Bilateral primary angiosarcoma of the breast: a case report

Ooe, Yuka; Terakawa, Hirofumi; Kawashima, Hiroko; Ikeda, Hiroko; Inaki, Noriyuki

doi:10.1186/s13256-023-03791-7

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…A diagnosis obtained by MRI may be more accurate than that obtained by mammography or ultrasonography [20,21]. On MRI, the tumor tends to be hypointense on T1weighted images and hyperintense on T2-weighted images [22]. On dynamic MRI, high-grade breast angiosarcoma exhibits typical malignant dynamic features with a rapid washout pattern, whereas low-grade tumors show persistent enhancement on delayed images, which can help with differentiation of these masses [23].…”

Section: Discussionmentioning

confidence: 99%

Primary Angiosarcoma of the Breast: A 20-Year Single-Institution Experience in China

Tian,

Li,

et al. 2023

European Journal of Cancer Care

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Background. Primary angiosarcoma of the breast (PAS) is a rare aggressive tumor with no standardized treatment. The aim of this study was to investigate the characteristics of all primary angiosarcoma of the breast obtained from a single center and the features peculiar to Chinese patients. Methods. The medical records at Tianjin Medical University Cancer Institute and Hospital were retrospectively searched to identify all cases of PAS treated in 2000–2019. Results. Sixteen cases of PAS were identified, and most involved the left breast. Forty percent of young patients had a history of progressive tumor enlargement with localized pain and skin color changes. The diagnostic accuracy rate was 66.7% for MRI, 75% for core-needle aspiration, and 58.3% for intraoperative fast frozen pathology. The most common surgery was modified radical mastectomy (n = 9, 56.25%). All positive margins involved the pectoralis major muscle, and these tumors’ mean size was 8.2 cm. All cases were CD34 positive, and the Ki-67 index was ≥30% in 37.5%. Median local or distant recurrence-free survival was 57.6 months for low-to-moderate-grade tumors and 23.5 months for high-grade tumors. Seventy-five percent of the patients were treated with chemotherapy. The average tumor size in patients with relapse-free survival longer than 3 years was 2.2 cm. Conclusion. Young patients may have larger and softer breast tumors with skin color changes. MRI and core-needle biopsy should be performed preoperatively. A positive surgical margin at pectoralis major should be noted. Breast prosthesis may be a better reconstruction option. Adjuvant chemotherapy and/or radiotherapy should be considered for large tumors with a high Ki-67 index or high-grade tumors.

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Section: Discussionmentioning

confidence: 99%

Primary Angiosarcoma of the Breast: A 20-Year Single-Institution Experience in China

Tian,

Li,

et al. 2023

European Journal of Cancer Care

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“…On post-contrast images, a vivid heterogeneous enhancement was demonstrated [40]. In particular, the kinetic enhancement is strictly linked to tumor grade: the kinetic curve shows a rapid enhancement with rapid washout in the highest grades, while a plateau or a persistent enhancement is seen in the lower ones [58][59][60][61][62][63][64]. In addition, high-grade tumors may also present hemorrhage or vascular lakes, displayed as focal areas of hyperintensity on T1-w images [58] (Figure 9).…”

Section: Magnetic Resonance Imagingmentioning

confidence: 98%

Angiosarcoma of the Breast: Overview of Current Data and Multimodal Imaging Findings

Conti

Morciano

Rossati³

et al. 2023

J. Imaging

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Angiosarcoma of the breast is a rare breast cancer, which can arise de novo (primary breast angiosarcoma, PBA) or as a secondary malignancy (secondary breast angiosarcoma, SBA) as a result of a biological insult. In the latter case, it is usually diagnosed in patients with a previous history of radiation therapy following a conserving treatment for breast cancer. Over the years, the advances in early diagnosis and treatment of breast cancer, with increasing use of breast-conserving surgery and radiation therapy (instead of radical mastectomy), brought about an increased incidence of the secondary type. PBA and SBA have different clinical presentations and often represent a diagnostic challenge due to the nonspecific imaging findings. The purpose of this paper is to review and describe the radiological features of breast angiosarcoma, both in conventional and advanced imaging to guide radiologists in the diagnosis and management of this rare tumor.

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“…These radio-induced sarcomas occur 5 to 10 years (median at 6 years) after exposure to 50 Grays of radiation. Bilateral breast angiosarcomas are even rarer, with only a few cases reported in the literature, including one case in a breastfeeding woman [9].…”

Section: Case Presentationmentioning

confidence: 99%

“…Clinically, the typical presentation is the rapid enlargement of a breast nodule, as observed in our patient. Tumor size is often substantial, ranging from 2 to 11 cm, with an average of 5.3 cm [9]. The tumor may also be revealed by the sudden onset of a hematoma.…”

Section: Case Presentationmentioning

confidence: 99%

Bilateral Primary Angiosarcoma of the Breast with Asynchronous Ovarian Metastases: A Case Report

Sarah,

Soumia,

Elbatoul

et al. 2023

WJCRCI

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Breast angiosarcomas are rare mesenchymal tumors of vascular endothelial origin, most commonly associated with radiation, and less frequently primary. They are characterized by a distinct clinical and radiological presentation, frequent local recurrence, and a poor prognosis. We report the case of a young patient who presented with primary angiosarcoma in both breasts, occurring a year apart. Subsequently, she developed bilateral ovarian metastases, treated with surgery and radiotherapy for breast tumors, and underwent palliative chemotherapy for ovarian metastases. Diagnostic challenges were encountered in both radiological and pathological aspects. Through this case, we discuss the clinical, radiological, and pathological features of asynchronous bilateral primary angiosarcoma of the breast with ovarian metastases.

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Bilateral primary angiosarcoma of the breast: a case report

Cited by 5 publications

References 15 publications

Primary Angiosarcoma of the Breast: A 20-Year Single-Institution Experience in China

Primary Angiosarcoma of the Breast: A 20-Year Single-Institution Experience in China

Angiosarcoma of the Breast: Overview of Current Data and Multimodal Imaging Findings

Bilateral Primary Angiosarcoma of the Breast with Asynchronous Ovarian Metastases: A Case Report

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