the utilization of prognostic models for the purpose of forecasting mortality in children afflicted with sepsis. Based on the findings of this study, elevated serum TBA concentrations are associated with a heightened risk of mortality in pediatric sepsis. By constructing a survival prediction model from clinical data, the final analysis can assist clinicians caring for children with sepsis at the bedside.

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“…Bile acids play an essential role in many aspects of the maintenance of intestinal barrier integrity 80 . Alteration of the bile acid profile changes the intestinal permeability and affects the barrier function by regulating tight junction protein expression 80 .…”

Section: Immune Regulation By Microbiome Metabolitesmentioning

confidence: 99%

“…79 Bile acids play an essential role in many aspects of the maintenance of intestinal barrier integrity. 80 Alteration of the bile acid profile changes the intestinal permeability and affects the barrier function by regulating tight junction protein expression. 80 High-fat diet, which profoundly affects both the composition of the microbiota and of the bile acids pool, was shown to increase mucosal permeability by reducing the expression of occludin, antimicrobial peptide RegIIIβ, and IL-22.…”

Section: Innate Immune Cellsmentioning

confidence: 99%

A cross talk between microbial metabolites and host immunity: Its relevance for allergic diseases

Losol,

Wolska,

Wypych

et al. 2024

Clinical & Translational All

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BackgroundAllergic diseases, including respiratory and food allergies, as well as allergic skin conditions have surged in prevalence in recent decades. In allergic diseases, the gut microbiome is dysbiotic, with reduced diversity of beneficial bacteria and increased abundance of potential pathogens. Research findings suggest that the microbiome, which is highly influenced by environmental and dietary factors, plays a central role in the development, progression, and severity of allergic diseases. The microbiome generates metabolites, which can regulate many of the host’s cellular metabolic processes and host immune responses.Aims and MethodsOur goal is to provide a narrative and comprehensive literature review of the mechanisms through which microbial metabolites regulate host immune function and immune metabolism both in homeostasis and in the context of allergic diseases.Results and DiscussionWe describe key microbial metabolites such as short‐chain fatty acids, amino acids, bile acids and polyamines, elucidating their mechanisms of action, cellular targets and their roles in regulating metabolism within innate and adaptive immune cells. Furthermore, we characterize the role of bacterial metabolites in the pathogenesis of allergic diseases including allergic asthma, atopic dermatitis and food allergy.ConclusionFuture research efforts should focus on investigating the physiological functions of microbiota‐derived metabolites to help develop new diagnostic and therapeutic interventions for allergic diseases.

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Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

Cited by 22 publications

References 147 publications

Chlorogenic Acid/Linoleic Acid-Fortified Wheat-Resistant Starch Ameliorates High-Fat Diet-Induced Gut Barrier Damage by Modulating Gut Metabolism

Chlorogenic Acid/Linoleic Acid-Fortified Wheat-Resistant Starch Ameliorates High-Fat Diet-Induced Gut Barrier Damage by Modulating Gut Metabolism

The utility of serum total bile acid levels as a prognostic biomarker for the survival of children with sepsis

A cross talk between microbial metabolites and host immunity: Its relevance for allergic diseases

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