Bilateral testicular tumors: A report of nine cases with long‐term follow‐up

Οhyama, Chikara; Kyan, Atsushi; Satoh, Makoto; Saitoh, Sei–Ichi; Nishimura, Yuichi; Imai, Yoshihiro; Oikawa, Katsuhiko; Yokoyama, Jun; Suzuki, Kenichi; Takeuchi, Mieko; Hoshi, Senji; Orikasa, Seiichi

doi:10.1046/j.1442-2042.2002.00446.x

Cited by 18 publications

(16 citation statements)

References 13 publications

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“…It is well known that having a TGCT is the major risk factor for developing a second TGCT in the contralateral testis with the second tumour occurring in 1 -5% of patients (Bokemeyer et al, 1993;Dieckmann et al, 1993Dieckmann et al, , 1999Dieckmann et al, 2002Heidenreich et al, 1995Heidenreich et al, , 1997Heidenreich et al, , 2000Gerl et al, 1997;Tekin et al, 2000;Geczi et al, 2001;Ondrus et al, 2001;Che et al, 2002;Ohyama et al, 2002). The first published series by Gilbert and Hamilton (1942) included 1466 consecutive patients and found an incidence of 1.6%.…”

Section: Discussionmentioning

confidence: 99%

“…Several risk factors for developing a TGCT have been identified, uppermost among which is a previous TGCT (Osterlind et al, 1991). The incidence of bilateral testicular germ-cell tumour (BGCT) ranges between 1 and 5% in previously published large series (Bokemeyer et al, 1993;Dieckmann et al, 1993Dieckmann et al, , 1999Dieckmann et al, , 2002Heidenreich et al, 1995Heidenreich et al, , 1997Heidenreich et al, , 2000Gerl et al, 1997;Tekin et al, 2000;Geczi et al, 2001;Ondrus et al, 2001;Che et al, 2002;Ohyama et al, 2002). The charts of 2383 consecutive patients treated at the Institut Gustave Roussy over a 22-year period were analysed to estimate the incidence of BGCT, to identify potential risk factors and to evaluate the long-term survival of patients with BGCT.…”

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Bilateral germ-cell tumours: 22-year experience at the Institut Gustave Roussy

et al. 2004

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The aim of this study was to describe the incidence, clinical and histological characteristics, treatment and long-term follow-up of bilateral germ-cell tumours (BGCT) of the testis in order to determine in what respects they differ significantly from unilateral germcell tumours. In all, 31 patients with BGCT had metachronous tumours and 14 had synchronous tumours. Among the metachronous tumours, 61% occurred more than 5 years after the first tumour. The overall incidence of BGCT in patients with testicular germ-cell tumours (TGCT) was 1.9%. The incidence was 3.2% in patients presenting with a seminoma and 1.4 % in patients presenting with a nonseminomatous germ-cell tumour (NSGCT). Patients under 30 years of age at the time of the initial diagnosis had a higher incidence of bilateral tumours compared with older men. The outcome of BGCT was excellent. A high association was found between BGCT, sterility and suspected genetic risk factors for TGCT. These results argue against a systematic contralateral biopsy at diagnosis of first TGCT in all patients, but emphasise the importance of patient education and of the need to better identify patients at risk for a second TGCT. Therapeutic indications for synchronous BGCT, including conservative treatment, need to be better defined. Testicular germ-cell tumour (TGCT) is a rare disease with an estimated incidence of five out of 100 000. An increase of more than 50% has been demonstrated in all Western countries during the last decades (Grenlee et al, 2001). Several risk factors for developing a TGCT have been identified, uppermost among which is a previous TGCT (Osterlind et al, 1991). The incidence of bilateral testicular germ-cell tumour (BGCT) ranges between 1 and 5% in previously published large series (Bokemeyer et al, 1993;Dieckmann et al, 1993Dieckmann et al, , 1999Dieckmann et al, , 2002Heidenreich et al, 1995Heidenreich et al, , 1997Heidenreich et al, , 2000Gerl et al, 1997;Tekin et al, 2000;Geczi et al, 2001;Ondrus et al, 2001;Che et al, 2002;Ohyama et al, 2002). The charts of 2383 consecutive patients treated at the Institut Gustave Roussy over a 22-year period were analysed to estimate the incidence of BGCT, to identify potential risk factors and to evaluate the long-term survival of patients with BGCT. PATIENTS AND METHODSBetween 1979 and 2002, 2383 patients with TGCT were treated in the Adult Cancer Department at the Institut Gustave Roussy (IGR). The list of patients was obtained from a computerised database. Among these 2383 patients, 45 had a BGCT. The medical records of these 45 patients were reviewed to collect the following information: previous personal and family medical history, clinical characteristics at presentation, histopathology, treatment, interval between the development of the two tumours and follow-up.All available pathology slides were reviewed. Most patients had their orchidectomy at other institutions. Haematoxylin-and eosinstained slides of both testicular tumours were available for 36 patients, and slides of only one tumour were avai...

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Bilateral germ-cell tumours: 22-year experience at the Institut Gustave Roussy

et al. 2004

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“…Seventy (46%) are lymphomas, 10 (6%) are sex-cord/stromal [15][16][17][18] The oldest patient we have found in the literature was a remarkable case of pure embryonal carcinoma in a man of 96. 16 Spontaneous regression, 19 necrosis, 20 presentation as metastasis 21,22 and bilateral tumours 23 have all been reported in elderly men with seminoma. One report of two cases outlines problems in treating elderly men with seminomas.…”

Section: Discussionmentioning

confidence: 99%

Malignant germ cell tumours in the elderly: a histopathological review of 50 cases in men aged 60 years or over

et al. 2008

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Malignant testicular germ cell tumours in the elderly are extremely rare with anecdotal accounts of their aggressive behaviour. Fifty cases of germ cell tumour, diagnosed at the age of 60 years or above, were pathologically reviewed. The oldest patient was 86 years of age, with 78% of cases presenting in men in their 60s. Forty-one (82%) of the tumours were seminomas with only nine cases (18%) of mixed or nonseminomatous germ cell tumour. However, all non-seminomatous types of tumour were represented in the series. The macroscopic tumour size was significantly larger (median ¼ 6 cm, range ¼ 2-11 cm) than comparable series in younger men. They were also of higher stage with more frequent vascular invasion and rete testis invasion than is typically seen in a younger population. The tumours were less associated with intratubular germ cell neoplasia than in younger men as it was present in only 47% of assessable cases. We conclude that germ cell tumours, in man aged 60 years or above, present at a later stage than in younger men, and although most are seminomas, non-seminomatous tumours may occur with a wide spectrum of morphology.

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“…It is also known that previous TGCT is the main factor for developing contralateral germ cell testicular tumour, with a relative risk of 500 to 1000 [4]. Second tumours are usually metachronous, but synchronous tumours have also been reported [5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Bilateral testicular germ cell tumours (BTGCTs) account for about 2-3% of testicular malignancies [9].…”

Section: Introductionmentioning

confidence: 99%