Bilateral multiple malignant transformation of Ollier’s disease

Abstract

We treated a 26-year-old man with a 19-year history of Ollier's disease. Secondary chondrosarcomas developed metachronously at four separate locations: both femora, left proximal tibia and fibular head. All four lesions were surgically excised, and each specimen was histologically identified as grade 1 or 2 chondrosarcoma. Clinical follow-up for 20 years beginning at the time of first tumor surgery has shown no evidence of local recurrence or metastasis. This is the first report of multiple bilateral metachronous malignant transformation of multiple chondromatoses in a patient with Ollier's disease.

Malformation of the humerus in a patient with Ollier disease treated with the Ilizarov technique

“…6,9 We report a sixth case of humeral malformation due to Ollier disease in a 37-year-old woman. Lengthening of the humerus and progressive realignment were performed using the Ilizarov technique, resulting in cosmetic and functional improvement after length was restored and the angular deformity was reduced.…”

Eponyms of Tumors and Tumorlike Lesions in the Musculoskeletal System: Who Were the People and What Are the Lesions? Pictorial Review

“…Bone scanning may aid in the detection of multiple enchondromas in the entire skeleton. CT and MRI are helpful to evaluate complications such as fractures and sarcomatous transformation of enchondromas [42].…”

“…Clinical problems include skeletal deformities and limb-length discrepancy. In particular, malignant transformation into chondrosarcoma is a well-known complication and the rate of occurrence varies, ranging between 5% and 50%, in the literature [41,42].…”

Bone Tumors of the Hands: Focus on CT and MR Findings

“…Chondrosarcoma is the most common malignant bone tumor in the hand and about 1% of chondrosarcomas involve the hands [51]. Chondrosarcomas in the hands are common in the 6 th to 8 th decade of life [52], whereas the secondary chondrosarcomas of Ollier's disease occur at a younger age (around 3 rd to 4 th decade) [5]. The common site for the chondrosarcoma in the hand is the proximal phalanx.…”