Bilateral Sequential Paracentral Acute Middle Maculopathy

Müftüoğlu, İlkay Kılıç; Tokuç, Ecem Önder; Karabaş, V. Levent

doi:10.4274/tjo.galenos.2021.50207

Cited by 2 publications

(9 citation statements)

References 6 publications

(5 reference statements)

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“…It is generally believed that PAMM is associated with retinal vascular disorders, mainly RVO, although no definite risk factor has been reported for sequential PAMM. 13 Unlike in another case of sequential PAMM, 5 our patient did not have a history of systemic vascular or ischemic events and did not contract the COVID infection or receive a vaccination. More studies to elucidate the pathobiology of PAMM to prevent permanent vision loss are necessary.…”

Section: Discussionmentioning

confidence: 73%

“…12 However, sequential PAMM was only reported in patients with systemic vasculopathy and hypertension. 5…”

Section: Discussionmentioning

confidence: 99%

“…The higher rate of PAMM detected on OCT in patients with mild hypertension indicates that these early alterations in retinal microcirculation might become evident before changes in OCTA parameters. 2,5…”

Section: Discussionmentioning

confidence: 99%

“…1 PAMM can present as an isolated entity, even in asymptomatic patients with unknown systemic disease, 2 or can be associated with diabetic retinopathy, hypertensive retinopathy, sickle cell retinopathy, retinal artery occlusion (RAO), retinal vein occlusion (RVO), Purtscher retinopathy, and giant cell arteritis (GCA). [3][4][5][6] Here, we report a patient with an ocular history of PAMM caused by reperfused central retinal artery occlusion (CRAO) in 1 eye who presented with PAMM in the opposite eye 3 years later. To our knowledge, this is the first report of sequential PAMM in a patient with no history of systemic cardiovascular or ischemic events.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sequential Bilateral Paracentral Acute Middle Maculopathy in a Middle-Aged Woman

Jabbehdari

Uwaydat

2023

Journal of VitreoRetinal Diseases

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Purpose: To present a case of sequential paracentral acute middle maculopathy (PAMM) in a middle-aged woman with no cardiovascular risk factors. Methods: A single case was evaluated. Results: A 53-year-old woman with a history of PAMM resulting from perfused central retinal artery occlusion in the left eye presented with PAMM in the right eye 3 years later. The patient had a medical history of treated anemia, stress disorder, and insomnia. Examination of the right eye showed a superior parafoveal crescent of translucent retina without associated edema or hemorrhage. Optical coherence tomography (OCT) showed hyperreflective band-like areas in the superior parafoveal and perifoveal regions. Fluorescein angiography revealed normal arterial filling. OCT angiography showed patchy filling of the middle capillary plexus with normal perfusion of the superficial capillary plexus in the right eye. Conclusions: Although bilateral sequential PAMM is rare, close monitoring in a case of PAMM in 1 eye should be considered.

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Section: Discussionmentioning

confidence: 73%

“…12 However, sequential PAMM was only reported in patients with systemic vasculopathy and hypertension. 5…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sequential Bilateral Paracentral Acute Middle Maculopathy in a Middle-Aged Woman

Jabbehdari

Uwaydat

2023

Journal of VitreoRetinal Diseases

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Retinal Ischemic Perivascular Lesions in Individuals With Atrial Fibrillation

Bakhoum

Madala

Lando

et al. 2023

JAHA

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Background We previously demonstrated that retinal ischemic perivascular lesions (RIPLs), which are indicative of ischemia in the middle retina, may be a biomarker of ischemic cardiovascular disease. In this study, we sought to determine the relationship between RIPLs and atrial fibrillation, a common source of cardiac emboli. Methods and Results In this case‐control study, we identified individuals between the ages of 50 and 90 years who had undergone macular spectral domain optical coherence tomography imaging. Individuals with atrial fibrillation were identified, and age‐ and sex‐matched individuals from the same pool, but without a diagnosis of atrial fibrillation, were selected as controls. Spectral domain optical coherence tomography scans were reviewed by 3 independent and masked observers for presence of RIPLs. The relationship between RIPLs and atrial fibrillation was analyzed using multivariable logistic regression models. There were 106 and 91 subjects with and without atrial fibrillation, respectively. The percentage of subjects with RIPLs was higher in the atrial fibrillation group compared with the control group (57.5% versus 37.4%; P =0.005). After adjusting for age, sex, smoking history, hypertension, diabetes, coronary artery disease, carotid stenosis, stroke, and myocardial infarction, the presence of RIPLs was significantly associated with atrial fibrillation, with an odds ratio of 1.91 (95% CI, 1.01–3.59). Conclusions RIPLs are significantly associated with atrial fibrillation, independent of underlying ischemic heart disease or cardiovascular risk factors. This association may inform the diagnostic cardiovascular workup for individuals with RIPLs incidentally detected on optical coherence tomography scan of the macula.

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Bilateral Sequential Paracentral Acute Middle Maculopathy

Cited by 2 publications

References 6 publications

Sequential Bilateral Paracentral Acute Middle Maculopathy in a Middle-Aged Woman

Sequential Bilateral Paracentral Acute Middle Maculopathy in a Middle-Aged Woman

Retinal Ischemic Perivascular Lesions in Individuals With Atrial Fibrillation

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