Bilateral Ventricular Hypertrophy in Rats Exposed to Acute or Chronic Hypobaric Hypoxia

Genovese, Arturo; Chiariello, Massimo; Latte, Salvatore; Alfieri, Walter De; Condorelli, M

doi:10.1159/000194560

Cited by 14 publications

(5 citation statements)

References 15 publications

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“…In addition, no difference in echocardiographic left ventricular mass was noted between N and CH rats during and after exposure. In previous studies, mammalian left ventricular mass was reported either increased (Genovese et al, 1983;Schneider et al, 1987), unaffected (Hultgren & Miller, 1967), or decreased (Scognamiglio et al, 1991) after chronic exposure to hypoxia. In our animal model, chronic exposure to mild hypoxia slowly increased posterior wall thickness and left ventricular cavity, but only in the first 3 weeks, which could not be therefore related to our HRV measurements made on day 72.…”

Section: Effects Of Cardiac Morphology and Functions On Hrv During Nomentioning

confidence: 91%

Heart Rate Variability in Rats Acclimatized to High Altitude

Melin

Fauchier

Dubuis³

et al. 2003

High Altitude Medicine & Biology

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The aims of this study were to relate heart morphology and functions changes to heart rate variability (HRV) components after acclimatization to high altitude and to define whether preadaptation to hypoxia could modulate HRV responses to acute hypoxic stress. Doppler-echocardiographic studies of the left ventricle were performed in female Wistar rats before, during, and after a 10-week exposure to moderate hypobaric hypoxia (CH rats, approximately 4000 m simulated) or normoxia (N rats, approximately 55 m). Right ventricular morphology and function and pulmonary artery pressure were evaluated using heart catheterization. Spectral analysis of HRV was studied after exposure in conscious unrestrained rats in normoxia and during acute hypoxic stress. Necropsy right ventricular hypertrophy and intraventricular and pulmonary artery hypertension were found in CH rats compared with N rats. Echocardiographic left ventricular morphology and functions were similar between the groups after exposures. Compared to the control group, CH rats had similar heart rates and HRV components when measured in normoxia. During acute hypoxic stress, HRV decreased in all rats, but less in CH rats. These results support the hypothesis that long-term mild hypoxia may moderate sympathetic activation induced by acute hypoxia and that right ventricular hypertrophy cannot be the direct cause of such a shift in sympathovagal nerve interaction during acute hypoxic stress.

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Section: Effects Of Cardiac Morphology and Functions On Hrv During Nomentioning

confidence: 91%

Heart Rate Variability in Rats Acclimatized to High Altitude

Melin

Fauchier

Dubuis³

et al. 2003

High Altitude Medicine & Biology

View full text Add to dashboard Cite

show abstract

“…Development of left ventricular hypertrophy during hypoxia [220] occurred independent of HT in carotid body-denervated [217] or sympatheticdenervated [218] rats, suggesting that the myocardial effect of hypoxia might be direct, not through increased BP levels. These data may confirm the clinical finding that left ventricular hypertrophy is often found in OSA patients, irrespective of the presence of HT, and cannot be completely explained as an effect of obesity [221].…”

Section: Systemic Arterial Pressure (Fig 6)mentioning

confidence: 92%

The cardiovascular effects of obstructive sleep apnoeas: analysis of pathogenic mechanisms

Mr¹,

Marrone²,

Insalaco³

et al. 1994

Eur Respir J

132

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“…Exposure of rats to an hypoxic atmosphere causes cardiac hypertrophy. Although it is the right ventricle that is primarily affected (because of the increase in pulmonary arterial pressure associated with pulmonary vasoconstriction), there is also hypertrophy of the left ventricle [21,22], possibly because of increased cardiac output and/or heart rate [23]. The recovery of cardiac kI to control values after 24 h of hypoxia (compared with the inhibition that we observed after 6 h of hypoxia [13]) may indicate that the protein-synthesis machinery is adapting to an increased pressure-volume workload.…”

Section: +1 +1mentioning

confidence: 99%

The effects of fasting or hypoxia on rates of protein synthesis in vivo in subcellular fractions of rat heart and gastrocnemius muscle

Preedy¹,

Sugden²

1989

Biochemical Journal

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We measured rates of protein synthesis in vivo in subcellular fractions (soluble, myofibrillar and stromal fractions) of the heart and the gastrocnemius from rats after fasting or under hypoxic conditions (i.e. atmospheres containing 5% or 10% O2). Such interventions are known to inhibit protein synthesis under some circumstances. The recovery of tissue protein after fractionation was 80-100%. The proportions of protein present in the soluble and stromal fractions were different in the two muscles. The rates of protein synthesis in the myofibrillar and stromal fractions were less than those for total mixed tissue protein, whereas the rate for soluble protein was greater. Both fasting and moderate hypoxia (10% O2 for 24 h) inhibited protein synthesis in the gastrocnemius. In this tissue, the synthesis of the myofibrillar fraction was apparently the most sensitive to inhibition, and this resulted in some significant increases in the soluble-fraction/myofibrillar-fraction protein-synthesis rate ratios. In the heart, fasting inhibited protein synthesis, but moderate hypoxia (10% O2 for 24 h) did not. The rate of protein synthesis in the cardiac myofibrillar fraction was again more sensitive to fasting than were the rates in the other fractions, but it was not as sensitive as that in the gastrocnemius. Under severely hypoxic conditions (5% O2 for 1 or 2 h), protein synthesis was decreased in all fractions in both tissues. These results suggest that the rates of protein synthesis in these relatively crude subcellular fractions vary.

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Bilateral Ventricular Hypertrophy in Rats Exposed to Acute or Chronic Hypobaric Hypoxia

Cited by 14 publications

References 15 publications

Heart Rate Variability in Rats Acclimatized to High Altitude

Heart Rate Variability in Rats Acclimatized to High Altitude

The cardiovascular effects of obstructive sleep apnoeas: analysis of pathogenic mechanisms

The effects of fasting or hypoxia on rates of protein synthesis in vivo in subcellular fractions of rat heart and gastrocnemius muscle

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