Bilateral testicular adrenal rests in a boy with congenital adrenal hyperplasia

Kim, Hee Kyung; Crotty, Eric J.

doi:10.1007/s00247-010-1851-z

Cited by 7 publications

(4 citation statements)

References 2 publications

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“…2 The adrenal rests can impart mass effect on normal surrounding testicular tissue, conferring an increased risk for gonadal dysfunction and infertility. 3 Thus, yearly ultrasonographic evaluation is recommended for boys and men with CAH. 4 Ultrasonographic evaluation of the testicular adrenal rests is variable.…”

Section: Discussionmentioning

confidence: 99%

Testicular Adrenal Rests in Congenital Adrenal Hyperplasia

Yannes

Tublin²

2016

Ultrasound Quarterly

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Section: Discussionmentioning

confidence: 99%

Testicular Adrenal Rests in Congenital Adrenal Hyperplasia

Yannes

Tublin²

2016

Ultrasound Quarterly

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“…It is assumed that poor hormonal control is an important factor in the pathogenesis of TART ( 1 , 11 , 21 , 27 ). However, TART is also found in patients that were adequately treated.…”

Section: Discussionmentioning

confidence: 99%

Testicular Adrenal Rests Tumors and Testicular Microlithiasis in a Brazilian Case Series with Classic Congenital Adrenal Hyperplasia

Carvalho

Lora

Penna

et al. 2016

Int J Endocrinol Metab

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BackgroundTesticular adrenal rest tumors are a benign condition characterized by the presence of remnants of adrenal tissue within the testes that can lead to infertility. Testicular microlithiasis are calculus deposits within the seminiferous tubules. Both are described in congenital adrenal hyperplasia.ObjectivesDescribe the frequency of testicular adrenal rest tumors and testicular microlithiasis in a Brazilian case series of patients with classic congenital adrenal hyperplasia and to also relate these changes to disease control and hypothalamic-pituitary-gonadal axis disorders.MethodsCase series study. An ultrasound examination of the scrotum was performed on 12 patients between the ages of 5.33 to 22 (14.72 ± 5.26) years. Testicular adrenal rest tumors were classified according to the degree of testicular infiltration in stages by adapting the Grinten’s classification, ranging from the absence of testicular adrenal rests visible by ultrasound (stage ≤ 1) to chronic obstruction of the testicular parenchyma with irreversible damage of the testicle (stage 5).ResultsSix patients (5 salt wasting and 1 simple virilizing) with an average age of 17.27 ± 3.09 years and have gone through puberty showed testicular adrenal rest tumors (Grinten stage ≥ 3). In 2 of the patients there was a coincidence with testicular microlithiasis. The frequency of testicular adrenal rest tumors did not relate with the levels of serum 17-hydroxyprogesterone and androstenedione. In 3 patients with testicular adrenal rest tumors, gonadotropin levels were suggestive of hypergonadotropic hypogonadism and one of hypogonadotropic hypogonadism.ConclusionsTesticular adrenal rest tumors were found in greater frequency during puberty and was not related to hormonal control in this group. Some of them happened with testicular microlithiasis.

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“…However, TARTs may also be found in patients who were adequately treated, as was demonstrated in a recent case series [6]. Additionally, further studies have shown that some patients with poorly controlled CAH will never develop TARTs [13,14]. This implies that inadequate hormonal control and medication non-compliance may be part of a continuum of factors in the development of TARTs.…”

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confidence: 85%