Bile acid-based receptors and their applications in recognition

Synthesis and Hemolytic Activity of Bile Acid-Indole Bioconjugates Linked by Triazole

“…The docked molecules possess a non-negligible affinity to the 2Q85 protein domain, implying that they could be suitable inhibitors. Each figure (Figures 8,10,12,14,16,and 18) shows binding energies with a specified kcal/mol unit. Despite forming a lower number of possible hydrogen bonds, the affinities of structures 16, 18, and 20 (Figure 4) for the 5V5Z protein domain are even a little stronger than those of the 2Q85 domain.…”

“…Among steroids, cholesterol is a crucial component of the animal cell membrane − and a substrate for synthesizing vitamin D, bile acid, and steroid hormones. − Steroids vary in the presence of different functional groups. Due to their biological significance and chemical properties, steroids and their derivatives are widely used in biomimetic chemistry, host––guest chemistry, and pharmacology. , As structural building blocks, bile acids are used in constructing molecular receptors, and their dimers are employed in developing macrocyclic artificial receptors that exhibit good organogellation properties. − …”

Functionalized Schiff-base containing phenothiazine and cholic acid as a paper-based fluorescence turn-off sensor for Sn(ii) ion detection and its application

“…The amphiphilic qualities of bile acids provide diversity in terms of solubility, transport, membrane permeability, and self-assembly, which has led to a recent surge in research on bile acid-based chemosensors. 35 Their dual capability to function in hydrophilic and hydrophobic conditions renders them indispensable in the development of metal ion sensors. In metal ion sensing, bile acid rigidity is important because it allows for specific binding interactions that are necessary for sensor performance.…”

A new pyridoxal-derived gelator for selective recognition of CN− and F− under different conditions

“…Further, these two ions ARTICLE Journal Name 2 | J. Name., 2012, 00, [1][2][3] This journal is © The Royal Society of Chemistry 20xx…”

“…Design and synthesis of new molecular architectures built on biologically relevant compounds has garnered continued interest in molecular recognition research. [1][2][3] Of the different biologically important compounds, pyridoxal (vitamin B 6 cofactor) has attracted attention owing to its good coordinating and photophysical properties. Its use as a metal ion binder in recognition studies is well discussed through various designs in the literature.…”