Bilateral Testicular Germ Cell Tumors in Turkey: Increase in Incidence in Last Decade and Evaluation of Risk Factors in 30 Patients

Abstract

The risk of contralateral testicular germ cell tumor in patients with seminoma was 2 times higher than in those without a history of tumor. Synchronous tumors present at advanced stage and have similar histology on each side. Clinical outcome is excellent with appropriate treatment. Contralateral testis biopsy at initial diagnosis is not mandatory.

Bilateral testicular germ cell tumours: a single hospital experience

“…As has been mentioned, the main risk factors for contralateral testicular tumour are history of unilateral tumour, cryptorchidism and positive familial history [3][4][5][6]. The risk of developing a contralateral testicular tumour is 500 times greater than in healthy male subjects [4].…”

“…Incidence has increased in the last three decades, and different risk factors such as family history and cryptorchidism have been identifi ed [3][4][5][6]. It is also known that previous TGCT is the main factor for developing contralateral germ cell testicular tumour, with a relative risk of 500 to 1000 [4].…”

“…It is also known that previous TGCT is the main factor for developing contralateral germ cell testicular tumour, with a relative risk of 500 to 1000 [4]. Second tumours are usually metachronous, but synchronous tumours have also been reported [5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Bilateral testicular germ cell tumours (BTGCTs) account for about 2-3% of testicular malignancies [9].…”

Seminoma testicular bilateral sincrónico en un paciente adulto con criptorquidia bilateral: reporte de un caso y revisión de la literatura

“…B: Nótese la presencia de masa al nivel de la cavidad pélvica. A B mixtos, tumor del saco vitelino y carcinomas embrionarios (puros o combinados) [3][4][5] .…”

“…Existen dos estudios donde se analizan 7 y 6 casos clíni-cos y se cree que los tumores bilaterales sincrónicos pueden presentarse en estadios elevados, aunque debido al reducido número de pacientes incluidos en este estudio los resultados no pueden ser del todo concluyentes 3,4,7 .…”