Bilateral orchiectomy versus total androgen blockade in the management of metastatic cancer prostate

Rajesh, Rajesh; Nigam, Divya

doi:10.18203/2349-2902.isj20160667

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…ADT is mainly dependent on suppression of androgens of testicular origin [5] . ADT is performed via two ways: surgical ablation of testes or medical androgen blockade via synthetic analogs of gonadotropin-releasing hormone [6] . Regardless of the causes or ways, ADT raises the risk of oxidative stress that could cause brain damage, diabetes mellitus (DM ) and heart disease [7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Follow up of the pancreatic structural alterations in a rat model of andropause induced by bilateral orchiectomy after different time periods

Gouda¹,

El-naseery

Khalifa³

2018

Egyptian Journal of Histology

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Introduction:The pancreas and male gonads shared similar utilities. Aim: To follow-up the pancreatic structural alterations after orchiectomy on different times. Materials and Methods: Twenty-four rats were allocated into sham-operated (Group I, n=6) and orchiectomized (Orx) (Group II, n=18). After 2 weeks of rest, the Gr II was equally re-distributed into subgroups IIa, IIb, and IIc depending on sacrifice time (3, 6 and 9 weeks, respectively). The pancreatic specimens were processed and stained with H&E and were immunostained with anti-insulin and glucagon proteins and anti-single-strand DNA (ss-DNA). Body masses, serum testosterone, fasting plasma glucose levels, oxidant and antioxidant markers were measured. The optical density of insulin immunopositive reaction and immunopositive area % of insulin, glucagon, and ss-DNA were realized with image analyzer. Data were statistically analyzed by ANOVA's and Tukey's test.Results: This study revealed that the orchiectomized rats were hyperglycemic. The oxidative stress was significantly elevated while the antioxidant enzyme was significantly decreased. Structurally, in Gr IIa, the acini were deformed and shrunken. The acinar cells had less basophilic cytoplasm with small and darkly basophilic nuclei, while the islets cells appeared deeply acidophilic with small darkly stained nuclei. The apoptotic cells were observed in some acinar cells and in cells peripherally located in islets. The positive area% of the β cell was non-significantly decreased, whereas the positive area% of α cell was significantly decreased. Additionally, the positive area% of apoptotic cells was significantly increased. Gr IIb and GrIIc revealed the same structural changes as in GrIIa. Conclusion: Orchiectomy-induced testosterone deficiency affects the exocrine and endocrine pancreatic portions, both with a risk for pancreatogenic diabetes (type III). Therefore, we should be more cautious before performing orchiectomy in humans or animals.

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Section: Introductionmentioning

confidence: 99%

Follow up of the pancreatic structural alterations in a rat model of andropause induced by bilateral orchiectomy after different time periods

Gouda¹,

El-naseery

Khalifa³

2018

Egyptian Journal of Histology

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Expert Group Consensus Opinion on Prostate Cancer Diagnosis and Management in India: Part 2 of 2

Ghose

Khochikar

Sabnis

et al. 2021

Korean J Urol Oncol

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With limited/no guidelines on prostate cancer (PCa) diagnosis and management currently in India, this consensus statement has been developed to evaluate Indian literature and current clinical practices to assist healthcare professionals across India in the diagnosis and management of patients with PCa. A group of leading PCa experts from across India convened at the 2019 CAP summit in Kolkata, India, to vote on 42 consensus statements on PCa diagnosis and management. In the subsequent meeting, an expert panel discussed on the consensus results. On the basis of the voting results and the subsequent expert panel discussion, 5 of 42 statements were deleted and 37 were accepted and retained in the final draft, which is divided into 2 parts. This paper covers part 2, which describes in detail the remaining 21 of 37 statements on locally advanced PCa and metastatic PCa with varying degrees of support from the panel. The consensus statement extrapolated from Indian scientific evidences, regional clinical experiences, and international guidelines will serve as a reference guide for clinicians across India in the diagnosis and management of PCa.

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Bilateral orchiectomy versus total androgen blockade in the management of metastatic cancer prostate

Cited by 2 publications

References 7 publications

Follow up of the pancreatic structural alterations in a rat model of andropause induced by bilateral orchiectomy after different time periods

Follow up of the pancreatic structural alterations in a rat model of andropause induced by bilateral orchiectomy after different time periods

Expert Group Consensus Opinion on Prostate Cancer Diagnosis and Management in India: Part 2 of 2

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