Bilateral Thoracic Endometriosis Affecting the Lung and Diaphragm

Nezhat, Camran; King, Louise P.; Paka, Chandhana; Odegaard, Justin I.; Beygui, Ramin E.

doi:10.4293/108680812x13291597716384

Cited by 33 publications

(21 citation statements)

References 12 publications

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“…Other organs may also be affected, such as the liver, bowels, adrenal glands, lungs, kidneys, and brain. [4][5][6][7][8][9][10][11] Cases of endometriosis have been described in the surgical scar, cesarean section scar, episiotomy scar after vaginal delivery, or following procedures where there was contact with endometrial tissue, such as hysterotomy performed in the first midterm of pregnancy, hysterectomy, ectopic pregnancy and tubal ligation. 2,12,13 In these patients, the rate of occurrence of pelvic endometriosis is similar to that of other women, and is not regarded as a risk factor for the disease.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Cases of Abdominal Wall Endometriosis at Universidade Estadual de Campinas in a period of 10 Years

Yela

Trigo

Benetti‐Pinto

2017

Rev Bras Ginecol Obstet

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Keywords► abdominal wall endometriosis ► pelvic pain ► recurrence ► cesarean section scar AbstractPurpose To determine the clinical and epidemiological characteristics of abdominal wall endometriosis (AWE), as well as the rate and recurrence factors for the disease. Methods A retrospective study of 52 women with AWE was performed at Universidade Estadual de Campinas from 2004 to 2014. Of the 231 surgeries performed for the diagnosis of endometriosis, 52 women were found to have abdominal wall endometriosis (AWE). The frequencies, means and standard deviations of the clinical characteristics of these women were calculated, as well as the recurrence rate of AWE. To determine the risk factors for disease recurrence, Fisher's exact test was used. Results The mean age of the patients was 30.71 AE 5.91 years. The main clinical manifestations were pain (98%) and sensation of a mass (36.5%). We observed that 94% of these women had undergone at least 1 cesarean section, and 73% had used medication for the postoperative control of endometriosis. The lesion was most commonly located in the cesarean section scar (65%). The recurrence rate of the disease was of 26.9%. All 14 women who had relapsed had surgical margins compromised in the previous surgery. There was no correlation between recurrent AWE and a previous cesarean section (p ¼ 0.18), previous laparotomy (p ¼ 0.11), previous laparoscopy (p ¼ 0.12) and postoperative hormone therapy (p ¼ 0.51). Conclusion Women with previous cesarean sections with local pain or lumps should be investigated for AWE. The recurrence of AWE is high, especially when the first surgery is not appropriate and leaves compromised surgical margins. ResumoObjetivos Determinar as características clínicas e epidemiológicas da endometriose de parede, bem como sua taxa de recorrência e os fatores que levam a ela. Métodos Estudo retrospectivo, em que se avaliaram 52 mulheres com endometriose de parede na Universidade Estadual de Campinas no período de 2004 a 2014. Entre as

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Section: Introductionmentioning

confidence: 99%

Evaluation of Cases of Abdominal Wall Endometriosis at Universidade Estadual de Campinas in a period of 10 Years

Yela

Trigo

Benetti‐Pinto

2017

Rev Bras Ginecol Obstet

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“…Histological examination is considered to be the golden standard; however, it is very difficult to perform. A definite histological examination can be conducted only in one-third of the cases [39,40].…”

Section: Discussionmentioning

confidence: 99%

Thoracic Endometriosis presented as catamental hemoptysis: Fourteen Cases of a Rare Disease and the hormonal treatment management

Dai

Liu

et al. 2020

Preprint

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Background: Thoracic endometriosis syndrome (TES) is a rare disease in which a functioning endometrial tissue is observed in the pleura, lung parenchyma, airways, or diaphragm. The optimal management of this disease remains a matter of debate Methods: Retrospective study in one university based tertiary care hospital between 1997 to 2017. 14 women presented as CH diagnosed with thoracic endometriosis were included. The main outcome of measure was cessation or recurrence of the clinical manifestations of thoracic endometriosis. Baseline parameters were presented using descriptive statistics. For categorical variables, Pearson’s chi-square tests or Fisher’s exact tests was used as appropriate to describe the characteristic of thoracic endometriosis presented as CH, and the long-term prognosis after hormonal treatment. Results : The mean onset age of the 14 patients was 30.21±5.40 years. Catamenial hemoptysis (CH) was characteristic symptom of these patients, and most of patients (13/14, 92.9%) had regular menstruation and only 42.9% (6/14) of the patients complained of different degrees of dysmenorrhea. All patients underwent chest computed tomography (CT) scan during menstruation and 2 or 3 weeks after menstruation, which showed the obvious shrinking or disappearance of the lesions. No active bleeding on bronchial mucosa were observed in patients with CH, and the bronchoalveolar lavage (BAL) did not find the typical abnormality. All of patients were given GnRH-a for 3 to 6 months, eleven of them were administered with COCs cyclically after GnRH-a. All patients were followed up and the median follow-up duration was 24 months. Hemoptysis recurrence was observed in one patient. Conclusion: CH is a rare clinical entity of thoracic endometriosis, which has the typical cyclic manifestation with menstruation. The change of CT images during and after menstruation or the response to GnRHa were helpful for accurate diagnosis. Hormonal treatment with GnRH-a followed by COCs cyclically could be employed as a choice of therapy for efficient management of thoracic endometriosis.

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“…In humans, previous work in our laboratory showing the ability of bone marrow-derived stem cells to contribute to endometriotic lesions and differentiate to stromal and epithelial phenotypes may provide further evidence for a novel theory of the origin of distal endometriosis and rare cases of endometriosis in men. 35,[57][58][59][60] Endometriotic lesions have been found in areas in which retrograde menstruation is unlikely to reach, such as the brain, lung, and nose as the sole cause of endometriosis. [58][59][60][61] These cases also dispute the transition of peritoneal cells to an endometrial phenotype as the etiology of endometriosis, as these lesions are not in the peritoneum.…”

Section: The Role Of Stem Cells In Endometriosismentioning

confidence: 99%

The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis

et al. 2015

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Human endometrium is a dynamic organ that normally undergoes repetitive cyclic regeneration. To enable this rapid regeneration, it is not surprising that the endometrium contains a reservoir of progenitor stem cells. However, this pool of cells that allows the growth of the endometrium also allows for unrestrained growth that can reach beyond the endometrium. In this review, we will address the role of stem cells in endometriosis. Recent characterization of stem cell populations within human endometrium has opened the possibility of understanding their physiologic as well as their pathologic roles. While stem cells are critical to the cyclic regeneration of a healthy endometrium, we have shown that both endometrium-derived and bone marrow-derived stem cells can migrate to ectopic sites and contribute to the development of endometriosis. Furthermore, endometriosis interferes with the normal stem cell trafficking to the uterus that is necessary for endometrial growth and repair. Altered stem cell mobility and engraftment characterize this disease.

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Bilateral Thoracic Endometriosis Affecting the Lung and Diaphragm

Abstract: A multidisciplinary approach with video-assisted thoracoscopic surgery and laparoscopy was used to manage a very rare case of bilateral catamenial pneumothoraces and pelvic endometriosis.

Cited by 33 publications

References 12 publications

Evaluation of Cases of Abdominal Wall Endometriosis at Universidade Estadual de Campinas in a period of 10 Years

Evaluation of Cases of Abdominal Wall Endometriosis at Universidade Estadual de Campinas in a period of 10 Years

Thoracic Endometriosis presented as catamental hemoptysis: Fourteen Cases of a Rare Disease and the hormonal treatment management

The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis

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