2015
DOI: 10.1016/j.bbagrm.2014.05.021
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Bile acid signaling and liver regeneration

Abstract: The liver is able to regenerate itself in response to partial hepatectomy or liver injury. This is accomplished by a complex network of different cell types and signals both inside and outside the liver. Bile acids (BAs) are recently identified as liver-specific metabolic signals and promote liver regeneration by activating their receptors: Farnesoid X Receptor (FXR) and G-protein-coupled BA receptor 1 (GPBAR1, or TGR5). FXR is a member of the nuclear hormone receptor superfamily of ligand-activated transcript… Show more

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Cited by 90 publications
(78 citation statements)
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“…It's well known that bile acid/FXR signaling pathway is required for normal liver re-generation. When liver is injured, FXR activation results in the suppression of CYP7al by inducing its negative regulator SHP, which help rapidly decrease hepatic BA levels to protect the liver from apoptosis and necrosis induced by elevated BA concentrations [33,44,45]. Although we are not clear how deficiency of SREBP-1c caused induction of SHP (Fig.…”
Section: Discussionmentioning
confidence: 83%
“…It's well known that bile acid/FXR signaling pathway is required for normal liver re-generation. When liver is injured, FXR activation results in the suppression of CYP7al by inducing its negative regulator SHP, which help rapidly decrease hepatic BA levels to protect the liver from apoptosis and necrosis induced by elevated BA concentrations [33,44,45]. Although we are not clear how deficiency of SREBP-1c caused induction of SHP (Fig.…”
Section: Discussionmentioning
confidence: 83%
“…Based on a wealth of studies, including genetically modified mouse models, it was postulated that the innate immune system would ''prime'' hepatocytes to respond to the mitogenic action of growth factors, while fluctuations in the levels of key metabolites such as glucose, fatty acids and triglycerides, amino acids and its derivatives such as S-adenosylmethionine, and particularly bile acids would contribute to the onset and termination of the regenerative response after partial liver resection [128][129][130][131][132][133][134][135][136][137]. Nuclear receptors such as PPARa, PPARc, CAR, LXR and the bile acid receptor, FXR, are increasingly recognized as modulators of hepatocyte proliferation during liver regeneration.…”
Section: Regulation Of Hepatocellular Quiescence and Proliferationmentioning
confidence: 99%
“…After injury or surgical removal of the cause of injury, liver cells quickly begin to proliferate and recover the lost organ weight (Cienfuegos et al, 2014). Post-hepatectomy liver tissue homogenates are likely to include all necessary stimulating factors and nutrients (Karkampouna et al, 2012;Maruyama and Ohkohchi, 2012;Kedarisetty et al, 2014;Fan et al, 2015). The present study used homogenates generated following partial resection of rat liver tissue to analyze the combined action of liver cell growth factors and hormones on stem cell differentiation.…”
Section: Discussionmentioning
confidence: 99%