Bile acids as carcinogens in human gastrointestinal cancers

Bernstein, Harris; Bernstein, Carol; Payne, Claire M.; Dvořáková, Kateřina; Garewal, Harinder S.

doi:10.1016/j.mrrev.2004.08.001

Cited by 515 publications

(418 citation statements)

References 145 publications

Supporting

Mentioning

394

Contrasting

Unclassified

Order By: Relevance

“…Bile acids are synthesized from cholesterol mostly in the liver, and an increased incidence of colorectal cancer is associated with high levels of bile acids. Thus, bile acids may function as cancer promoters in the colon (Bernstein et al, 2005).…”

Section: Colorectal Cancermentioning

confidence: 99%

Cholesterol lowering: role in cancer prevention and treatment

Murai

2014

Biological Chemistry

160

131

View full text Add to dashboard Cite

Abstract:The accumulation of cholesterol is a general feature of cancer tissue, and recent evidence suggests that cholesterol plays critical roles in the progression of cancers, including breast, prostate, and colorectal cancers. The dysregulation of metabolic pathways, including those involved in cholesterol biosynthesis, is implicated in tumor development and cancer progression. Lipid rafts are highly dynamic cholesterol-enriched domains of the cell membrane, involved in various cellular functions, including the regulation of transmembrane signaling at the cell surface. It was recently demonstrated that lipid rafts also play critical roles in cancer cell adhesion and migration. This review focuses on our current understanding of how cholesterol regulation, lipid rafts, and dysregulated cholesterol biosynthesis contribute to cancer development and progression, and the therapeutic potential of cholesterol lowering for cancer prevention and treatment.

show abstract

Section: Colorectal Cancermentioning

confidence: 99%

Cholesterol lowering: role in cancer prevention and treatment

Murai

2014

Biological Chemistry

160

131

View full text Add to dashboard Cite

show abstract

“…Clinical studies have identified several primary bile acids as well as the secondary bile acid, deoxycholate, in the refluxate of BE patients [12]. Bile acids cause oxidative stress, DNA damage, and apoptosis [13]. Normal squamous epithelium is sensitive to induction of apoptosis by deoxycholate, whereas BE metaplasia is apoptosis-resistant [14].…”

Section: Esophageal Adenocarcinomamentioning

confidence: 99%

“…A high fat, low fiber Western style diet, as well as elevated fecal bile acid concentration are important risk factors for colon cancer (reviewed in [13]). Bile acids induce oxidative/ nitrosative stress, DNA damage and apoptosis in the colonic epithelium [13].…”

Section: Colon Cancermentioning

confidence: 99%

“…Bile acids induce oxidative/ nitrosative stress, DNA damage and apoptosis in the colonic epithelium [13]. Epithelial cells of the flat non-neoplastic colonic mucosa of individuals with colon cancer often have reduced capacity to undergo induction of apoptosis by bile acid compared to epithelial cells of individuals without neoplasia [42,[57][58][59].…”

Section: Colon Cancermentioning

confidence: 99%

See 1 more Smart Citation

Field defects in progression to gastrointestinal tract cancers

Bernstein

Payne

et al. 2008

Cancer Letters

View full text Add to dashboard Cite

A field of defective tissue may represent a pre-malignant stage in progression to many cancers. However, field defects are often overlooked in studies of cancer progression through assuming tissue at some distance from the cancer is normal. We indicate, however, the generality of field defects in gastrointestinal cancers, including cancers of the oropharynx, esophagus, stomach, bile duct, pancreas, small intestine and colon/rectum. Common features of these field defects are reduced apoptosis competence, aberrant proliferation and genomic instability. These features are often associated with high bile acid exposure and may explain the association of dietary-related factors with cancer progression.

show abstract

“…Evidence reviewed by Bernstein et al . suggests that bile acids act as carcinogens in human gastrointestinal cancers 15. Most benign and malignant tumors of the small intestine and extrahepatic bile ducts arise in the region of the Papilla of Vater.…”

Section: Discussionmentioning

confidence: 99%

Proton pump inhibitors and risk of periampullary cancers—A nested case–control study

Chien

Huang

Shao

et al. 2015

Intl Journal of Cancer

View full text Add to dashboard Cite

Considerable attention has been focused on long‐term use of proton pump inhibitor (PPI) medications in relation to increased risk of cancer via stimulation of DNA‐damaged cells. The aim of this study is to examine the dose‐dependent effect of PPI on periampullary cancers in a national population‐based cohort. A nested case–control analysis was constructed based on Taiwan's National Health Insurance Research Database and the Taiwan Cancer Registry between the years 2000 and 2010. Cases involving patients diagnosed with periampullary cancers were selected and controls were matched to cases according to age, sex and observational period. A “PPI user” was defined as any patient receiving more than 28 cumulative defined daily doses as measured by prescription drug claims. Conditional logistic regression analysis was conducted to calculate odds ratios (ORs) and 95% confidence intervals (CIs) according to the level of PPI exposure. A total of 7,681 cases and 76,762 matched controls were included with a mean follow‐up period of 6.6 years (SD: 2.0). The odds of PPI exposure in patients with periampullary cancers were higher than that of control patients with an adjusted OR of 1.35 (95% CIs: 1.16–1.57). Our results also showed that PPI exposure was slightly linked to periampullary cancers in dose‐dependent manner. A similar association was observed in patients who solely took PPI but no eradication therapy for Helicobacter pylori infection. Long‐term PPI use was associated with an increased risk of periampullary cancers in the current population‐based study. Physicians must weigh potential risks of long‐term maintenance against therapeutic benefit.

show abstract

Bile acids as carcinogens in human gastrointestinal cancers

Cited by 515 publications

References 145 publications

Cholesterol lowering: role in cancer prevention and treatment

Cholesterol lowering: role in cancer prevention and treatment

Field defects in progression to gastrointestinal tract cancers

Proton pump inhibitors and risk of periampullary cancers—A nested case–control study

Contact Info

Product

Resources

About