“…The antibacterial mechanism of inorganic antimicrobial agents is widely assumed to involve the release of antimicrobial ions to destroy bacteria; however, the continuous release of bactericidal ions often results in severe cytotoxicity and environmental concerns. To address these disadvantages of current materials, new effective, safe, environmentally benign and economical antibacterial materials must be developed soon ( Wang R. et al, 2021 ).…”
Section: Combined Application Of Mao and Other Treatment Methodsmentioning
confidence: 99%
“…The tungsten-containing MAO coating effectively hindered bacterial attachment, reduced the number of planktonic bacteria in the culture media, and hinted at the antibacterial action of the coating. To explore the antibacterial mechanism of tungsten-doped TiO 2 coatings, Wang R. et al (2021) used MAO technology to coat the surface of Ti6Al4V with tungsten-doped TiO 2 with antibacterial properties. The microstructure of tungsten-doped and undoped TiO 2 coatings was studied and compared.…”
Section: Combined Application Of Mao and Other Treatment Methodsmentioning
Titanium and titanium alloy implants are essential for bone tissue regeneration engineering. The current trend is toward the manufacture of implants from materials that mimic the structure, composition and elasticity of bones. Titanium and titanium alloy implants, the most common materials for implants, can be used as a bone conduction material but cannot promote osteogenesis. In clinical practice, there is a high demand for implant surfaces that stimulate bone formation and accelerate bone binding, thus shortening the implantation-to-loading time and enhancing implantation success. To avoid stress shielding, the elastic modulus of porous titanium and titanium alloy implants must match that of bone. Micro-arc oxidation technology has been utilized to increase the surface activity and build a somewhat hard coating on porous titanium and titanium alloy implants. More recently, a growing number of researchers have combined micro-arc oxidation with hydrothermal, ultrasonic, and laser treatments, coatings that inhibit bacterial growth, and acid etching with sand blasting methods to improve bonding to bone. This paper summarizes the reaction at the interface between bone and implant material, the porous design principle of scaffold material, MAO technology and the combination of MAO with other technologies in the field of porous titanium and titanium alloys to encourage their application in the development of medical implants.
“…The antibacterial mechanism of inorganic antimicrobial agents is widely assumed to involve the release of antimicrobial ions to destroy bacteria; however, the continuous release of bactericidal ions often results in severe cytotoxicity and environmental concerns. To address these disadvantages of current materials, new effective, safe, environmentally benign and economical antibacterial materials must be developed soon ( Wang R. et al, 2021 ).…”
Section: Combined Application Of Mao and Other Treatment Methodsmentioning
confidence: 99%
“…The tungsten-containing MAO coating effectively hindered bacterial attachment, reduced the number of planktonic bacteria in the culture media, and hinted at the antibacterial action of the coating. To explore the antibacterial mechanism of tungsten-doped TiO 2 coatings, Wang R. et al (2021) used MAO technology to coat the surface of Ti6Al4V with tungsten-doped TiO 2 with antibacterial properties. The microstructure of tungsten-doped and undoped TiO 2 coatings was studied and compared.…”
Section: Combined Application Of Mao and Other Treatment Methodsmentioning
Titanium and titanium alloy implants are essential for bone tissue regeneration engineering. The current trend is toward the manufacture of implants from materials that mimic the structure, composition and elasticity of bones. Titanium and titanium alloy implants, the most common materials for implants, can be used as a bone conduction material but cannot promote osteogenesis. In clinical practice, there is a high demand for implant surfaces that stimulate bone formation and accelerate bone binding, thus shortening the implantation-to-loading time and enhancing implantation success. To avoid stress shielding, the elastic modulus of porous titanium and titanium alloy implants must match that of bone. Micro-arc oxidation technology has been utilized to increase the surface activity and build a somewhat hard coating on porous titanium and titanium alloy implants. More recently, a growing number of researchers have combined micro-arc oxidation with hydrothermal, ultrasonic, and laser treatments, coatings that inhibit bacterial growth, and acid etching with sand blasting methods to improve bonding to bone. This paper summarizes the reaction at the interface between bone and implant material, the porous design principle of scaffold material, MAO technology and the combination of MAO with other technologies in the field of porous titanium and titanium alloys to encourage their application in the development of medical implants.
“…The intermetallic and oxide-based phases observed on all coating surfaces improve mechanical properties such as hardness and tribological properties. However, the outer layers of ESD and MAO coatings contain amorphous phases due to the rapid solidification nature under the atmosphere (for the ESD process) [24] and electrolyte conditions (for the MAO process) [25,26]. Thus, the outer layers of these coatings are insufficient to carry loads.…”
In this work, an aerospace-grade Ti6Al4V alloy was coated by electro spark deposition (ESD), micro-arc oxidation (MAO), and combined ESD + MAO coating methods to improve mechanical properties and wear resistance. The results obtained from the coatings were compared with the bare Ti6Al4V. The phase structure, surface-cross sectional morphologies, elemental distribution, surface-cross sectional mechanical and wear properties of the bare alloy and the coatings were investigated by XRD, SEM, EDX-mapping, nanoindentation, micro--Vickers hardness, and tribometer. The XRD results revealed that the MAO and ESD + MAO duplex coatings contained rutile-TiO2 and γ-Al2O3 phases, while Al3Ti, Al2Ti, and AlTi3 phases were observed in the ESD coating. The average hardness of all coatings was significantly improved with respect to bare Ti6Al4V due to the crystalline and dense structure of the inner layer. In addition, the wear resistance of the coatings was significantly improved compared to that of bare Ti6Al4V. K e y w o r d s : micro-arc oxidation (MAO), electro spark deposition (ESD), Al2O3/TiO2 composite, mechanical properties, tribological properties
“…In vitro evidence showed that cobalt-titanium dioxide and cobalt oxide (CoO or Co 3 O 4 )-titanium dioxide nanoscale heterojunctions can downregulate the expression of respiratory gene levels in bacteria and cause oxidative damage to bacterial surfaces [ 174 ]. In another study, Wang et al also found that the antibacterial efficacy of tungsten-incorporated titanium dioxide coatings (prepared by micro-arc oxidization) was related to their strong capability in the storage of bacteria-extruded electrons and accumulation of sufficient valence-band holes inducing oxidative damages to the microbes [ 175 ]. These findings have opened up new avenues for taking advantage of the intrinsic feature of biological systems to design and control the antibacterial actions of biomaterials.…”
Section: Innovative Designs To Mitigate Device-associated Infectionsmentioning
The uses of implantable medical devices are safer and more common since sterilization methods and techniques were established a century ago; however, device-associated infections (DAIs) are still frequent and becoming a leading complication as the number of medical device implantations keeps increasing. This urges the world to develop instructive prevention and treatment strategies for DAIs, boosting the studies on the design of antibacterial surfaces. Every year, studies associated with DAIs yield thousands of publications, which here are categorized into four groups, i.e., antibacterial surfaces with long-term efficacy, cell-selective capability, tailored responsiveness, and immune-instructive actions. These innovations are promising in advancing the solution to DAIs; whereas most of these are normally quite preliminary “proof of concept” studies lacking exact clinical scopes. To help identify the flaws of our current antibacterial designs, clinical features of DAIs are highlighted. These include unpredictable onset, site-specific incidence, and possibly involving multiple and resistant pathogenic strains. The key point we delivered is antibacterial designs should meet the specific requirements of the primary functions defined by the “intended use” of an implantable medical device. This review intends to help comprehend the complex relationship between the device, pathogens, and the host, and figure out future directions for improving the quality of antibacterial designs and promoting clinical translations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.