Bilateral Proptosis as Initial Manifestation of Mantle Cell Lymphoma

Walia, Sandeep; Stelton, Christopher R.; Shantha, Jessica G.; Connors, Daniel B.; Walia, Harpreet S.

doi:10.1016/j.amjmed.2013.03.023

Cited by 1 publication

(1 citation statement)

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“…Intra-cranial diseases include cavernous haemangioma, fistula and meningioma. Palpebral involvement is mainly due to lymphoma, leukaemia or thyroid ophthalmopathy [1] . The diagnosis may be difficult and require invasive procedures.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Bilateral Proptosis

Serôdio

Jonet

Trinidade

et al. 2018

European Journal of Case Reports in Internal Medicine

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A 65-year-old man presented with a 2-year history of severe bilateral proptosis, palpable lymphadenopathy and moderate hepatosplenomegaly. A blood test was positive for hepatitis C infection. CT showed palpebral infiltrative lesions with regional progression through the temporal and masticatory spaces to the pharynx and hypopharynx causing almost complete airway obstruction. A palpebral biopsy was consistent with low-grade Bcl-2+ extra-nodal MALT non-Hodgkin B-cell lymphoma. The patient received six cycles of rituximab-based chemotherapy with clinical remission at 9-month follow-up. Bilateral proptosis is a rare presentation of several diseases. When brain CT excludes cavernous sinus pathology, thyroid ophthalmopathy or haematological malignancy should be considered.LEARNING POINTSBilateral proptosis is a rare presentation with a broad differential diagnosis, and is most frequently is caused by cavernous sinus disease, thyroid ophthalmopathy or haematological malignancy.Hepatitis C may be associated with MALT lymphoma and presents mainly at non-gastric locations even with few hepatic manifestations of the infection.Long-term low-grade lymphoma may present with severe disseminated disease at diagnosis, but treatment response is generally good.

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Section: Discussionmentioning

confidence: 99%