Bilateral Sequential Non-Arteritic Anterior Ischaemic Optic Neuropathy Following Repeat Influenza Vaccination

Manasseh, Gemma S L; Donovan, Debbie; Shao, Emily Han; Taylor, Simon

doi:10.1159/000366472

Cited by 14 publications

(7 citation statements)

References 7 publications

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“…It commonly presents with an altitudinal field defect. Post-vaccination NAION has also been previously reported following influenza vaccination ( Kawasaki, Purvin and Tang, 1998 , Manasseh et al, 2014 ).…”

Section: Discussionmentioning

confidence: 55%

Optic neuropathy after COVID-19 vaccination: Case report and systematic review

Haseeb

Elhusseiny

Chauhan

et al. 2022

Neuroimmunology Reports

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Section: Discussionmentioning

confidence: 55%

Optic neuropathy after COVID-19 vaccination: Case report and systematic review

Haseeb

Elhusseiny

Chauhan

et al. 2022

Neuroimmunology Reports

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“…It commonly manifests as an altitudinal field defect. Post-vaccination NAION was also reported following the administration of the influenza vaccine [ 69 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Vaccine-Associated Optic Neuropathy: A Systematic Review of 45 Patients

Elnahry

Al-Nawaflh²,

Eldin³

et al. 2022

Vaccines

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We provide a systematic review of published cases of optic neuropathy following COVID-19 vaccination. We used Ovid MEDLINE, PubMed, and Google Scholar. Search terms included: “COVID-19 vaccination”, “optic neuropathy”, “optic neuritis”, and “ischemic optic neuropathy”. The titles and abstracts were screened, then the full texts were reviewed. Sixty eyes from forty-five patients (28 females) were included. Eighteen eyes from fourteen patients (31.1%) were diagnosed with anterior ischemic optic neuropathy (AION), while 34 eyes from 26 patients (57.8%) were diagnosed with optic neuritis (ON). Other conditions included autoimmune optic neuropathy and Leber hereditary optic neuropathy. Fifteen patients (33.3%) had bilateral involvement. The mean age of all patients was 47.4 ± 17.1 years. The mean age of AION patients was 62.9 ± 12.2 years and of ON patients was 39.7 ± 12.8 years (p < 0.001). The mean time from vaccination to ophthalmic symptoms was 9.6 ± 8.7 days. The mean presenting visual acuity (VA) was logMAR 0.990 ± 0.924. For 41 eyes with available follow-up, the mean presenting VA was logMAR 0.842 ± 0.885, which improved to logMAR 0.523 ± 0.860 at final follow-up (p < 0.001). COVID-19 vaccination may be associated with different forms of optic neuropathy. Patients diagnosed with ON were more likely to be younger and to experience visual improvement. More studies are needed to further characterize optic neuropathies associated with COVID-19 vaccination.

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“…Regarding these cases, the close temporal relationship with vaccination makes us think that it was the predisposing event that triggered non-arteritic anterior ischemic neuropathy in these 2 patients. Although NA-AION after vaccination is very rare, 4 cases after influenza vaccination have been reported in the literature [ 18 , 19 ], and very recently, another case of NA-AION with a close temporal relationship with COVID-19 vaccination has been published [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Ischemic Optic Neuropathy After Administration of a SARS-CoV-2 Vaccine: A Report of 2 Cases

Franco

Fonollosa

2022

Am J Case Rep

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Case series Patients: Male, 53-year-old • Male, 65-year-old Final Diagnosis: Ischemic optic neuropathy Symptoms: Visual acuity loss • visual field defect Medication: — Clinical Procedure: — Specialty: Ophthalmology Objective: Rare coexistence of disease or pathology Background: Since the start of vaccination efforts against COVID-19, several presumed secondary ocular events have been described. We present 2 cases of non-arteritic anterior ischemic optic neuropathy (NA-AION) in patients whose symptoms appeared in the first 2 weeks after administration of the Pfizer-BioNTech COVID-19 mRNA BNT162b2/ Cominarty vaccine. Case Reports: The first patient was a 53-year-old man who presented visual field disturbance in the right eye 7 days after the first vaccine dose, and who consulted a physician 10 days after the second dose, when he experienced loss of vision in the left eye. After a full examination, bilateral anterior optic disc neuropathy was diagnosed. The second patient was a 65-year-old man who presented anterior optic disc neuropathy 12 days after his first vacci-nation. In both cases, arteritic origin was ruled out due to absence of systemic symptoms and because of normal levels of C-reactive protein and erythrocyte sedimentation rates. Conclusions: Ischemic optic neuropathy is a rare adverse ocular secondary effect of COVID-19 vaccines. Further basic and clinical research is needed to elucidate the pathogenic mechanisms and better characterize the clinical picture of this entity.

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Bilateral Sequential Non-Arteritic Anterior Ischaemic Optic Neuropathy Following Repeat Influenza Vaccination

Abstract: A 68-year-old man developed bilateral sequential non-arteritic anterior ischaemic optic neuropathy, each episode occurring with a close temporal relationship to influenza vaccination.

Cited by 14 publications

References 7 publications

Optic neuropathy after COVID-19 vaccination: Case report and systematic review

Optic neuropathy after COVID-19 vaccination: Case report and systematic review

COVID-19 Vaccine-Associated Optic Neuropathy: A Systematic Review of 45 Patients

Ischemic Optic Neuropathy After Administration of a SARS-CoV-2 Vaccine: A Report of 2 Cases

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