Bile Acids as Signaling Molecules

Claudel, Thierry; Trauner, Michael

doi:10.1002/9781119436812.ch25

Cited by 4 publications

(1 citation statement)

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“…Compensatory mechanisms lead to an intensified inflammatory response and increased proliferation, which is qualified as early tumor development. Furthermore, bile acids activate the muscarinic M3 receptor [91][92][93]. Its stimulation induces metalloproteinase activity and the Wnt/B-catenin signaling pathway, which in turn increases the metastatic potential as well as the proliferation and survival of colon cancer cells.…”

Section: Fabps: Fatty Acid-binding Proteinsmentioning

confidence: 99%

Important players in carcinogenesis as potential targets in cancer therapy: an update

2020

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The development of cancer is a problem that has accompanied mankind for years. The growing number of cases, emerging drug resistance, and the need to reduce the serious side effects of pharmacotherapy are forcing scientists to better understand the complex mechanisms responsible for the initiation, promotion, and progression of the disease. This paper discusses the modulation of the particular stages of carcinogenesis by selected physiological factors, including: acetylcholine (ACh), peroxisome proliferator-activated receptors (PPAR), fatty acid-binding proteins (FABPs), Bruton's tyrosine kinase (Btk), aquaporins (AQPs), insulin-like growth factor-2 (IGF-2), and exosomes. Understanding their role may contribute to the development of more effective and safer therapies based on new binding sites.

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Section: Fabps: Fatty Acid-binding Proteinsmentioning

confidence: 99%