Bilatéralisation à distance d’une occlusion de la veine centrale de la rétine associée à un syndrome des anti-phospholipides primaire

Querques, Lea; Terrada, C; Souied, E.; Corrado, Addolorata; Cantatore, Francesco Paolo; Querques, Giuseppe

doi:10.1016/j.jfo.2011.08.014

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Традиционными системными факторами риска ретинальных сосудистых окклюзий являются: артериальная гипертензия, атеросклероз, сахарный диабет, гиперлипидемия, нарушения ритма сердца, сосудистый церебральный инсульт, повышенная вязкость крови [1]. В последние годы многие авторы отводят важную роль в развитии окклюзий сетчатки тромбофиличе-ским состояниям, к которым принадлежит антифосфолипидный синдром (АФС) [2][3][4][5]. АФСклинико-лабораторный симптомокомплекс, характеризующийся артериальными и/или венозными тромбозами любой локализации и невынашиванием беременности, в основе которых лежит гиперпродукция антифосфолипидных антител (аФЛ), приводящая к активации механизмов сосудистого повреждения и тромбообразования [6].…”

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“…Сосуды МЦР глаза являются такой же мишенью тромбообразования при АФС, как и сосуды любой другой локализации. АФС является редкой причиной вазоокклюзивной ретинопатии (от 0,2 до 8%, по данным большинства исследователей), но он ассоциируется с системностью сосудистого поражения, характеризуется неблагоприятным зрительным и жизненным прогнозом [2][3][4]. Роль АФС в развитии глазной сосудистой окклюзии возрастает у пациентов молодого возраста (менее 45 лет) в отсутствие традиционных сосудистых факторов риска.…”

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Electrophysiological studies of the retina in antiphospholipid syndrome

et al. 2017

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The use of different types of ERG enable detection of not only local, but also generalized retinal changes in APS. Regardless of the presence of retinal occlusion, APS patients show suppression of biopotential in most of cellular elements of the retina due to ischemia. Despite high visual acuity, the local macular potential gets significantly reduced in more than half of APS patients. Oscillatory potentials recording is a highly sensitive method for diagnosis of retinal ischmia in APS.

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Electrophysiological studies of the retina in antiphospholipid syndrome

et al. 2017

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Efficacité remarquable du rituximab dans une vascularite rétinienne occlusive bilatérale ayant révélé un SAPL secondaire au lupus

Charef,

Lemouaden,

Jeddou

et al. 2024

La Revue de Médecine Interne

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Ophthalmologic manifestations in primary antiphospholipid syndrome patients: A cross-sectional analysis of a primary antiphospholipid syndrome cohort (APS-Rio) and systematic review of the literature

Franco

Medina

Balbi

et al. 2020

Lupus

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Objective There is a broad spectrum of eye involvement in antiphospholipid syndrome (APS). The majority of descriptions are presented as case reports that include mostly APS patients secondary to systemic lupus erythematosus (SLE), with no compelling evidence in primary APS (PAPS). This study aimed to describe ocular manifestations in our well-defined PAPS cohort (APS-Rio) and then perform a systematic literature review (SLR) of ocular manifestations in patients with APS or positivity to aPL without SLE. Methods We retrospectively analyzed PAPS patients followed at our outpatient clinics. All patients fulfilled Sydney APS classification criteria (2006). We evaluated them for ocular symptoms and previous ocular diagnoses. Antiphospholipid antibodies and clinical APS manifestations were compared between patients with and without ocular manifestations. For the SLR, electronic databases were searched up to November 2019. Results We studied 105 PAPS patients; 90.5% were female and 56.2% were Caucasian. We found ocular manifestations in 37.1% of our cohort. Thrombosis was the main criteria manifestation (95.2%) and lupus anticoagulant was the most prevalent antibody. Ophthalmologic diagnoses were present in 7 patients, with 5 having retinal vessels thromboses. Amaurosis fugax was the leading complaint, present in 30 patients. In the univariate analysis, amaurosis fugax was related to livedo (p = 0.005), Raynaud’s phenomenon (p = 0.048) and the presence of anticardiolipin antibody (≥40 GPL/MPL) (p = 0.041). Hemianopia was associated with arterial hypertension (p = 0.049). In the multivariate analysis, the only association found was between livedo and amaurosis fugax (OR 4.09, 95%CI 1.5–11.11, p = 0.006). Our SLR incorporated 96 articles of ocular manifestations in patients with PAPS or positivity to aPL without SLE. Ocular findings varied from 5 to 88%, including anterior and posterior segments, orbital and neuro-ophthalmologic changes. Conclusion There is little evidence on ocular manifestations in PAPS. We described an association between livedo and amaurosis fugax. Prospective studies are needed to promote the best treatment and avoid blindness in PAPS patients.

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Bilatéralisation à distance d’une occlusion de la veine centrale de la rétine associée à un syndrome des anti-phospholipides primaire

Cited by 4 publications

References 11 publications

Electrophysiological studies of the retina in antiphospholipid syndrome

Electrophysiological studies of the retina in antiphospholipid syndrome

Efficacité remarquable du rituximab dans une vascularite rétinienne occlusive bilatérale ayant révélé un SAPL secondaire au lupus

Ophthalmologic manifestations in primary antiphospholipid syndrome patients: A cross-sectional analysis of a primary antiphospholipid syndrome cohort (APS-Rio) and systematic review of the literature

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