Bilateral slipped capital femoral epiphysis occuring in an adult with acromegalic gigantism

Feydy, A.; Carlier, Robert; Mompoint, D.; Rougereau, Grégoire; Patel, Amitkumar; Vallée, C.

doi:10.1007/s002560050218

Cited by 16 publications

(11 citation statements)

References 12 publications

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“…Twenty-seven articles were identified between the years 1953 and 2018 describing 32 cases of delayed-onset SCFE. 2,4567891011121314151617181920212223242526272829 Including the case presented in this article, 31 of the 33 cases (93.9%) of delayed-onset SCFE were associated with an endocrine disorder or pituitary tumor. See Table 1 for the endocrine disorders and pituitary tumors associated with delayed-onset SCFE identified in the literature review.…”

Section: Resultsmentioning

confidence: 91%

Slipped Capital Femoral Epiphysis in an Adult Patient With Kabuki Syndrome

2019

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Introduction:Slipped capital femoral epiphysis (SCFE) is a condition which predominantly occurs in adolescents. SCFE is extremely rare in adults, and nearly all previous reported cases have been associated with an endocrine disorder.Methods:We present a case of a 19-year-old man with Kabuki syndrome who was diagnosed with an unstable SCFE requiring surgical fixation. A literature search on PubMed and Google Scholar was done looking for all published cases of delayed-onset SCFE. All previous reported cases were reviewed to determine the likely cause of the SCFE.Results:No previous cases of SCFE were described in patients with Kabuki syndrome. Literature review revealed 27 articles describing 32 cases of delayed-onset SCFE. Thirty-one of these cases were associated with endocrine disorders or pituitary tumors. Endocrine disorders associated with delayed-onset SCFE included hypothyroidism, hypogonadism, and panhypopituitarism. Pituitary adenomas and craniopharyngiomas were also associated with delayed-onset SCFE.Discussion:This is the first reported case of SCFE in a patient with Kabuki syndrome. Kabuki syndrome is a genetic disorder known to cause delayed growth, resulting in delayed physeal closure, placing the patients at risk of SCFE even into adulthood. The literature search revealed that nearly all previously described delayed-onset SCFE cases were associated with endocrine disorders or pituitary tumors. We recommend that all patients diagnosed with delayed-onset SCFE be evaluated for endocrine disorders, pituitary tumors, and/or genetic disorders which can cause delayed skeletal maturation as these disorders can range from severe endocrine disorders to intracranial tumors.

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Section: Resultsmentioning

confidence: 91%

Slipped Capital Femoral Epiphysis in an Adult Patient With Kabuki Syndrome

2019

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“…Hyperostosis frontalis interna is a condition in which there is thickening of the internal table of the frontal bone and an association with pituitary gland disorders, acromegaly, toxic goiter, and diabetes has been reported in clinical literature (Fulton et al ., ; Waldron, ). Therefore, endocrine diseases such as gigantism and acromegaly can be associated with slipped femoral head, as observed in individual T.30 (Reeves et al ., ; Feydy et al ., ).…”

Section: Discussionmentioning

confidence: 97%

“The Roman Giant”: Overgrowth Syndrome in Skeletal Remains from the Imperial Age

Minozzi

Pantano

Catalano

et al. 2013

Intl J of Osteoarchaeology

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A very tall skeleton was found during archaeological excavations in the territory of Fidenae, an administrative centre of the Roman territorial organization, situated along the Via Salaria about 7 km north of Rome (Italy). The individual was a young male, dated back to the Imperial Age (3 rd century AD), presenting a very tall but normally proportioned stature, estimated around 202 cm. The long bones showed incomplete epiphyseal union; therefore, the stature would probably have been taller, if he had lived longer. In this work, the metric data are compared with those from the Roman Imperial Age population, and differential diagnosis is discussed.The skeletal evidence is characteristic of a form of gigantism, a rare growth disease that may be linked to different syndromes. The most common etiology is associated with a dysfunction of the pituitary gland, which causes overproduction of the growth hormone (hGH) during childhood. This endocrine disorder stimulates cartilaginous activity at the growth plate, delaying epiphyseal fusion and resulting in increased bone length.

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“…The capital femoral epiphyseal plate is more susceptible to shearing stress during growth, when a shortage of sex hormone compared with growth hormone causes a widening of the growth plate. Slipped femoral capital epiphysis has been associated with endocrine diseases including gigantism and acromegaly (Reeves et al, 1978;Feydy et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

A probable case of gigantism in a fifth Dynasty skeleton from the Western Cemetery at Giza, Egypt

Mulhern

2005

Int. J. Osteoarchaeol.

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Pituitary gigantism is a rare endocrine disorder caused by excess secretion of growth hormone during childhood. Individuals with this condition exhibit unusually tall stature due to prolonged growth as well as associated degenerative changes. Continued secretion of excess growth hormone during adulthood results in acromegaly, a related condition that results in bony overgrowth of the skull, hands and feet.

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Bilateral slipped capital femoral epiphysis occuring in an adult with acromegalic gigantism

Cited by 16 publications

References 12 publications

Slipped Capital Femoral Epiphysis in an Adult Patient With Kabuki Syndrome

Slipped Capital Femoral Epiphysis in an Adult Patient With Kabuki Syndrome

“The Roman Giant”: Overgrowth Syndrome in Skeletal Remains from the Imperial Age

A probable case of gigantism in a fifth Dynasty skeleton from the Western Cemetery at Giza, Egypt

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