Bilateral Perinephric Pseudocysts and Polycystic Kidneys in a Ferret

Puerto, David A.; Walker, Larry; Saunders, Helen

doi:10.1111/j.1740-8261.1998.tb01611.x

Cited by 14 publications

(8 citation statements)

References 4 publications

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“…25 Similar to the human form, a mutation on the PKD1 gene causes the majority of adult PKD in cats 13,19 whereas autosomal-dominant PKD in Bull Terriers is likely not associated with a mutation in the canine PKD1 or PKD2 genes. 22,23 Similar alterations are also reported in adult ferrets 6,28 and horses 1,5,29 but the genetic background in these species is unknown.…”

Section: Introductionsupporting

confidence: 56%

Polycystic Kidney Disease in Adult Brazilian Agoutis (Dasyprocta leporina)

2009

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Abstract. During the last 21 years, 7 adult captive Brazilian agoutis (Dasyprocta leporina) from 4 different zoologic gardens were necropsied and histologically examined at the Leibniz Institute for Zoo and Wildlife Research, Berlin, Germany. All animals had polycystic kidney disease as the major pathologic change. Except in 1 case, no clinical signs were recognized prior to death. The animals had macroscopic bilateral alterations of the kidneys ranging from granulated surfaces to severe polycystic changes. Microscopic examination revealed multifocal to generalized, moderate to severe cystic dilatations of Bowman's capsules and renal tubules, moderate mesangial and capsular proliferation of the renal corpuscles, mild interstitial fibrosis, and mild to moderate interstitial lympho-plasmacytic infiltrations. Little information is known about the genetic relationships of these animals, but breeding practice indicates a high possibility of inbred agouti zoo populations in Germany. This is the first report on polycystic kidney disease in Brazilian agoutis with possible genetic background.

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Section: Introductionsupporting

confidence: 56%

Polycystic Kidney Disease in Adult Brazilian Agoutis (Dasyprocta leporina)

2009

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“…6, 8, 9 Perinephric pseudocysts are uncommon lesions in cats and are rare in dogs, ferrets, pigs, and humans. 4, 7, 11–13 This manuscript characterizes a unilateral perinephric pseudocyst secondary to hydronephrosis in a C57BL/6J mouse.…”

mentioning

confidence: 99%

“…6,8,9 Perinephric pseudocysts are uncommon lesions in cats and are rare in dogs, ferrets, pigs, and humans. 4,7,[11][12][13] This manuscript characterizes a unilateral perinephric pseudocyst secondary to hydronephrosis in a C57BL/6J mouse.A 9-month-old female C57BL/6J mouse, part of a control group of an impending research study, showed progressive abdominal distension over 1 week's time. The mouse was euthanatized with carbon dioxide, and an incision of the abdomen showed a distended left kidney.…”

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confidence: 99%

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Unilateral Perinephric Pseudocyst Secondary to Hydronephrosis in a C57BL/6J Mouse

Meyerholz¹,

Hostetter²

2005

Vet Pathol

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Abstract. A 9-month-old C57BL/6J mouse had progressive abdominal distension over a 1-week period, and a distended left renal capsule was discovered at postmortem examination. Incision of the capsule showed a tan, cloudy fluid that separated the renal capsule and the remnant left kidney. Microscopically, the capsule was significantly separated from the renal parenchyma by clear space and necrotic cellular debris. The majority of the lining of the renal capsule was composed of fibrous connective tissue and lacked an epithelial lining, consistent with a subcapsular perinephric pseudocyst. In addition, attached to intermittent portions of the renal capsule were thin rims of compressed cortical tissue lined by transitional epithelium. The finding of remnant cortical tissue lined by transitional epithelium is consistent with severe hydronephrosis and indicates that the hydronephrosis preceded the formation of the perinephric pseudocyst. To our knowledge, this is the first case report to characterize a perinephric pseudocyst secondary to severe hydronephrosis in a mouse.Key words: C57BL/6J mice; hydronephrosis; perinephric pseudocyst; perirenal pseudocyst.Perinephric pseudocysts are locally extensive accumulations of fluid in a fibrous sac surrounding one or both kidneys. 8 The fluid accumulation may be extracapsular, but it is often subcapsular between the fibrous renal capsule and renal parenchyma. 1 Whereas a cyst is defined as a fluid filled cavity lined by epithelium, the term pseudocyst is more appropriate for this lesion, as it lacks an epithelial lining. 9 A review of the literature indicates multiple synonyms for this lesion, including capsulogenic renal cyst, capsular cyst, pararenal cyst, pararenal pseudocyst, capsular hydronephrosis, perirenal cyst, perirenal pseudocyst, and pseudohydronephrosis. 6,8,9 Perinephric pseudocysts are uncommon lesions in cats and are rare in dogs, ferrets, pigs, and humans. 4,7,[11][12][13] This manuscript characterizes a unilateral perinephric pseudocyst secondary to hydronephrosis in a C57BL/6J mouse.A 9-month-old female C57BL/6J mouse, part of a control group of an impending research study, showed progressive abdominal distension over 1 week's time. The mouse was euthanatized with carbon dioxide, and an incision of the abdomen showed a distended left kidney. The entire body was placed in 10% neutral-buffered formalin and submitted to Iowa State University's Surgical Pathology Service for histopathologic diagnosis. On examination, the renal capsule was greatly distended (3.4 ϫ 2.5 ϫ 2.2 cm) ( Fig. 1) and encased a tan, turbid fluid. Cytospin preparations were nondiagnostic due to formalin fixation. Near the hilus of the capsule was an aggregate of tissue compatible with the remnant kidney, and the adjacent proximal ureter had small, pale serosal nodules (ϳ1 mm).The tissues were processed routinely and stained with hematoxylin and eosin (HE) for microscopic evaluation. The remnant left kidney was slightly shrunken (8 ϫ 5 ϫ 4 mm), and the capsule was elevated above the parenchym...

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“…Die Disposition des Frettchens zur Ausbildung multipler Nierenzysten ist aus Sektionsstatistiken bekannt (3). Ihr sonographischer Nachweis wurde bisher allerdings erst in einem Fall beschrieben (26). Nach einer neueren Untersuchung geht man bisher davon aus, dass ca.…”

Section: /184unclassified

Die abdominale Ultraschalluntersuchung beim Frettchen (Mustela putorius f. furo L. 1758)

Reese¹,

Frings²

2004

Tierarztl Prax Ausg K

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Zusammenfassung: Gegenstand und Ziel: Ziel dieser Studie war, einen Überblick über die sonographische Anatomie der Bauchhöhlenorgane beim Frettchen zu geben und die häufigsten pathologischen Befunde darzustellen. Material und Methoden: Bei 26 klinisch gesunden und 17 mit unterschiedlichen Krankheitssymptomen wie Apathie, Alopezie, Diarrhö und Dauerranz zur Untersuchung vorgestellten Frettchen wurde eine Ultraschalluntersuchung des Abdomens durchgeführt. Sie erfolgte am unsedierten, manuell in Rückenlage fixierten Frettchen mit einem 12-MHz-Linearschallkopf. Ergebnisse: Mit Ausnahme des Pankreas ließen sich alle Organe der Bauchhöhle darstellen. Als anatomische Eigenheit der Frettchen ist der mit einem physiologischen Durchmesser zwischen 7 und 15 mm auffällig große kraniale Mesenteriallymphknoten zu beachten. Er ist sonographisch leicht an seinem charakteristisch eingezogenen Hilus sowie der deutlichen Differenzierung von Mark und Rinde zu erkennen und darf nicht mit einem Tumor verwechselt werden. Die häufigsten sonographisch gestellten Befunde waren multiple Nierenzysten (27 Tiere), eine Hyperechogenität des Nierenmarks (23 Tiere), Splenomegalie (15 Tiere), Aszites (sieben Tiere), Nebennierentumoren (sechs Tiere) und Lymphadenopathien (fünf Tiere). Bei einer Fähe mit Symptomen eines Hyperöstrogenismus konnten zystisch entartete Eierstöcke nachgewiesen werden. Schlussfolgerung: Insgesamt betrachtet erwies sich die abdominale Sonographie beim Heimtier Frettchen als gut durchführbare und aussagekräftige Untersuchungsmethode. Klinische Relevanz: Der abdominalen Ultraschalluntersuchung sollte in der klinischen Diagnostik beim Frettchen der gleiche Stellenwert wie bei Hund und Katze zukommen.

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Bilateral Perinephric Pseudocysts and Polycystic Kidneys in a Ferret

Cited by 14 publications

References 4 publications

Polycystic Kidney Disease in Adult Brazilian Agoutis (Dasyprocta leporina)

Polycystic Kidney Disease in Adult Brazilian Agoutis (Dasyprocta leporina)

Unilateral Perinephric Pseudocyst Secondary to Hydronephrosis in a C57BL/6J Mouse

Die abdominale Ultraschalluntersuchung beim Frettchen (Mustela putorius f. furo L. 1758)

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