Bilateral persistent hyperplastic primary vitreous: A rare entity

“Strabismus in children” is not simple – bilateral persistent hyperplasia primary vitreous: a case report

“… 3 Bilateral presentations are rare and are associated with systemic and syndromic associations, such as trisomy, Norrie’s disease, and Warburg’s syndrome. 4 Systemic abnormalities, including cleft lip, cleft palate, polydactyly, and microcephaly, could potentially be associated with chromosomal abnormalities. Although a relationship between genetic abnormalities and PHPV has not been reported, several cases of PHPV have been observed in the same family, suggesting the presence of an autosomal dominant or recessive factor.…”

Bilateral primary hyperplastic persistent vitreous: report of two cases

“…Pollard [ 3 ], in his study of 83 cases of PHPV, reported only two cases (2.4%) that had bilateral PHPV. Bilateral presentations are commonly associated with systemic and syndromic associations such as trisomy 13, 15, or 18, Norrie’s disease and Warburg’s syndrome [ 7 ]. However, no systemic anomalies were present in our patients.…”

Unilateral Leukocoria in an Infant

“…Microphthalmia, leukocoria and cataract are the most common clinical findings. There are three types of PHPV, i.e., anterior, posterior and a combination of the two [ 12 ]. Depending on the severity of the case, complications like glaucoma, retinal detachment, intraocular hemorrhage, uveitis and phthisis bulbi could occur [ 13 ].…”