1972
DOI: 10.1002/1097-0142(197210)30:4<983::aid-cncr2820300419>3.0.co;2-3
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Bilateral Wilms' tumor.A review

Abstract: Three of five children with bilateral Wilms' tumor are alive and free of evidence of disease 21/2, 7, and 9 years from the time of their original diagnosis. One child (9‐year survival) had metastasis to five different anatomic sites. The prognosis for bilateral Wilms' tumor is guarded, but aggressive multimodal therapy may improve survival in these children.

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Cited by 45 publications
(4 citation statements)
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“…The incidence of bilateral adrenal neurobla toma is lower than that of Wilms's tumor (14) or retinoblastoma (9). We found 18 ca es of bilateral adrenal neuroblastoma including our own two cases between 1967 and 1992 in the English and Japanese literature (2-4, 6, 7, 10-13, 15, 16, 18).…”
Section: Discussionmentioning
confidence: 99%
“…The incidence of bilateral adrenal neurobla toma is lower than that of Wilms's tumor (14) or retinoblastoma (9). We found 18 ca es of bilateral adrenal neuroblastoma including our own two cases between 1967 and 1992 in the English and Japanese literature (2-4, 6, 7, 10-13, 15, 16, 18).…”
Section: Discussionmentioning
confidence: 99%
“…It remains stage dependent; however, anaplastic histology has recently been shown to have even greater unfavorable prognostic import [ 101 . Ragab et a1 [4] in 1972 reported that of 70 patients with bilateral Wilms tumor, 28 were considered cured (two-year survival rate of 40%). Recent data provide two-year survival rates in excess of 87% following surgery, combination chemotherapy, and irradiation [5] .…”
Section: Discussionmentioning
confidence: 99%
“…Its incidence in the United States is 7.8 cases per million population per year (ages 1 through 14) [2]. Bilateral Wilms tumor was first described by Rance in 1814 [3], and has been noted to account for 4-12% of all cases of Wilms tumor [4] . A recent review of 606 patients describes 33 (5.4%) who had bilateral Wilms tumor at presentation and an additional 20 (3.3%) who subsequently developed bilateral involvement [5] .…”
Section: Introductionmentioning
confidence: 99%
“…In general, treatment of bilateral Wilms' tu-mor must be highly individualized and, based on recent reviews, may be summarized as follows [6, 18, .47]: in all caes of Wilms' tumor, both kidneys should be thoroughly palpated or inspected. Originally, surgical attitudes favored gross total removal of tumor by nephrectomy, nephrectomy plus contralateral partial nephrectomy, or bilateral partial nephrectomy while sparing enough tissue ( 15%-35%) [41 ] to ensure adequate renal function. More recent publications [26] suggest that a more conservative surgical approach may be appropriate, stressing biopsy at initial exploration with subsequent second-and third-look operations and preservation of at least 60% of renal tissue.…”
Section: Treatmentmentioning
confidence: 99%