Bilateral serous detachment of retina: an unusual mode of revelation of thrombotic thrombocytopenic purpura of favorable outcome with plasma exchange

Titah, Chérif; Abisror, Noémie; Affortit, Aude; Buffet, M.; Coppo, Paul

doi:10.1007/s00417-013-2306-7

Cited by 4 publications

(11 citation statements)

References 4 publications

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“…Reprint requests: Joshua Robinson, MD, 124 Sunset Court, West Columbia, SC 29169; e-mail: Jrobinson@palmettoretina.com DELAYED RECOVERY AFTER TTP-RELATED ERDS significant visual recovery without complete resolution of subretinal fluid after 13 days. 9 Visual outcomes were excellent for all patients, but the recovery period was variable, ranging from days to months.…”

Section: Discussionmentioning

confidence: 89%

Profound Visual Recovery at 16 Months After Resolution of Serous Retinal Detachments Secondary to Thrombotic Thrombocytopenic Purpura: Case Report and Literature Review

Williams

Pearce

Smith

et al. 2021

RETINAL Cases &Amp; Brief Reports

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Purpose: To report a unique case of dramatic improvement in objective visual function during the recovery phase, after resolution of thrombotic thrombocytopenic purpurarelated serous retinal detachments and to review prognostic trends in reported cases involving the macula.Methods: Observational case report and literature review.Results: A 36-year-old white woman with thrombotic thrombocytopenic purpura developed vision loss from serous retinal detachments in both eyes. Over a 16-month period, after both retinae remained attached, best-corrected visual acuity improved from 20/400 to 20/50 in both eyes with dramatic improvement on optical coherence tomography and autofluorescence imaging.Conclusion: Although thrombotic thrombocytopenic purpura is a life-threatening illness, visual prognosis in patients with macula off serous retinal detachments appears excellent. Most cases reviewed in literature improved to baseline visual acuity, but recovery periods ranged from days to many months. Hyperautofluorescent granularity on autofluorescence photography may be an indicator of chronic retinal detachment and a more delayed visual recovery.

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Section: Discussionmentioning

confidence: 89%

Profound Visual Recovery at 16 Months After Resolution of Serous Retinal Detachments Secondary to Thrombotic Thrombocytopenic Purpura: Case Report and Literature Review

Williams

Pearce

Smith

et al. 2021

RETINAL Cases &Amp; Brief Reports

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“…10 Another 32-year-old woman with TTP-associated serous retinal detachment also achieved significant of visual acuity after 6 days of treatment with PLEX and steroids. 19 Another case report noted a young female who developed bilateral serous retinal detachments from TTP that was treated with PLEX and rituximab, with improvement in vision from 20/400 to 20/50 in the span of 16 months. 13 A paediatric patient who presented with orbital and nasal mucosal bleeding had improvement in the platelet count after three sessions of PLEX, but required 3 months for resolution of the ocular bleeding with long-term vision impairment.…”

Section: Discussionmentioning

confidence: 99%

“…One 46-year-old woman with recurrent TTP presented with sudden vision loss due to unilateral exudative retinal detachment received treatment with PLEX and steroids resulting in improvement in her vision symptoms starting at day 2 10. Another 32-year-old woman with TTP-associated serous retinal detachment also achieved significant of visual acuity after 6 days of treatment with PLEX and steroids 19. Another case report noted a young female who developed bilateral serous retinal detachments from TTP that was treated with PLEX and rituximab, with improvement in vision from 20/400 to 20/50 in the span of 16 months 13.…”

Section: Discussionmentioning

confidence: 99%

Near-complete vision recovery from bilateral serous retinal detachment associated with thrombotic thrombocytopenic purpura

Nguyen

Radhakrishnan

et al. 2022

BMJ Case Rep

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Ocular manifestations of thrombotic thrombocytopenic purpura (TTP) are uncommon, and bilateral retinal detachment is a rare presentation of TTP. We report a rare case of bilateral retinal detachment from underlying TTP in a patient presenting with vision loss. A 56-year-old man presented with a 4-day history of bilateral vision loss. Bilateral serous retinal detachment was confirmed using dilated ophthalmoscope examination. Laboratory results were significant for severe thrombocytopenia, peripheral smear revealed numerous schistocytes and ADAMTS13 activity of less than 1%. The patient was treated with plasma exchange (PLEX), prednisone, rituximab and caplacizumab. This case report highlights that prompt treatment of TTP with PLEX, prednisone, rituximab and caplacizumab could result in significant vision recovery.

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“…In our patient, the blood pressure was normal, and there was no other sign of hypertensive retinopathy. Only 3 other cases unrelated to hypertension have been reported [ 2 , 3 , 4 ]. However, for 2 of the 3 cases, other risk factors for exudative retinal detachment were present, such as a postpartum context [ 3 ] or a retinal pigment epithelium tear [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Only 3 other cases unrelated to hypertension have been reported [ 2 , 3 , 4 ]. However, for 2 of the 3 cases, other risk factors for exudative retinal detachment were present, such as a postpartum context [ 3 ] or a retinal pigment epithelium tear [ 2 ]. This suggests that hypertension probably plays an important role in the development of exudative retinal detachment in TTP, but other factors remain to be identified.…”

Section: Discussionmentioning

confidence: 99%

Exudative Retinal Detachment Treatment in a Patient with Thrombotic Thrombocytopenic Purpura

Sampo

Yin

Hoffart

et al. 2016

Case Rep Ophthalmol

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Purpose: We report a case of unilateral exudative retinal detachment in a patient with thrombotic thrombocytopenic purpura (TTP), without associated hypertension, successfully treated with plasmapheresis. Case Report: A 46-year-old woman with a medical history of TTP presented with unilateral exudative retinal detachment. Biological and radiological assessment eliminated other causes of exudative retinal detachment, including hypertension. Plasma exchange was performed, followed by a rapid improvement in visual acuity and total disappearance of serous detachment. Conclusion: Exudative unilateral retinal detachment is a rare complication of TTP and can be successfully treated by plasma exchange.

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Bilateral serous detachment of retina: an unusual mode of revelation of thrombotic thrombocytopenic purpura of favorable outcome with plasma exchange

Cited by 4 publications

References 4 publications

Profound Visual Recovery at 16 Months After Resolution of Serous Retinal Detachments Secondary to Thrombotic Thrombocytopenic Purpura: Case Report and Literature Review

Profound Visual Recovery at 16 Months After Resolution of Serous Retinal Detachments Secondary to Thrombotic Thrombocytopenic Purpura: Case Report and Literature Review

Near-complete vision recovery from bilateral serous retinal detachment associated with thrombotic thrombocytopenic purpura

Exudative Retinal Detachment Treatment in a Patient with Thrombotic Thrombocytopenic Purpura

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