Bilateral retrobulbar neuritis in an adolescent boy with lymphoma

Bamrolia, Naina R.; Yadava, Usha; Anand, Abhishek; Zia, Chaudhuri

doi:10.1016/j.jaapos.2010.11.013

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…Although rare, optic neuropathies may arise in the setting of primary CNS Non-Hodgkin lymphomas (NHL) and paraneoplastic syndromes ( 38 – 43 ). As in CVID there is an increased risk of developing NHL ( 4 , 44 , 45 ), total body PET/CT and CSF analysis were performed, yielding negative results.…”

Section: Discussionmentioning

confidence: 99%

Central Nervous System Involvement in Common Variable Immunodeficiency: A Case of Acute Unilateral Optic Neuritis in a 26-Year-Old Italian Patient

et al. 2018

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Common Variable Immunodeficiency (CVID) is a group of heterogeneous primary immunodeficiencies sharing defective B lymphocytes maturation and dysregulated immune response and resulting in impaired immunoglobulin production. Clinical picture encompasses increased susceptibility to infections, hematologic malignancies, inflammatory, and autoimmune diseases. Neurological manifestations are uncommon and optic neuritis has been previously reported only in one case with bilateral involvement. We hereby report a case of a 26-year-old man affected by CVID undergoing regular immunoglobulin supplementation, who presented with acute unilateral demyelinating optic neuritis and lymphocytic pleocytosis in the cerebrospinal fluid. A variety of infectious, inflammatory, and neoplastic conditions were excluded and a diagnosis of clinically isolated optic neuritis was made. The patient was treated with a short course of intravenous steroids with complete recovery. Overall, this case expands our current knowledge about clinical spectrum of complications in CVID and highlights the need for further research about this complex disease.

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