Bilateral Syringomatous Adenomas of the Nipple

Montgomery, Nathan D.; Bianchi, Gregory D.; Klauber-DeMore, Nancy; Budwit, Debra

doi:10.1309/ajcpfjuztll0vgnx

Cited by 13 publications

(7 citation statements)

References 6 publications

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“…P63 is also positive in myoepithelial cells and the nuclei of epithelial cells with squamoid differentiation (Figure 2) [4,11].…”

Section: Issn:2472-4971mentioning

confidence: 95%

“…On mammography ISA predominantly presents as a dense, spiculated mass in the sub-areolar region, however may appear as a poorly defined mass with distal acoustic shadowing [4]. Previous case reports demonstrate a large array of changes on ultrasound examination and in many cases no abnormality is detected.…”

Section: Issn:2472-4971mentioning

confidence: 96%

“…In one of the largest case series to date, 7 of 11 cases had initially been incorrectly diagnosed as tubular carcinoma [3]. There are no radiological features classical of ISA and it is not possible to differentiate from carcinoma upon ultrasound or mammography [4].…”

Section: Issn:2472-4971mentioning

confidence: 99%

“…It is well documented that fine needle aspiration (FNA) and core biopsy have a limited role in the diagnosis of ISA [4]. Macroscopically they are usually ill-defined, irregular masses with a grey/tan cut surface.…”

Section: Issn:2472-4971mentioning

confidence: 99%

“…Symptoms can be present from months to years [6]. One case report describes ISA presenting as a fungating tumour in an elderly woman who had noticed the changes for several years but refrained from seeking medical attention [4]. …”

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confidence: 99%

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Infiltrating Syringomatous Adenoma of the Nipple: A Case Report

Buckthought¹,

Gandhi²,

Popadich³

et al. 2017

J Med Surg Pathol

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We describe a case of a 46-year-old woman who was treated initially for a presumed non-lactational breast abscess.As symptoms did not subside with conservative management a major duct excision was conducted and histology revealed an infiltrating syringomatous adenoma.She underwent further surgery to achieve clear margins and the tumour is the largest reported to date.These are benign, infiltrating lesions and are rare with less than 40 cases reported in the literature.Patients usually present with a retro-areolar mass and adjacent skin and nipple changes. Radiologically they are difficult to differentiate from breast cancer and diagnosis is largely confirmed through histologic and immunohistochemical analysis.Treatment is with local excision to achieve clear margins as recurrence rates are high with residual tumour. Keywords: Syringomatous adenoma; Nipple; Breast abscess Case Report:Mrs A, a 46-year-old woman was initially admitted acutely to hospital with a presumed non-lactational breast abscess in the central left breast and commenced on intravenous antibiotics.She had been assessed nine years previously by a breast surgeon for left nipple discomfort that was thought to be due to duct ectasia. She was offered a duct excision at this time but declined. She underwent needle aspiration and purulent appearing material was obtained however laboratory analysis did not identify causative bacteria. She experienced clinical improvement and was discharged home.At subsequent outpatient clinic follow up the area of induration around the left nipple remained along with a small sub-areolar collection on ultrasound, which persisted despite antibiotics and serial aspiration.Ultrasound did not suggest features concerning for malignancy. As the nipple changes failed to settle the patient was offered left major duct excision. Histology demonstrated appearances suggestive of infiltrating syringomatous adenoma (ISA) of the nipple.The lesion was 45 × 25 mm, which appears to be the largest case of ISA reported in the literature. As margins were positive, the decision was made for re-excision with complete excision of the left nipple areola complex. Histology confirmed that the residual ISA had been excised with negative margins.

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“…P63 is also positive in myoepithelial cells and the nuclei of epithelial cells with squamoid differentiation (Figure 2) [4,11].…”

Section: Issn:2472-4971mentioning

confidence: 95%

Section: Issn:2472-4971mentioning

confidence: 96%

Section: Issn:2472-4971mentioning

confidence: 99%

Section: Issn:2472-4971mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Infiltrating Syringomatous Adenoma of the Nipple: A Case Report

Buckthought¹,

Gandhi²,

Popadich³

et al. 2017

J Med Surg Pathol

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Syringomatous adenoma of the nipple: A case series and systematic review

Park

Samat

Whitelock

et al. 2023

Clinical Case Reports

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Syringomatous adenoma of the nipple (SAN) is known to be a rare benign breast neoplasm. With a few cases documented in the literature, preoperatively diagnosing this tumor is a challenge, which often leads to invasive procedure such as mass excision with nipple removal. This study was aimed at presenting a case report of SAN and to conduct a review of published cases. Literature search was conducted through PubMed databases. Articles published from year 1983 to March of 2022 were included. Only histologically confirmed cases of SAN were included. The review was performed according to the PRISMA guidelines. Twenty-eight cases, How to cite this article: Park SK, Samat SH, Whitelock CM, Fortes T. Syringomatous adenoma of the nipple: A case series and systematic review.

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