Bilateral Squamous Cell Carcinoma of the External Auditory Canals

Wolfe, Stephen G.; Lai, Stephen Y.; Bigelow, Douglas C.

doi:10.1097/00005537-200206000-00012

Cited by 18 publications

(15 citation statements)

References 7 publications

(7 reference statements)

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“…We have never encountered a case with bilateral EACSCC, although such cases have been reported . Multiple factors in carcinogenesis exist for EACSCC.…”

Section: Discussionmentioning

confidence: 92%

Right dominance in the incidence of external auditory canal squamous cell carcinoma in the Japanese population: Does handedness affect carcinogenesis?

Tsunoda

Sumi

Terasaki³

et al. 2017

Laryngoscope Investig Oto

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Objectives/HypothesisTo investigate the relationship between handedness and the incidence of squamous cell carcinoma in the external auditory canal (EACSCC).Materials and MethodsSixty‐eight cases of EACSCC were enrolled in this study, and their affected side was checked. Handedness and ear‐picking habits were also investigated in 34 EACSCC cases. Handedness was judged based on self‐categorization, and the relationship between handedness and the affected side was investigated.ResultsFifty‐two cases occurred on the right side, and 16 cases occurred on the left side of patients with EACSCC. The incidence of laterality in EACSCC showed a statistically significant right dominance. Concerning handedness, 29 cases were right‐handed, 4 cases were left‐handed, and 1 case was ambidextrous. Twenty‐seven out of the 29 right‐handed cases and 1 ambidextrous case suffered from carcinoma on the right side, whereas 3 left‐handed cases suffered from carcinoma on the left side. That is, most of the cases suffered from EACSCC on the same side as their handedness, and this tendency showed a statistically significant difference. Most of the patients with EACSCC experienced itching and habitual ear‐picking in the affected side.ConclusionMechanical stimulations to the EAC, such as ear picking, may plausibly cause EACSCC. In Japan, ear picking, also called “mimikaki,” is a popular habit and an established unique culture. Because ear picking requires delicate handling and manipulation, this tends to occur on the same side as the handedness in the Japanese population. This is the first report about the relationship between handedness and carcinogenesis.Level of EvidenceN/A.

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“…We have never encountered a case with bilateral EACSCC, although such cases have been reported . Multiple factors in carcinogenesis exist for EACSCC.…”

Section: Discussionmentioning

confidence: 92%

Right dominance in the incidence of external auditory canal squamous cell carcinoma in the Japanese population: Does handedness affect carcinogenesis?

Tsunoda

Sumi

Terasaki³

et al. 2017

Laryngoscope Investig Oto

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“…Tumours of the ear canal are relatively uncommon in dogs 3 . To the best of the author's knowledge, bilateral aural neoplasia has not been reported in dogs, and only four case reports were found in the human literature 7–10 . Such cases are therefore considered extremely rare.…”

Section: Discussionmentioning

confidence: 97%

Bilateral ear canal neoplasia in three dogs

Zur

2005

Veterinary Dermatology

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Bilateral ear canal infections are common in dogs. Ear canal neoplasia is usually associated with unilateral problems, and is uncommon in dogs. To the best of the author's knowledge, bilateral aural neoplasia has not been reported in dogs, and only four case reports were found in the human literature. This report presents three dogs that had bilateral tumours in their ear canals. They were presented with bilateral otitis externa. All three dogs exhibited tissue proliferation of both ear canals that did not respond to glucocorticoids. Treatment consisted of total ear canal ablation, and tissues were submitted for histopathological evaluation. Case # 1 (a 10-year-old, male cocker spaniel) was diagnosed as ceruminious gland carcinoma. Cases # 2 and 3 were diagnosed as squamous cell carcinoma. Case # 1 was diagnosed 4 years earlier as having keratinization disorder, which was causing its chronic ear problems. Case # 2 (a 5-year-old, female French bulldog) was diagnosed 4 years earlier as having atopic dermatitis, which did not respond to hyposensitization, and only partially responded to glucocorticoids therapy. Case # 3 (a 9-year-old, male German shepherd) was diagnosed by the referring veterinarian as having unilateral ear canal proliferation 2 months prior to presentation. However, otoscopic examination showed bilateral proliferation that obstructed both canals. In summary, bilateral ear canal neoplasia should be considered in cases of nonresponsive, proliferative aural pathology.

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“…An incidence of 1 to 6 cases per million has been reported in the literature (Kinney, 1999;Barrs, 2001). There are 14 reports of bilateral squamous cell carcinoma published in the literature (Juby, 1957;Lederman, 1965;Hakata et al, 1976;Brookes, 1982;Milford and Violaris, 1987;Snyman and Claasen, 1988;Fontanel et al, 1989;Munk-Nielsen and Hansen, 1991;Kuhel et al, 1996;Knegt et al, 2002;Wolfe et al, 2002;Thevarajah et al, 2005;Shagdarsuren et al, 2006;Elsürer et al, 2007;Bibas et al, 2008). The clinical manifestations include a mass in the external auditory canal (EAC) or middle ear with or without otorrhoea, hearing impairment, facial palsy, vertigo and tinnitus (Manolidis et al, 1998;Moffat, 2003).…”

Section: Introductionmentioning

confidence: 99%