Bile Acids in the Assessment of Hepatocellular Function

Thompson, Miles D.

doi:10.1177/019262339602400109

Cited by 22 publications

(15 citation statements)

References 114 publications

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“…In general, bile acid concentrations had ≥ twofold increases in the higher-dose groups compared to concurrent vehicle controls. Increases of this magnitude are indicative of impaired bile flow or (intrahepatic) cholestasis, the causes of which include physical disruption of bile flow through the biliary system or perturbation of bile acid formation and excretion at the cellular level 109 . Direct bilirubin concentration, another marker of cholestasis, was minimally elevated in the high-dose groups of PFBS and PFOS.…”

Section: Discussionmentioning

confidence: 99%

NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate Potassium Salt, and Perfluorooctane Sulfonic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats

2019

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Section: Discussionmentioning

confidence: 99%

NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate Potassium Salt, and Perfluorooctane Sulfonic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats

2019

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“…In general, bile acid concentrations in PFDA and PFNA studies had greater than a threefold increase in the higher-dose groups compared to concurrent vehicle controls. Increases of this magnitude are indicative of impaired bile flow or (intrahepatic) cholestasis, the causes of which include physical disruption of bile flow through the biliary system or perturbation of bile acid formation and excretion at the cellular level 135 . In addition, total bilirubin concentration, another marker of cholestasis, was substantially elevated in most high-dose PFNA and PFDA groups.…”

Section: Discussionmentioning

confidence: 99%

NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats

2019

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“…UDCA has been isolated from polar bear bile (Kurozumi, Harano & Ayaki 1974) and used to treat cholestatic liver disease in humans (Hofman 1984). UDCA has many reported pharmacological effects for humans, such as improvement of liver function, digestion and absorption of dietary lipid and fat‐soluble vitamins by stimulating bile secretion (Ward, Brogden, Heel, Speight & Avery 1984; Heller, Martinet, Henrion, Schapira & Gallez 1990; Thompson 1996). In mammals, UDCA can modulate immunoglobulin (Ig) expression not only qualitatively, but also quantitatively (Zuchner, Sternsdorf, Szostecki, Heathcote, Cauch & Will 1997).…”

Section: Introductionmentioning

confidence: 99%

Effects of ursodeoxycholic acid on growth and digestive enzyme activities of Japanese flounderParalichthys olivaceus(Temminck & Schlegel)

Alam

Teshima

Ishikawa

et al. 2001

Aquaculture Research

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Three experiments were conducted to elucidate the effects of ursodeoxycholic acid (UDCA) on growth performance and digestive enzyme activities of Japanese¯ounder Paralichthys olivaceus (Temminck & Schlegel) juveniles and larvae. In experiment 1 (growth study), duplicate groups of juveniles of about 7 g initial body weight were fed a UDCA diet (containing 0.025% UDCA) and a control diet (without UDCA) to apparent satiation twice a day for 6 weeks at 18±21°C. In experiment 2 (enzyme study), triplicate groups of juveniles (7 g) were also fed the UDCA and control diets for 6 weeks under similar feeding and water management conditions to those for the growth study, digestive organs were collected every 2 weeks and their enzyme (aamylase, lipase and protease) activities were assayed. In experiment 3, duplicate groups of 48day-old larvae were fed two test microdiets (UDCA and control diets) for 30 min and assayed for enzyme activities 6, 12, 24, 36 and 48 h after a single feeding in the morning. The weight gain and feed conversion ef®ciency of the juveniles fed the UDCA diet in the growth study did not show any signi®cant difference compared to juveniles fed the control diet. Total lipids, neutral lipids and triglycerides of the whole body and apparent body retention (%) of dietary lipids were notably higher (P < 0.05) in the UDCA group than the control. In the juveniles fed the UDCA diet, the activities of a-amylase and protease did not increase with holding time compared to the control diet. Lipase activity of the juveniles fed the UDCA diet was signi®cantly higher than those fed the control diet. By contrast, the activities of a-amylase, lipase and protease of the larvae at 6, 12, 24, 36 and 48 h after ®nal feeding did not show any difference between the dietary groups. These results suggest that UDCA may have an important role in lipid assimilation by increasing enzyme activity of the juvenile Japanese¯ounder, but there are few effects on growth performance of the juveniles and digestive enzyme activities of the larvae.

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Bile Acids in the Assessment of Hepatocellular Function

Cited by 22 publications

References 114 publications

NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate Potassium Salt, and Perfluorooctane Sulfonic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats

NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate Potassium Salt, and Perfluorooctane Sulfonic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats

NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats

Effects of ursodeoxycholic acid on growth and digestive enzyme activities of Japanese flounderParalichthys olivaceus(Temminck & Schlegel)

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