Bilayered HA/CS/PEGDA hydrogel with good biocompatibility and self-healing property for potential application in osteochondral defect repair

You, Baihao; Li, Qingtao; Dong, Hua; Huang, Tao; Cao, Xiaodong; Liao, Hua

doi:10.1016/j.jmst.2017.11.016

Cited by 51 publications

(19 citation statements)

References 53 publications

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“…In medicine, 3D printing can be used to develop and manufacture individual products adapted to the human organism, such as for surgical applications [1], orthosis [2], drug delivery systems [3] and implants [4]. For medical applications, it is essential that the materials used for this purpose have defined mechanical properties as well as biocompatibility [5,6]. One of these materials are polymers.…”

Section: Introductionmentioning

confidence: 99%

Material investigations on poly(ethylene glycol) diacrylate-based hydrogels for additive manufacturing considering different molecular weights

Klimaschewski

Küpperbusch

Kunze

et al. 2022

Journal of Mechanical and Energy Engineering

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The aim of this case study is to generate several poly(ethylene glycol) diacrylate-based hydrogels using additive manufacturing process and compare their material properties. A commercial stereolithography system is used to produce the test specimens in accordance with ISO standards. Three formulations will be prepared for this purpose. The basis in each case is PEGDA with average molecular weights of 700 Mn, 575 Mn and 250 Mn. A photoinitiator and an UV absorber are added to ensure spatial and temporal crosslinking. Subsequently, the formulations are investigated for their material properties according to ISO standards by means of tensile, compression and hardness tests, and the influence of the molecular weights is determined.

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Section: Introductionmentioning

confidence: 99%

Material investigations on poly(ethylene glycol) diacrylate-based hydrogels for additive manufacturing considering different molecular weights

Klimaschewski

Küpperbusch

Kunze

et al. 2022

Journal of Mechanical and Energy Engineering

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“…The addition of synthetic polymers to hydrogel scaffolds can increase their mechanical properties. One such example used PEGDA with HyA and chitosan for AC repair, with nHA included to regenerate SCB [89]. This hydrogel exhibited self-healing capacities and could be advantageous in an environment with high compressive and shearing forces, such as an articular joint.…”

Section: Composite Natural/synthetic Polymer-based Approaches To Oste...mentioning

confidence: 99%

The development of natural polymer scaffold-based therapeutics for osteochondral repair

Lemoine

Casey

O’Byrne

et al. 2020

Biochemical Society Transactions

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Due to the limited regenerative capacity of cartilage, untreated joint defects can advance to more extensive degenerative conditions such as osteoarthritis. While some biomaterial-based tissue-engineered scaffolds have shown promise in treating such defects, no scaffold has been widely accepted by clinicians to date. Multi-layered natural polymer scaffolds that mimic native osteochondral tissue and facilitate the regeneration of both articular cartilage (AC) and subchondral bone (SCB) in spatially distinct regions have recently entered clinical use, while the transient localized delivery of growth factors and even therapeutic genes has also been proposed to better regulate and promote new tissue formation. Furthermore, new manufacturing methods such as 3D bioprinting have made it possible to precisely tailor scaffold micro-architectures and/or to control the spatial deposition of cells in requisite layers of an implant. In this way, natural and synthetic polymers can be combined to yield bioactive, yet mechanically robust, cell-laden scaffolds suitable for the osteochondral environment. This mini-review discusses recent advances in scaffolds for osteochondral repair, with particular focus on the role of natural polymers in providing regenerative templates for treatment of both AC and SCB in articular joint defects.

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“…By combining the merits of hydrogel and foam dressings, this hydrogel foam has the potential to provide a universal chronic wound treatment to treat both dehydrated and highly exudating chronic wounds. The hydrogel foam was fabricated from polyethylene glycol diacrylate (PEGDA), which has been widely used in various biomedical engineering applications 42–46 . The hydrophilic PEGDA polymer network allows for the absorption and preservation of high water content, providing the exudate removal and water retention required for wound moisture control.…”

Section: Introductionmentioning

confidence: 99%

High porosity PEG‐based hydrogel foams with self‐tuning moisture balance as chronic wound dressings

Lan

Kar

Chwatko

et al. 2023

J Biomedical Materials Res

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A major challenge in chronic wound treatment is maintaining an appropriate wound moisture balance throughout the healing process. Wound dehydration hinders wound healing due to impeded molecule transport and cell migration with associated tissue necrosis. In contrast, wounds that produce excess fluid contain high levels of reactive oxygen species and matrix metalloproteases that impede cell recruitment, extracellular matrix reconstruction, and angiogenesis. Dressings are currently selected based on the relative amount of wound exudate with no universal dressing available that can maintain appropriate wound moisture balance to enhance healing. This work aimed to develop a high porosity poly(ethylene glycol) diacrylate hydrogel foam that can both rapidly remove exudate and provide self‐tuning moisture control to prevent wound dehydration. A custom foaming device was used to vary hydrogel foam porosity from 25% to 75% by adjusting the initial air‐to‐solution volume ratio. Hydrogel foams demonstrated substantial improvements in water uptake volume and rate as compared to bulk hydrogels while maintaining similar hydration benefits with slow dehydration rates. The hydrogel foam with the highest porosity (~75%) demonstrated the greatest water uptake and rate, which outperformed commercial dressing products, Curafoam® and Silvercel®, in water absorption, moisture retention, and exudate management. Investigation of the water vapor transmission rates of each dressing at varied hydration levels was characterized and demonstrated the dynamic moisture‐controlling capability of the hydrogel foam dressing. Overall, the self‐tuning moisture control of this hydrogel foam dressing holds great promise to improve healing outcomes for both dry and exudative chronic wounds.

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Bilayered HA/CS/PEGDA hydrogel with good biocompatibility and self-healing property for potential application in osteochondral defect repair

Cited by 51 publications

References 53 publications

Material investigations on poly(ethylene glycol) diacrylate-based hydrogels for additive manufacturing considering different molecular weights

Material investigations on poly(ethylene glycol) diacrylate-based hydrogels for additive manufacturing considering different molecular weights

The development of natural polymer scaffold-based therapeutics for osteochondral repair

High porosity PEG‐based hydrogel foams with self‐tuning moisture balance as chronic wound dressings

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