Bilateral temporal bone xanthoma

Muthusamy, Karthikeyan; Azmi, Khairul; Prepageran, Narayanan; Rajagopalan, Raman; Rahman, Nazarina Abdul; Waran, Vicknes

doi:10.3171/jns/2008/108/2/0361

Cited by 26 publications

(38 citation statements)

References 7 publications

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“…The lesion is almost always solitary and occurs most frequently in the hand and flat bones [7,[9][10][11]. In the English language literature, seventeen cases have been reported affecting the temporal bone [2]. Xanthomas of the gnathic bones are hard to quantify as some reports describe xanthomatous lesions without a clear histologic description; however it appears that less than ten cases of primary intraosseous xanthoma of the mandible are reported [3-5, 8, 12].…”

Section: Discussionmentioning

confidence: 99%

“…Computed tomogram shows loss of normal trabecular pattern in the medullary cavity, and the lesion may have a higher density than the normal bone marrow [14]. Magnetic resonance imaging has been used and shows mixed hypointensityhyperintensity on both T1 and T2 weighted MRI [2,13]. Histopathologically, histiocytes and lipid-containing macrophages, or foam cells, are present exhibiting a faintly granular cytoplasm, occasional multinucleated giant cells, and fibrous connective tissue.…”

Section: Discussionmentioning

confidence: 99%

“…Lipids accumulate within macrophages, causing what are histologically noted as foam cells, and extracellular cholesterol crystallizes into clefts. The cholesterol clefts induce an inflammatory giant cell reaction causing fibrosis [2]. Dahlin [23] proposed that the lesion is secondary to a pre-existing process such as fibrous dysplasia, aneurysmal bone cyst, idiopathic bone cavity, giant cell tumors, or brown tumor of hyperparathyroidism.…”

Section: Discussionmentioning

confidence: 99%

“…Xanthomas are benign lesions of soft tissue commonly seen in skin or over subcutaneous tissue of tendon sheaths and extensor surfaces after minor trauma or friction [1,2]. Xanthoma formation occurs most frequently in patients with endocrine and metabolic diseases [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…Xanthoma formation occurs most frequently in patients with endocrine and metabolic diseases [1][2][3][4]. Xanthoma is derived from the Greek xanthós, which means yellow, and is related to the altered metabolism of lipids and the accumulation of yellow pigment in skin and other internal organs [3].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Primary Xanthoma of the Mandible: Report of a Rare Case

Morel

Kelsch

Nolan

2015

Head and Neck Pathol

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Xanthoma is a lesion most commonly seen in soft tissues such as the skin, subcutis, or tendon sheaths. Xanthoma formation is often associated with primary or secondary hyperlipidemia. Primary bone xanthomas are extremely rare benign bone lesions not associated with hyperlipidemia, histopathologically characterized by histiocytes, abundant lipid containing macrophages (foam cells), and multinucleated giant cells. Cholesterol clefts can be found in the medullary bone. Less than ten cases of xanthoma in the mandible have been reported. We present a rare primary intrabony xanthoma in a normolipidemic patient.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Primary Xanthoma of the Mandible: Report of a Rare Case

Morel

Kelsch

Nolan

2015

Head and Neck Pathol

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A rare case of primary bone xanthoma of the clivus

et al. 2012

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Primary bone xanthoma is a rare type of tumor, and those developing primarily within the skull are even more unusual. In this case, a primary bone xanthoma of the clivus without endocrine or metabolic complications represents the first of this type to be reported. The patient, a 24-year-old woman, initially experienced frequent headaches. Subsequent skull tomography and bone-window computed tomography (CT) revealed a clearly demarcated osteolytic lesion in the clivus. T1-weighted magnetic resonance imaging (MRI) exhibited low intensity, and T2-weighted MRI showed iso-high intensity and a heterogeneously faint contrast effect. The tumor was completely resected, after which the patient's headaches disappeared completely. Because xanthoma is devoid of neoplastic features, it does not necessarily require aggressive therapy. Therefore, it is very important to understand the characteristics of its clinical symptoms and to give due consideration to differential diagnosis based on pathological presentations and imaging features. This study introduces information regarding a bone xanthoma originating within the skull, together with a review of bone xanthoma literature.

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Endoscopic endonasal resection of clival xanthoma: case report and literature review

González-García¹,

Asenjo-García²,

Bautista-Ojeda³

et al. 2015

Neurosurg Rev

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Bone xanthoma is an extremely rare and benign tumor in terms of its nature and growth over time. We describe the first case coexisting with ventriculomegaly secondary to aqueduct stenosis (non-tumoral hydrocephalus), the second xanthoma of the clivus described to date. The patient was a 51-year-old woman with headaches and absence seizures. Axial T1-weighted MRI showed a well-demarcated, hypointense, osteolytic, 25 × 18 × 15 mm lesion with cortical erosion located at the right margin of the clivus. Sagittal T2-weighted MRI demonstrated a hypointense mass without associated edema. Sagittal gadolinium-enhanced T1-weighted MRI showed contrast uptake with a partially hypointense rim. The increased ventricular size without periventricular edema was associated with aqueduct stenosis, and there was no contiguity with the tumor. A neuronavigation image-guided transsphenoidal approach was chosen to perform a macroscopically complete resection. Intraoperative histopathological study showed a chordoma of the clivus. Exhaustive postsurgical study revealed the benign nature of a bone xanthoma. Given the finding of a clival lesion, the differential diagnosis is essentially with other malignant entities with a rapidly fatal outcome, such as metastases, or with a possible invasive evolution, such as clivus chordomas. This report describes the clinical, radiological, and pathological keys for such differentiation in order to avoid unnecessarily aggressive treatment with ablative surgery and radiotherapy.

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Bilateral temporal bone xanthoma

Cited by 26 publications

References 7 publications

Primary Xanthoma of the Mandible: Report of a Rare Case

Primary Xanthoma of the Mandible: Report of a Rare Case

A rare case of primary bone xanthoma of the clivus

Endoscopic endonasal resection of clival xanthoma: case report and literature review

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