Bilateral Neuroretinitis Associated With Mumps

Khubchandani, Raju; Rane, Tej; Agarwal, Premlata; Nabi, Fazul; Patel, Phiroze; Shetty, Avinash K.

doi:10.1001/archneur.59.10.1633

Cited by 27 publications

(6 citation statements)

References 17 publications

(12 reference statements)

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“…To the best of our knowledge, this is the first report of bilateral optic neuritis secondary to mumps meningoencephalitis in Pakistan. There have been similar pediatric ON reports from other regions, including India (seven-year-old girl), Japan (five-year-old boy), and the United States (seven-year-old girl) [11][12][13].…”

Section: Discussionsupporting

confidence: 57%

Bilateral Optic Neuritis: A Rare Complication of Mumps

Khan¹,

Nasir²,

Hanif³

2020

Cureus

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Mumps is a contagious viral illness that classically presents with fever, parotid gland swelling, headache, and vomiting in unimmunized children. The complications of mumps most commonly include orchitis, pancreatitis, encephalitis, and meningitis. Optic neuritis, which refers to the inflammation of the optic nerve, in rare cases, can present after mumps meningoencephalitis and causes pain in the eye, and a decrease in visual acuity. We report and discuss a case of bilateral optic neuritis following mumps meningoencephalitis in a child. The patient was managed with short-term steroid therapy.

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Section: Discussionsupporting

confidence: 57%

Bilateral Optic Neuritis: A Rare Complication of Mumps

Khan¹,

Nasir²,

Hanif³

2020

Cureus

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“…Other central nervous system complications include acute and chronic encephalitis, transverse myelitis, hydrocephalus and acute cerebellar ataxia [27]. Transverse myelitis [29,30] and optic neuritis [31], both symptoms of NMO, have been reported subsequent to mumps infection or mumps virus vaccination. Some reports have suggested an association of optic neuritis [22,32] with mumps virus.…”

Section: Discussionmentioning

confidence: 99%

Detection of mumps virus RNA in cerebrospinal fluid of patients with neuromyelitis optica

et al. 2011

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Neuromyelitis optica (NMO) is an acute inflammatory disease that preferentially involves the optic nerves and spinal cord. Although many infectious agents, including mumps virus, are postulated to have a role in the pathogenesis of multiple sclerosis (MS), the relationship between NMO and infectious agents remains uncertain. To investigate the relationship between NMO and viruses that have special affinity for the central nervous system, we performed a nested polymerase chain reaction (PCR) to detect mumps virus or enterovirus RNA in cerebrospinal fluid samples from 13 patients with MS, 8 with NMO and 20 with other neurological diseases (ONDs). Nested PCR was positive for mumps virus in 2 (25%) of NMO patients, but in none of those with MS and ONDs. Moreover, nested PCR results became negative in the remission phase in the two PCR-positive NMO patients. Mumps virus may have some role in the pathogenesis of NMO.

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“…In acute demyelinating optic neuritis, intravenous methylprednisolone can hasten recovery of visual function but does not affect long-term visual outcome [2,15]. Postinfectious optic neuritis often shows good prognosis without treatment [3]. However, because our patient showed persistent disabling visual symptoms 3 weeks after onset, we treated the patient with corticosteroids and hastened [4,10,11].…”

Section: Takashi Irioka Miho Akaza Keisuke Nakao Tadashi Kanouchi Takmentioning

confidence: 88%

“…Optic neuritis (usually bilateral) and neuroretinitis are rare neurological complications following mumps infection [1,3,4]. Chiasmal optic neuritis, a rare disorder involving the optic chiasma, occurs in autoimmune demyelinating disorders, and may be the initial manifestation of MS [5,6].…”

Section: Takashi Irioka Miho Akaza Keisuke Nakao Tadashi Kanouchi Takmentioning

confidence: 99%