Bilateral Primary Optic Nerve Lymphoma

Millar, Michael James; Tumuluri, Krishna; Murali, Rajmohan; Ng, Teck Han; Beaumont, Paul; Maloof, Anthony

doi:10.1097/iop.0b013e318160744b

Cited by 13 publications

(4 citation statements)

References 8 publications

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Section: Discussionmentioning

confidence: 99%

“…Alternately, our broader search leads us to conclude that the potential for both neoplastic infiltration and the predilection to cause leptomeningeal carcinomatosis/lymphoma of the anterior visual segments is considerably more common. [26][27][28][29][30] Systematic ascertainment has demonstrated a rate as high as 90%, 31 with a concordance rate of systemic involvement in greater than half of those with histopathologic confirmation of lymphomatous infiltration of the optic nerve. 29 A study involving patients with confirmed leptomeningeal carcinomatosis revealed that vision loss was the predominant ocular symptom in over 70%, while half reported that their visual disturbance was their initial and the corresponding symptom which prompted them to seek out medical attention.…”

Section: Discussionmentioning

confidence: 99%

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Recurrent Optic Neuritis and Perineuritis Followed by an Unexpected Discovery

Maldonado

Lisak

Galetta

et al. 2023

Neurol Neuroimmunol Neuroinflamm

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We describe a woman with a history of relapsing acute optic neuritis and perineuritis. Testing failed to confirm a specific diagnosis; hence, she was diagnosed with seronegative neuromyelitis optica spectrum disorder and treated with the immunotherapy rituximab, later in conjunction with mycophenolate mofetil. She achieved a durable remission for 9 years until she presented with paresthesia affecting her left fifth digit, right proximal thigh, and left foot, while also reporting a 25-pound weight loss over the prior 3 months. New imaging demonstrated a longitudinally extensive and enhancing optic nerve, in conjunction with multifocal enhancing lesions within the spinal cord, in a skip-like distribution. The differential diagnosis is discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recurrent Optic Neuritis and Perineuritis Followed by an Unexpected Discovery

Maldonado

Lisak

Galetta

et al. 2023

Neurol Neuroimmunol Neuroinflamm

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“…41 Limitations of a medial conjunctival biopsy include obtaining only a small amount of tissue for, as well as accessing only the most anterior portion of the optic nerve. Previously reported patients who underwent optic nerve biopsy for lymphoma had no significant visual deterioration.…”

Section: Optic Nerve Biopsy Indications and Techniquesmentioning

confidence: 99%

Optic nerve lymphoma: Report of two cases and review of the literature

Kim

Mendoza

Rashid

et al. 2015

Survey of Ophthalmology

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Lymphoma may involve the optic nerve as isolated optic nerve lymphoma or in association with CNS or systemic lymphoma. We present two biopsy-proven non-Hodgkin lymphomas of the optic nerve and compare our findings with previously reported cases. We discuss the mechanism of metastasis, classification of optic nerve involvement, clinical features, radiologic findings, optic nerve biopsy indications and techniques, histologic features, and treatments. We propose a classification system of optic nerve lymphoma: isolated optic nerve involvement, optic nerve involvement with CNS disease, optic nerve involvement with systemic disease, and optic nerve involvement with primary intraocular lymphoma. Although it is an uncommon cause of infiltrative optic neuropathy, optic nerve metastasis should be considered in patients with a history of lymphoma. The recommended approach to a patient with presumed optic nerve lymphoma includes neuroimaging, and cerebrospinal fluid evaluation as part of the initial work-up, then judicious use of optic nerve biopsy, depending on the clinical situation.

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“…To date, most reports of ONBs in the literature have been limited to single case reports and highlight the need to consider a broad differential diagnoses and to perform extensive evaluations before biopsy (2)(3)(4)(5)(6). We performed a retrospective review at a tertiary care institute to identify patients who underwent ONB.…”

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confidence: 99%