Bilateral neuro-retinitis following chick embryo cell anti-rabies vaccination – a case report

Abstract

BackgroundThe Optic nerve is rarely involved after sheep brain anti-rabies vaccination in the form of retrobulbar neuritis or papillitis. Bilateral neuroretinitis after chick embryo cell antirabies vaccination has not been reported.Case presentationWe report the case of a 56 year old male who developed bilateral neuro-retinitis following three injections of antirabies vaccine prepared from the chick embryo.ConclusionThe chick embryo cell antirabies vaccine can cause bilateral neuroretinits which has not been reported previously.

Optic neuritis following anti-rabies vaccine

“…However, incomplete visual recovery may result because of permanent macular damage. 10 In our case, anti-rabies vaccine derived from chicken embryo cells is usually not associated with any neuroparalytic complications, though one case each, of neuroretinitis 11 and Guillain-Barre syndrome, 12 have been reported. The manufacturer's information also does not mention the risk of neurological complications.…”

Neuroretinitis after the second injection of a SARS-CoV-2-vaccine: A case report

“… 24 Although the exact mechanism is unknown, vaccine-induced optic neuritis is believed to occur because the T-cells activated by vaccines cross the blood-brain barrier, resulting in type IV hypersensitivity. 25 , 26 Neuroretinitis, an inflammatory disorder of the optic nerve head associated with exudates or edema around the macula, 7 , 8 was associated with anti-rabies vaccination in the case report 9 ; of a patient who developed acute, painless visual loss 1 day after the third injection and 5 days after the second injection of a chick embryo cell anti-rabies vaccine (i.e., injection days 0, 3, and 7 after a dog bite). 9 The patient showed optic disc swelling and macular exudates in both eyes.…”

“… 25 , 26 Neuroretinitis, an inflammatory disorder of the optic nerve head associated with exudates or edema around the macula, 7 , 8 was associated with anti-rabies vaccination in the case report 9 ; of a patient who developed acute, painless visual loss 1 day after the third injection and 5 days after the second injection of a chick embryo cell anti-rabies vaccine (i.e., injection days 0, 3, and 7 after a dog bite). 9 The patient showed optic disc swelling and macular exudates in both eyes. 9 Our case did not show typical macular star or subretinal fluid affecting the foveal center, and MRI revealed inflammation extending to the retrobulbar area; however, certain findings, including predominant optic nerve head inflammation and exudates and swelling from the disc distributed toward the macular area were considered to be compatible with neuroretinitis.…”

“… 9 The patient showed optic disc swelling and macular exudates in both eyes. 9 Our case did not show typical macular star or subretinal fluid affecting the foveal center, and MRI revealed inflammation extending to the retrobulbar area; however, certain findings, including predominant optic nerve head inflammation and exudates and swelling from the disc distributed toward the macular area were considered to be compatible with neuroretinitis.…”

“…Neuroretinitis is an inflammatory disorder of the eye presenting with optic disc swelling with marked peripapillary and macular exudates. 7 , 8 Only a single case report describing a temporal association between chick embryo cell anti-rabies vaccination and neuroretinitis has been published, 9 and no other reports of neuroretinitis following COVID-19 vaccination have been released. Herein, we report a case of neuroretinitis after administration of a second dose of the Comirnaty® COVID-19 vaccine.…”