Bilateral sequential theta burst stimulation for multiple-therapy-resistant depression: A naturalistic observation study

Burhan, Amer M.; Patience, James; Teselink, Johannes; Marlatt, Nicole M.; Babapoor-Farrokhran, Sahand; Palaniyappan, Lena

doi:10.1016/j.jpsychires.2020.08.009

Cited by 5 publications

(12 citation statements)

References 34 publications

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“…Our results demonstrate 58.3% to 72.2% improvement in depressive symptoms in patients receiving biTBS after treatment and during follow‐ups. These are similar to or higher than results obtained by previous studies using biTBS protocols delivering 600 pulses to each site 7,10,28 . Plewnia et al .…”

Section: Discussionsupporting

confidence: 90%

“…(2014) had a 56% response rate after 20 sessions. Burhan et al 10 . had a 52% response rate in 50 patients with TRD after 20 sessions in a naturalistic setting.…”

Section: Discussionmentioning

confidence: 98%

“…4 Two TBS patterns modulate cortical activity differently. Continuous TBS (cTBS) produces long-term, depression-like cortical effects by delivering uninterrupted pulses, while intermittent TBS (iTBS) produces long-term potentiation-like effects by alternating 10 bursts with nonstimulation intervals lasting 8 s. 5 Several recent studies [6][7][8][9][10] have demonstrated the antidepressant efficacy of biTBS (i.e. cTBS to the right DLPFC and iTBS to the left DLPFC) in patients with major depressive disorder (MDD).…”

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confidence: 99%

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Bilateral theta‐burst stimulation on emotional processing in major depressive disorder: A functional neuroimaging study from a randomized, double‐blind, sham‐controlled trial

Chou

Chen

et al. 2023

Psychiatry Clin Neurosci

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Aim: Bilateral theta-burst stimulation (biTBS; intermittent TBS over the left dorsolateral prefrontal cortex [DLPFC] and continuous TBS over the right DLPFC) has demonstrated efficacy in improving symptoms in patients with major depressive disorder (MDD). However, the underlying brain mechanisms remain unknown. The authors aimed to investigate the antidepressant efficacy of biTBS monotherapy and its effects on the brain responses measured by functional magnetic resonance imaging (fMRI) during emotional processing in MDD. Methods:The authors conducted a double-blind, randomized, sham-controlled trial of patients with MDD who exhibited no responses to at least one adequate antidepressant treatment for the prevailing episode. Recruited patients were randomly assigned to 10 biTBS monotherapy or sham stimulation sessions. The fMRI scans during performing emotional recognition task were obtained at baseline and after 10 sessions of treatment. Depressive symptoms were assessed using the 21-item Hamilton Rating Scale for Depression at baseline and the weeks 4, 8, 12, 16, 20, and 24 week.Results: The biTBS group (n = 17) exhibited significant decreases in depression scores compared with the sham group (n = 11) at week 8 (70% vs 40%; P = 0.02), and the significant differences persisted during the 24-week followup periods. At week 4, when the treatment course was completed, patients in the biTBS group, but not in the sham group, exhibited increased brain activities over the left superior and middle frontal gyrus during negative emotional stimuli. Conclusion:The authors' findings provide the first evidence regarding the underlying neural mechanisms of biTBS therapy to improve clinical symptoms in patients with MDD.

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Section: Discussionsupporting

confidence: 90%

“…(2014) had a 56% response rate after 20 sessions. Burhan et al 10 . had a 52% response rate in 50 patients with TRD after 20 sessions in a naturalistic setting.…”

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

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Bilateral theta‐burst stimulation on emotional processing in major depressive disorder: A functional neuroimaging study from a randomized, double‐blind, sham‐controlled trial

Chou

Chen

et al. 2023

Psychiatry Clin Neurosci

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“…The TMS Machine (Magstim ® Rapid 2, UK) was used to apply the paradigm published previously [ 16 ]. Briefly, 600 pulses of continuous TBS (cTBS) was applied to F4 location and subsequently iTBS to F3 location with burst frequency between 40 and 50 Hz.…”

Section: Methodsmentioning

confidence: 99%

“…With respect to burst sequence, Plewnia et al [ 15 ] found that the bilateral TBS protocol, that we used, was safe and superior to sham stimulation for the treatment of major depression. Further, we recently reported good efficacy and tolerability for bilateral sequential theta-burst applications in TRD [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Bilateral sequential theta burst stimulation in depressed veterans with service related posttraumatic stress disorder: a feasibility study

et al. 2022

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Background Depression comorbid with posttraumatic stress disorder (PTSD) can be disabling and treatment resistant. Preliminary evidence suggests that repetitive transcranial magnetic stimulation (rTMS), may have a role in helping these patients. There are only few published studies using different rTMS paradigms including bilateral intermittent theta burst (iTBS) and low frequency rTMS. Methods In this small cohort observation study, we examined the efficacy of bilateral sequential theta-burst stimulation (bsTBS) in 8 treatment resistant depression (TRD) military veterans with PTSD comorbidity stemming from military service experience. Results bsTBS was generally well tolerated and resulted in 25% and 38% remission and response rates on Depression scores respectively; 25% remission and response rate on PTSD scores. Discussion This study demonstrates preliminary feasibility and safety of bsTBS in TRD with comorbid military service related PTSD. We concluded that this paradigm might hold promise as a therapeutic tool to help patients with TRD co-morbid with military service related PTSD. Further adequately powered studies to compare rTMS treatment paradigms in this patient group are warranted.

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A real-world retrospective cohort study comparing two bilateral stimulation protocols of add-on rTMS in patients with treatment resistant depression and severe anxiety

Kabar,

Lopez-Chau,

Araujo-Banchon

2024

Asian Journal of Psychiatry

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Bilateral sequential theta burst stimulation for multiple-therapy-resistant depression: A naturalistic observation study

Abstract: doi: medRxiv preprint NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.

Cited by 5 publications

References 34 publications

Bilateral theta‐burst stimulation on emotional processing in major depressive disorder: A functional neuroimaging study from a randomized, double‐blind, sham‐controlled trial

Bilateral theta‐burst stimulation on emotional processing in major depressive disorder: A functional neuroimaging study from a randomized, double‐blind, sham‐controlled trial

Bilateral sequential theta burst stimulation in depressed veterans with service related posttraumatic stress disorder: a feasibility study

A real-world retrospective cohort study comparing two bilateral stimulation protocols of add-on rTMS in patients with treatment resistant depression and severe anxiety

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