Bile acid and cholesterol excretion in human beings given soya-bean-and meat-protein-based diets: a study in ileostomy subjects

Abstract

1. The effect of partial replacement of meat protein with three different soya-bean-protein products on bile acid and cholesterol excretion was studied in seven ileostomy subjects. Four different test diets containing 60 g meat, rice and bread protein, or a replacement of 250 g protein/kg total dietary protein by soya-bean protein from soyabean flour, soya-bean concentrate or soya-bean isolate, were randomly assigned to the subjects in 2-d periods.2. Ileostomy contents were collected at 2-h intervals during the day and in one portion during the night, and immediately deep-frozen to avoid bacteriological degradation. Bile acids and cholesterol were quantified by gas-liquid chromatography.3. No difference in daily excretion of bile acids and cholesterol was noted between test diets. Ileostomy sterol concentrations were lower when soya-bean products were fed.4. Incorporation of moderate amounts of soya-bean products in solid diets does not seem to affect short-term sterol balance in man.

Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review

“…Higaki et al [87] reported that a soybean protein resistant to digestion captures bile acids and stimulates faecal bile acid excretion applying in vitro testing and a rat model. On the other hand, Bosaeus et al [88] investigated soy bean proteins as alternatives to meat proteins and did not find significant influences on ileostomy bile acid concentrations. A recent study of Wang and Fan [89] focused on structural characteristics of the interaction between zein, a plant protein isolated from maize, and sodium taurocholate.…”