Bilateral multiple sclerosing hemangiomas of the lung

Maeda, Ryo; Isowa, Noritaka; Miura, Hiroshi; Tokuyasu, Hirokazu; Kawasaki, Yuki; Yamamoto, Kazumichi

doi:10.1007/s11748-009-0452-y

Cited by 29 publications

(25 citation statements)

References 9 publications

(13 reference statements)

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“…Only one patient had multiple bilateral lesions that showed stability on follow-up, even after 4 years, concordant with outcomes described in previous case reports, suggesting that multiplicity does not necessarily imply biological aggressiveness. [6][7][8] One patient was found to have nodal metastasis, in line with the 2%-4% rate previously reported. 9 We would still classify this as a benign tumor because recurrence is reported to be very rare, even amongst those with lymph node involvement, and no mortality has been reported in the literature.…”

Section: Discussionsupporting

confidence: 86%

Pulmonary sclerosing hemangioma: pitfalls in management

Low

Teo

Eng

et al. 2011

Asian Cardiovasc Thorac Ann

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Pulmonary sclerosing hemangioma is a rare benign tumor for which surgical excision is curative with an excellent prognosis. It often mimics malignancy, making it a diagnostic and management challenge. We reviewed the clinical, radiological, and histopathological characteristics as well as the surgical management of our patients to assess the potential pitfalls in management. All 19 patients who underwent surgical biopsy between January 1999 and December 2009 with a final histopathological diagnosis of pulmonary sclerosing hemangioma were reviewed retrospectively. The median age was 48 years, 89.5% were female, 89.5% were Chinese, and 68.4% were asymptomatic. There were no specific diagnostic radiological characteristics; 1 of 3 patients who underwent combined positron-emission and computed tomography had a false-positive result. Preoperative attempts at establishing a diagnosis were successful in 20% of patients who had invasive procedures. Intraoperative frozen-section evaluation for pulmonary sclerosing hemangioma had an error rate of 25% and a deferred rate of 31%, resulting in nearly half of our patients undergoing unnecessary extensive surgical procedures. We hope to heighten awareness of this diagnosis, thereby increasing the index of suspicion and minimizing errors in diagnosis.

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Section: Discussionsupporting

confidence: 86%

Pulmonary sclerosing hemangioma: pitfalls in management

Low

Teo

Eng

et al. 2011

Asian Cardiovasc Thorac Ann

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“…In addition, PSH may be low-grade malignancy, since cases of lymph node and lung metastases have been reported. Thus, FDG PET/CT could be useful for the differential diagnosis of low-grade malignancy of PSH, particularly when the SUVmax of PSH exceeds 2.5, or when lymph node and lung metastases are displayed on PET/CT images (9)(10)(11)(12)(13)(14), which would be of great assistance in the clinical treatment.…”

Section: Discussionmentioning

confidence: 99%

“…However, a few studies have suggested that certain benign pulmonary tumors, such as PSH, may be low-grade malignancies, since cases of lymph node and lung metastases have been reported (9)(10)(11)(12)(13)(14), or that the malignant transformation of lung benign tumors may be possible, such as the transformation of pulmonary hamartoma into adenocarcinoma, sarcoma or squamous cell carcinoma (15)(16)(17). Thus, it is also important to compare and analyze the characteristics of 18 F-FDG PET/CT in benign lung tumors and to evaluate their metabolic activities to choose the proper clinical management.…”

Section: Introductionmentioning

confidence: 99%

18F‑FDG PET/CT characteristics of pulmonary sclerosing hemangioma vs. pulmonary hamartoma

et al. 2018

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Abstract. The radiological features of pulmonary sclerosing hemangioma (PSH) and pulmonary hamartoma are poorly specified. Thus, the present study aimed to compare and analyze the characteristics of fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) in PSH versus pulmonary hamartoma.18 F-FDG PET/CT characteristic findings of 12 patients with PSH and 14 patients with pulmonary hamartoma were retrospectively reviewed. A total of 12 lesions were detected from the 12 patients with PSH, of which 3 masses exhibited calcification. The mean diameter and standardized maximum uptake value (SUVmax) were 1.9±0.7 cm and 2.6±1.0, respectively, and there was no significant correlation between the lesion size and SUVmax (P>0.05). For the 14 patients with pulmonary hamartoma, 14 lesions were found, of which 4 exhibited calcification. The mean diameter and SUVmax were 1.7±0.8 cm and 1.5±0.6, respectively, and there was a significant correlation between the size and SUVmax (r= 0.625, r 2 = 0.391, P<0.05). Although there was no significant difference between the size of PSH and pulmonary hamartoma (P>0.05), the SUVmax of PSH was significantly higher than that of pulmonary hamartoma (P<0.05). Moreover, the SUVmax of 1.95 was applied as a cutoff for the diagnosis of PSH, and the resulting sensitivity and specificity for PET/CT to differentiate PSH from pulmonary hamartoma were 83.3 and 78.6%, respectively. Although the morphological features were not specific, PSH showed significantly higher FDG accumulation than pulmonary hamartoma on PET/CT imaging, which may aid the differential diagnosis. Further studies with larger populations are warranted to confirm these study results.

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“…Rare cases of multiple or bilateral PSHs have been reported [3,13] whereas the tumor can be endobronchial, pleural or mediastinal [2,7]. A slight predilection for the right lung has been reported [19].…”

Section: Discussionmentioning

confidence: 99%

Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: Management and review of the literature

Salemis

Seretis

Νάκος

et al. 2013

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Pulmonary sclerosing hemangioma (PSH) is a rare tumor accounting for 0.2-1% of all primary lung tumors. Simultaneous occurrence of PSH with breast cancer has very rarely been reported in the literature. We describe here a case of simultaneous occurrence of PSH with breast cancer. A pathological diagnosis of PSH was confirmed by computed tomography (CT)-guided biopsy. Due to the patient's poor performance status and the benign nature of PSH, surgical excision was not considered and the patient was managed conservatively with regular follow-up. Although surgical excision is the preferred treatment for PSH, conservative management may be a reasonable option in carefully selected patients.

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Bilateral multiple sclerosing hemangiomas of the lung

Cited by 29 publications

References 9 publications

Pulmonary sclerosing hemangioma: pitfalls in management

Pulmonary sclerosing hemangioma: pitfalls in management

18F‑FDG PET/CT characteristics of pulmonary sclerosing hemangioma vs. pulmonary hamartoma

Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: Management and review of the literature

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