“…On one hand, more general subjects covering various pathogenic viruses and related research areas have been targeted as well. Of socially important pathogenic viruses, some are solely tropic for humans, HIV-1 as an example (Hatziioannou et al, 2006(Hatziioannou et al, , 2009Kamada et al, 2006;Nomaguchi et al, 2008Nomaguchi et al, , 2013b, and some like human norovirus are known not to replicate in cultured cells (Duizer et al, 2004;Herbst-Kralovetz et al, 2013;Ettayebi et al, 2016;Murakami et al, 2020). Indeed, these viral properties hamper and limit our experimental strategies, and are representing major study projects to overcome in the virology.…”