Bilateral simultaneous inflammatory myofibroblastic tumor of the lung with distant metastatic spread

Carillo, Carolina; Anile, Marco; Giacomo, Tiziano De; Venuta, Federico

doi:10.1510/icvts.2011.271932

Cited by 20 publications

(23 citation statements)

References 9 publications

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“…Presently, it is believed to be a low-grade benign tumor characterized by the presence of a clonal population of cells; however, it has been known to occasionally behave in a locally invasive manner and even to metastasize. 4 The histopathologic appearance is characterized by the presence of myofibroblastic spindle-shaped cells in the background of an inflammatory cell infiltrate consisting of lymphocytes, plasma cells, and eosinophils. The cells are nonreactive for IgG4, which excludes IgG4-related pseudotumor, a close differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of the Trachea in the Pediatric Age Group

Jindal¹,

Bal²,

Agarwal³

2015

Journal of Bronchology &Amp; Interventional Pulmonology

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Inflammatory myofibroblastic tumors are uncommon tumors, which present as solitary masses in the pulmonary parenchyma. Tracheal involvement by these tumors is extremely rare and can be misdiagnosed as asthma. The closest histologic differential diagnoses are IgG4-related sclerosing pseudotumors, which are differentiated by IgG4 positivity. Fifty percent of inflammatory myofibroblastic tumors are positive for anaplastic lymphoma kinase gene rearrangements. The treatment modality of choice is surgical resection with therapeutic bronchoscopy reserved for patients presenting with acute airway obstruction or in those unwilling for surgery. New and upcoming treatments include anaplastic lymphoma kinase inhibitors like crizotinib.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Myofibroblastic Tumor of the Trachea in the Pediatric Age Group

Jindal¹,

Bal²,

Agarwal³

2015

Journal of Bronchology &Amp; Interventional Pulmonology

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“…IMT may occur at any age, but usually affects children and adults <40 years old (6,11). IMT primarily affects the lung, and accounts for 0.04–1% of all reported lung tumors (12,13).…”

Section: Introductionmentioning

confidence: 99%

Imaging observations of pulmonary inflammatory myofibroblastic tumors in patients over 40 years old

Zhu

et al. 2015

Oncology Letters

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Pulmonary inflammatory myofibroblastic tumors (PIMTs) are extremely rare in adults. If occurring in patients >40 years old, PIMT should be rapidly distinguished from lung cancer. The present study aimed to characterize the imaging features of PIMT in patients >40 years old in order to improve the diagnosis of PIMT. The imaging data of 10 patients with PIMT were reviewed retrospectively. Of the patients, eight underwent computed tomography (CT), two underwent positron emission tomography (PET)/CT and four underwent single-photon emission computed tomography (SPECT). Unenhanced CT revealed 10 lesions with a maximum diameter ranging between 5 and 57 mm located in the lower (n=6) or upper (n=4) lobe, in a peripheral (n=9) or central (n=1) region, and that were well- (n=4) or ill-defined (n=6), and round to oval (n=5) or irregular (n=5) in shape. Calcification (n=3), necrosis (n=6), cavity (n=4), air bronchogram (n=6) and obstructive pneumonia (n=1) were also observed in the patients. Contrast-enhanced CT revealed six lesions with moderate to high contrast enhancement in the arterial and venous phases, including four lesions with delayed enhancement. PET/CT identified two lesions with increased tracer uptake that were homogeneous and heterogeneous and each exhibited a maximal standard uptake value (SUVmax) of 6.0 and 5.4, respectively. The delayed PET/CT revealed foci that each exhibited an increased SUVmax of 6.9 and 5.9, respectively. SPECT demonstrated no definitive bone metastases, but did reveal atypical hypertrophic pulmonary osteoarthropathy in one patient. The combined imaging methods may lead to a more precise evaluation of PIMT in patients >40 years old.

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“…Carillo et al 5 and Gallego et al 9 have reported cases of IMT of the lung with adrenal gland and maxillary metastases, respectively. The term, IFS has been utilised to classify these tumours with aggressive nature and metastases 3 9…”

Section: Discussionmentioning

confidence: 99%

“…However, the term IMT was coined around two decades ago owing to its distinctive pathological and molecular features 7. Although these tumours were initially regarded to be benign and non-neoplastic, it is now widely accepted that these tumours may have a tendency to grow aggressively leading to local invasion to adjacent organs, recurrence and distant metastasis 5 9…”

Section: Introductionmentioning

confidence: 99%

A rare aetiology of respiratory failure in a 10-year-old boy: inflammatory myofibroblastic tumour

et al. 2013

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SUMMARYPrimary neoplasms of the respiratory tract are rarely encountered in the paediatric population. Inflammatory myofibroblastic tumour (IMT) is a rare soft tissue mesenchymal tumour but a distinct disease entity accounting for less than 1% of all primary lung tumours. We report a case of a 10-year-old boy who presented with respiratory failure and left lung collapse. On flexible fiberoptic bronchoscopy, a pedunculated mass in the lower part of the trachea originating from the left main stem bronchus was identified. The patient subsequently underwent a left-sided pneumonectomy with complete resection of the mass. The histopathological analysis was consistent with IMT. Two years of follow-up and the patient remains well. BACKGROUND

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Bilateral simultaneous inflammatory myofibroblastic tumor of the lung with distant metastatic spread

Cited by 20 publications

References 9 publications

Inflammatory Myofibroblastic Tumor of the Trachea in the Pediatric Age Group

Inflammatory Myofibroblastic Tumor of the Trachea in the Pediatric Age Group

Imaging observations of pulmonary inflammatory myofibroblastic tumors in patients over 40 years old

A rare aetiology of respiratory failure in a 10-year-old boy: inflammatory myofibroblastic tumour

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