Bilateral pedal edema associated with olanzapine use in manic episode of bipolar disorder: Report of two cases

Peripheral Edema Occurring during Treatment with Risperidone Combined with Citalopram

“…First, the action of risperidone on the α -receptors of the peripheral vascular system may have caused vasodilation and raised the hydrostatic pressure in the blood capillaries, which would result in edema [18]. Second, risperidone-induced 5-HT2 receptor blockade can potentially increase the levels of cyclic adenosine monophosphate, which relaxes vascular smooth muscle through the phosphorylation of myosin light chain kinase [19].…”

Olanzapine‐induced limb edema simulating episodic angioedema with eosinophilia

“…Limb edema induced by quetiapine, 4 another atypical antipsychotic with similar pharmacological activity, can support the hypothesis. Although the constant administration of quetiapine was not directly correlated with the periodic limb edema of this case, quetiapine might additively work with OLZ on the clinical manifestation because OLZ‐induced limb edema possibly shows dose‐dependency 3 . In our case, non‐pitting edema on the patient’s lower legs was recurrently observed with increased bodyweight accompanied by moderate eosinophilia and liver dysfunction.…”

“…The pathomechanism of the OLZ‐induced edema is thought to depend on the unique pharmacological effect of so‐called multi‐acting receptor‐targeted antipsychotic drugs. The vasodilation via blockade of multiple receptors, such as α‐adrenergic, muscarine 1, histamine 1 and 5‐HT 2 receptors, directly or indirectly causes the edema 3 . Limb edema induced by quetiapine, 4 another atypical antipsychotic with similar pharmacological activity, can support the hypothesis.…”

Bilateral pedal edema in an HIV patient: Lopinavir/Ritonavir-containing treatment regimen as a potential cause?

“…Psychiatric drugs reported to cause bilateral pedal edema include Olanzepine [9][10][11] and Lithium [12]. Acitretin, a retinoid used in psoriasis, has also been shown to cause bilateral pedal edema [13].…”