Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts

Conti, Catarine Lima; Nakamura-Palacios, Ester Miyuki

doi:10.1016/j.brs.2013.09.007

Cited by 75 publications

(39 citation statements)

References 22 publications

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“…Moreover, there was no effect after 5 sessions of active tES compared to sham. There was no significant effect on cocaine intake at 3-months follow-up, but found that 5 subjects in the active tES group and one for the sham group had remained abstinent (Conti and Nakamura-Palacios, 2014). …”

Section: Noninvasive Brain Stimulation In Psychostimulant Use Disordersmentioning

confidence: 95%

“…One study has assessed the effect of tES on cocaine-related cue reactivity (Conti et al, 2014). In this work, they measured event-related potentials cue-reactivity in abstinent crack-cocaine users.…”

Section: Noninvasive Brain Stimulation In Psychostimulant Use Disordersmentioning

confidence: 99%

“…They used the same stimulation parameters (20min, 2mA). The one reporting a decrease in craving applied anodal to the right DLPFC and cathodal to the left supraorbital area (Shahbabaie et al, 2014) whereas the one that did not applied anodal stimulation over the right DLPFC and cathodal over the left DLPFC (Conti et al, 2014). In regards to patients, the study reporting a decrease in craving used 1-week abstinent subjects whereas the other study required a minimum of 31-days of abstinence.…”

Section: Noninvasive Brain Stimulation In Psychostimulant Use Disordersmentioning

confidence: 99%

See 2 more Smart Citations

Noninvasive brain stimulation to suppress craving in substance use disorders: Review of human evidence and methodological considerations for future work

Hone‐Blanchet

Ciraulo

Pascual‐Leone

et al. 2015

Neuroscience & Biobehavioral Reviews

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Substance use disorders (SUDs) can be viewed as a pathology of neuroadaptation. The pharmacological overstimulation of neural mechanisms of reward, motivated learning and memory leads to drug-seeking behavior. A critical characteristic of SUDs is the appearance of craving, the motivated desire and urge to use, which is a main focus of current pharmacological and behavioral therapies. Recent proof-of-concept studies have tested the effects of non-invasive brain stimulation on craving. Although its mechanisms of action are not fully understood, this approach shows interesting potential in tuning down craving and possibly consumption of diverse substances. This article reviews available results on the use of repetitive transcranial magnetic stimulation (rTMS) and transcranial electrical stimulation (tES) in SUDs, specifically tobacco, alcohol and psychostimulant use disorders. We discuss several important factors that need to be addressed in future works to improve clinical assessment and effects of non-invasive brain stimulation in SUDs. Factors discussed include brain stimulation devices and parameters, study designs, brain states and subjects’ characteristics.

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Section: Noninvasive Brain Stimulation In Psychostimulant Use Disordersmentioning

confidence: 95%

Section: Noninvasive Brain Stimulation In Psychostimulant Use Disordersmentioning

confidence: 99%

Section: Noninvasive Brain Stimulation In Psychostimulant Use Disordersmentioning

confidence: 99%

See 1 more Smart Citation

Noninvasive brain stimulation to suppress craving in substance use disorders: Review of human evidence and methodological considerations for future work

Hone‐Blanchet

Ciraulo

Pascual‐Leone

et al. 2015

Neuroscience & Biobehavioral Reviews

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“…Also, more recently, small-scale investigational studies involving non-invasive neurostimulation such as tDCS and TMS seem to show some promise for the management of addictions (17 studies, medium effect size). Magnetic stimulation that targets the prefrontal cortex may increase cognitive control mechanisms, decrease craving levels, or both [25,26]. However, it must be kept in mind that right now, most of these interventions are in the early stages of research and development, and may or may not turn out to be effective approaches towards moral enhancement in the long run.…”

Section: How To Attain Moral Enhancement?mentioning

confidence: 99%

Moral Enhancement: Do Means Matter Morally?

Focquaert

Schermer²

2015

Neuroethics

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One of the reasons why moral enhancement may be controversial, is because the advantages of moral enhancement may fall upon society rather than on those who are enhanced. If directed at individuals with certain counter-moral traits it may have direct societal benefits by lowering immoral behavior and increasing public safety, but it is not directly clear if this also benefits the individual in question. In this paper, we will discuss what we consider to be moral enhancement, how different means may be used to achieve it and whether the means we employ to reach moral enhancement matter morally. Are certain means to achieve moral enhancement wrong in themselves? Are certain means to achieve moral enhancement better than others, and if so, why? More specifically, we will investigate whether the difference between direct and indirect moral enhancement matters morally. Is it the case that indirect means are morally preferable to direct means of moral enhancement and can we indeed pinpoint relevant intrinsic, moral differences between both? We argue that the distinction between direct and indirect means is indeed morally relevant, but only insofar as it tracks an underlying distinction between active and passive interventions. Although passive interventions can be ethical provided specific safeguards are put in place, these interventions exhibit a greater potential to compromise autonomy and disrupt identity.

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“…The potential effects of tDCS in cocaine addiction remain poorly explored (Conti and Nakamura-Palacios, 2014). However, reduced cocaine craving has been reported after another kind of non-invasive cortical stimulation, repeated transcranial magnetic stimulation (rTMS) (Camprodon et al, 2007; Politi et al, 2008), suggesting that modifying cortical activity may also alter psychostimulant-induced processes.…”

Section: Introductionmentioning

confidence: 99%

Transcranial direct current stimulation produces long-lasting attenuation of cocaine-induced behavioral responses and gene regulation in corticostriatal circuits

et al. 2016

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Transcranial direct current stimulation (tDCS) is a non-invasive method to modulate cortical excitability. This technique is a promising emerging tool to treat several neuropathologies, including addiction. We have previously shown in mice that repeated tDCS normalizes pathological behaviors associated with chronic nicotine exposure. Here, we evaluated, in adult female mice, the impact of tDCS on cocaine-induced behavior and gene regulation in corticostriatal circuits implicated in psychostimulant addiction. Anodal tDCS was applied transcranially over the frontal cortex. Three weeks after repeated tDCS, we investigated the induction of a gene expression marker (Zif268) by cocaine (25 mg/kg) in 26 cortical and 23 striatal regions using in situ hybridization histochemistry. We also assessed place preference conditioning by cocaine (5, 10, and 25 mg/kg). tDCS pretreatment increased basal expression and attenuated cocaine (25 mg/kg)-induced expression of Zif268 in specific corticostriatal circuits. Cocaine-induced locomotor activation (25 mg/kg) and place preference conditioning (5 and 25 mg/kg) were also reduced. These results demonstrate that tDCS can attenuate molecular and behavioral responses to cocaine for several weeks. Together, our findings provide pre-clinical evidence that such electrical brain stimulation may be useful to modify the psychostimulant addiction risk.

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Bilateral Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex Changes the Drug-cued Reactivity in the Anterior Cingulate Cortex of Crack-cocaine Addicts

Cited by 75 publications

References 22 publications

Noninvasive brain stimulation to suppress craving in substance use disorders: Review of human evidence and methodological considerations for future work

Noninvasive brain stimulation to suppress craving in substance use disorders: Review of human evidence and methodological considerations for future work

Moral Enhancement: Do Means Matter Morally?

Transcranial direct current stimulation produces long-lasting attenuation of cocaine-induced behavioral responses and gene regulation in corticostriatal circuits

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