Bilayer nanostructure coated AZ31 magnesium alloy implants: in vivo reconstruction of critical-sized rabbit femoral segmental bone defect

Perumal, Govindaraj; Ramasamy, Boopalan; A, Maya Nandkumar; Sivaraman, D.; Selvaraj, Raja; Doble, Mukesh

doi:10.1016/j.nano.2020.102232

Cited by 18 publications

(10 citation statements)

References 61 publications

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“…Additionally, PCL coating can improve the safety of the graft due to its good biocompatibility. 191 However, PCL has a smooth surface, high hydrophobicity, and poor biological activity, which are not conducive to osteoblast adhesion and bone tissue regeneration. 192 Metal ions can improve the biological activity of PCL coating, and PCL coating can improve the safety of metal ions due to its good biocompatibility.…”

Section: Treating Bone Defects Without Infectionmentioning

confidence: 99%

Application of bioactive metal ions in the treatment of bone defects

Cui

et al. 2022

J. Mater. Chem. B

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Section: Treating Bone Defects Without Infectionmentioning

confidence: 99%

Application of bioactive metal ions in the treatment of bone defects

Cui

et al. 2022

J. Mater. Chem. B

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“…The electrospinning procedure was carried out as per our earlier reported procedure with slight modifications. , The nanofibers collection time was carried out for 2 h, subsequently the deposited electrospun fibers of PCL and PCL/HPG/nHA (PHNH) from the collector plate were carefully detached. The fabricated electrospun nanofibers was kept overnight in a vacuum desiccator for drying.…”

Section: Methodsmentioning

confidence: 99%

Controlled Synthesis of Dendrite-like Polyglycerols Using Aluminum Complex for Biomedical Applications

et al. 2023

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This work describes a one-pot synthesis of dendrite-like hyperbranched polyglycerols (HPGs) via a ring-opening multibranching polymerization (ROMBP) process using a bis(5,7-dichloro-2-methyl-8-quinolinolato)methyl aluminum complex ( 1 ) as a catalyst and 1,1,1-tris(hydroxymethyl)propane/trimethylol propane (TMP) as an initiator. Single-crystal X-ray diffraction (XRD) analysis was used to elucidate the molecular structure of complex 1 . Inverse-gated (IG) 13 C NMR analysis of HPGs showed degree of branching between 0.50 and 0.57. Gel permeation chromatography (GPC) analysis of the HPG polymers provided low, medium, and high-molecular weight ( M n ) polymers ranging from 14 to 73 kDa and molecular weight distributions ( M w / M n ) between 1.16 and 1.35. The obtained HPGs exhibited high wettability with water contact angle between 18 and 21° and T g ranging between −39 and −55 °C. Notably, ancillary ligand-supported aluminum complexes as catalysts for HPG polymerization reactions have not been reported to date. The obtained HPG polymers in the presence of the aluminum complex ( 1 ) can be used for various biomedical applications. Here, nanocomposite electrospun fibers were fabricated with synthesized HPG polymer. The nanofibers were subjected to cell culture experiments to evaluate cytocompatibility behavior with L929 and MG63 cells. The cytocompatibility studies of HPG polymer and nanocomposite scaffold showed high cell viability and spreading. The study results concluded, synthesized HPG polymers and composite nanofibers can be used for various biomedical applications.

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“…Additionally, the uncoated sample exhibited poor cell adhesion, while the cells flattened and expanded on the composite coated sample due to the characteristic coating morphology, as shown in Figure 8. Perumal et al (2020) prepared a bilayer coating of PCL/nHA by dip coating followed by electrospinning on an AZ31 cage implant and studied the in vivo behavior of New Zealand white rabbits. The in vivo test results showed enhanced bone healing and controlled biodegradation of the implant at the diseased site.…”

Section: Electrospinningmentioning

confidence: 99%

Recent Progress in Surface Modification of Mg Alloys for Biodegradable Orthopedic Applications

et al. 2022

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The combination of light weight, strength, biodegradability, and biocompatibility of magnesium (Mg) alloys can soon break the paradigm for temporary orthopedic implants. As the fulfillment of Mg-based implants inside the physiological environment depends on the interaction at the tissue–implant interface, surface modification appears to be a more practical approach to control the rapid degradation rate. This article reviews recent progress on surface modification of Mg-based materials to tailor the degradation rate and biocompatibility for orthopedic applications. A critical analysis of the advantages and limitations of the various surface modification techniques employed are also included for easy reference of the readers.

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Bilayer nanostructure coated AZ31 magnesium alloy implants: in vivo reconstruction of critical-sized rabbit femoral segmental bone defect

Cited by 18 publications

References 61 publications

Application of bioactive metal ions in the treatment of bone defects

Application of bioactive metal ions in the treatment of bone defects

Controlled Synthesis of Dendrite-like Polyglycerols Using Aluminum Complex for Biomedical Applications

Recent Progress in Surface Modification of Mg Alloys for Biodegradable Orthopedic Applications

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